Wu Tsai Neurosciences Institute
Showing 141-150 of 645 Results
-
Shaul Druckmann
Associate Professor of Neurobiology, of Psychiatry and Behavioral Sciences and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsOur research goal is to understand how dynamics in neuronal circuits relate and constrain the representation of information and computations upon it. We adopt three synergistic strategies: First, we analyze neural circuit population recordings to better understand the relation between neural dynamics and behavior, Second, we theoretically explore the types of dynamics that could be associated with particular network computations. Third, we analyze the structural properties of neural circuits.
-
Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioResearch and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
In a second program area, the Du Bois group is exploring voltage-gated ion channel structure and function using the tools of chemistry in combination with those of molecular biology, electrophysiology, microscopy and mass spectrometry. Much of this work has focused on studies of eukaryotic Na and Cl ion channels. The Du Bois lab is interested in understanding the biochemical mechanisms that underlie channel subtype regulation and how such processes may be altered following nerve injury. Small molecule toxins serve as lead compounds for the design of isoform-selective channel modulators, affinity reagents, and fluorescence imaging probes. Access to toxins and modified forms thereof (including saxitoxin, gonyautoxin, batrachotoxin, and veratridine) through de novo synthesis drives studies to elucidate toxin-receptor interactions and to develop new pharmacologic tools to study ion channel function in primary cells and murine pain models. -
Alfredo Dubra, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsOur lab seeks to help the early diagnosing and monitoring progression of ocular, vascular, neurodegenerative and systemic diseases through novel non-invasive optical ophthalmic imaging. We pursue this goal through a multidisciplinary approach that integrates optics, computer science, vision science, electrical engineering and other engineering disciplines.
-
Laramie Duncan
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly InterestsOur work is at the intersection of statistical genetics, psychiatry, and neuroscience. We use massive datasets and primarily computational approaches to identify mechanisms contributing to mental health problems like schizophrenia and depression. The overall goal of the lab is to discover fundamental information about psychiatric disorders, and ultimately to build more effective approaches to classification, prevention, and treatment.
-
Alexander Dunn
Professor of Chemical Engineering
Current Research and Scholarly InterestsMy lab is deeply interested in uncovering the physical principles that underlie the construction of complex, multicellular animal life.
-
James Dunn
Professor of Surgery (Pediatric Surgery)
Current Research and Scholarly InterestsIntestinal lengthening for short bowel syndrome
Intestinal stem cell therapy for intestinal failure
Skin derived precursor cell therapy for enteric neuromuscular dysfunction
Intestinal tissue engineering -
Jeffrey Dunn, MD
Clinical Professor, Adult Neurology
Current Research and Scholarly InterestsTranslational research in the human application of emerging immunotherapies for neurological disease, focusing on Multiple Sclerosis, CIS, transverse myelitis and Neuromyelitis Optica (NMO). Collaborative research with Stanford and extramural scientific faculty to identify biomarkers of disease activity and treatment response in humans. Clinical trials to assess efficacy of emerging treatments for MS, CIS and NMO.
-
Gozde Durmus
Assistant Professor (Research) of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsDr. Durmus' research focuses on applying micro/nano-technologies to investigate cellular heterogeneity for single-cell analysis and personalized medicine. At Stanford, she is developing platform technologies for sorting and monitoring cells at the single-cell resolution. This magnetic levitation-based technology is used for wide range of applications in medicine, such as, label-free detection of circulating tumor cells (CTCs) from blood; high-throughput drug screening; and rapid detection and monitoring of antibiotic resistance in real-time. During her PhD, she has engineered nanoparticles and nanostructured surfaces to decrease antibiotic-resistant infections.
-
Shirit Einav
Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsOur basic research program focuses on understanding the roles of virus-host interactions in viral infection and disease pathogenesis. This program is combined with translational efforts to apply this knowledge for the development of broad-spectrum host-centered antiviral approaches to combat emerging viral infections, including dengue, encephalitic alphaviruses, coronaviruses, and filoviruses, and means to predict disease progression.
-
Abbas El Gamal
Hitachi America Professor in the School of Engineering and Senior Fellow at the Precourt Institute for Energy
BioAbbas El Gamal is the Hitachi America Professor in the School of Engineering and Professor in the Department of Electrical Engineering at Stanford University. He received his B.Sc. Honors degree from Cairo University in 1972, and his M.S. in Statistics and Ph.D. in Electrical Engineering both from Stanford University in 1977 and 1978, respectively. From 1978 to 1980, he was an Assistant Professor of Electrical Engineering at USC. From 2003 to 2012, he was the Director of the Information Systems Laboratory at Stanford University. From 2012 to 2017 he was Chair of the Department of Electrical Engineering at Stanford University. His research contributions have been in network information theory, FPGAs, and digital imaging devices and systems. He has authored or coauthored over 230 papers and holds 35 patents in these areas. He is coauthor of the book Network Information Theory (Cambridge Press 2011). He has received several honors and awards for his research contributions, including the 2016 Richard W. Hamming Medal, the 2012 Claude E. Shannon Award, and the 2004 INFOCOM Paper Award. He is a member of the U.S. National Academy of Engineering and a Fellow of the IEEE. He has co-founded and served on the board of directors and advisory boards of several semiconductor and biotechnology startup companies.
