Wu Tsai Human Performance Alliance
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Haopeng Xiao
Assistant Professor of Biochemistry
BioUnderstanding mechanisms of metabolic regulation in physiology and disease forms the basis for developing therapies to treat diseases in which metabolism is perturbed. We devise novel mass spectrometry (MS)-based proteomics technologies, combined with data science, to systematically discover mechanisms of metabolic regulation over protein function. Our strategies established the first tissue-specific landscape of protein cysteine redox regulation during aging, elucidating mechanisms of redox signaling in physiology that remained elusive for decades. We also leverage the genetic diversity of outbred populations to systematically annotate protein function and protein-metabolite co-regulation. The aim of our research program is to develop next-generation MS-based strategies to understand mechanisms of metabolic regulation in aging, metabolic disease, and cancer, and to use this knowledge as a basis to develop translational therapeutics.
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Sheng Xu
Professor of Anesthesiology, Perioperative & Pain Medicine (Department Research) and, by courtesy, of Electrical Engineering
BioDr. Sheng Xu is a tenured professor and the inaugural Director of Emerging Technologies in the Department of Anesthesiology, Perioperative and Pain Medicine at Stanford University, with a courtesy appointment in Electrical Engineering. He earned his B.S. degree in Chemistry from Peking University and his Ph.D. in Materials Science and Engineering from the Georgia Institute of Technology. Subsequently, he pursued postdoctoral studies at the Materials Research Laboratory at the University of Illinois at Urbana-Champaign. He then spent 10 years on the faculty at UC San Diego before joining Stanford in 2025. His research group is interested in developing new materials and fabrication methods for soft electronics. His research has been presented to the United States Congress as a testimony to the importance and impact of NIH funding.