Wu Tsai Neurosciences Institute
Showing 21-30 of 46 Results
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E.J. Chichilnisky
John R. Adler Professor, Professor of Neurosurgery and of Ophthalmology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsFunctional circuitry of the retina and design of retinal prostheses
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Yueh-hsiu Chien
Professor of Microbiology & Immunology
Current Research and Scholarly InterestsContribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.
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Wah Chiu
Wallenberg-Bienenstock Professor and Professor of Bioengineering and, by courtesy, of Microbiology and Immunology
Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
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Eun Young Choi, PhD
Instructor, Neurosurgery
Current Research and Scholarly InterestsDr. Choi is broadly interested in mapping the brain’s connectivity and characterizing its functional dynamics using advanced neuroimaging and clinical neurophysiological methods, as well as translating this information to identify individual-specific neurosurgical targets and treatment strategies using neuromodulation (e.g., deep brain stimulation). Her prior work has mapped the functional and connectional organization of the cortex, striatum, and thalamus using neuroimaging and NHP neuroanatomical tract-tracing. She is currently focused on the use of thalamic deep brain stimulation to improve memory and attention in traumatic brain injury and Alzheimer’s disease, and the development of precise, individual-specific adult and pediatric brain atlases and network maps.
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Danny Hung-Chieh Chou
Associate Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
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Steven Chu
William R. Kenan Jr. Professor, Professor of Molecular and Cellular Physiology and of Energy Science and Engineering
Current Research and Scholarly InterestsSynthesis, functionalization and applications of nanoparticle bioprobes for molecular cellular in vivo imaging in biology and biomedicine. Linear and nonlinear difference frequency mixing ultrasound imaging. Lithium metal-sulfur batteries, new approaches to electrochemical splitting of water. CO2 reduction, lithium extraction from salt water
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Thomas Clandinin
Shooter Family Professor
Current Research and Scholarly InterestsThe Clandinin lab focuses on understanding how neuronal circuits assemble and function to perform specific computations and guide behavior. Taking advantage of a rich armamentarium of genetic tools available in the fruit fly, combined with imaging, physiology and analytical techniques drawn from systems neuroscience, we examine a variety of visual circuits.
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David Clark
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)
BioMy career is dedicated to improving the safety, effectiveness and availability of pain relief. Both the needs and opportunities in these areas are limitless. I have had the good fortune of working as a clinician, teacher and scientist at Stanford University and the Palo Alto VA hospital for more than two decades.
Much of my time is spent on laboratory, translational and clinical research. In the laboratory, we are pursuing several projects related to the questions of why pain sometimes becomes chronic after injuries and why opioids lose their effectiveness over time. Alterations in endogenous pain control mechanisms and the involvement of the adaptive system of immunity are central to these investigations. We would like to find ways to maximize functional recovery after surgery and other forms of trauma while minimizing the risks of analgesic use. This work involves local, national and international collaborations. Clinical trials work involves establishing the efficacy of novel forms of analgesic therapy as well as the comparative effectiveness of long-established approaches to controlling common forms of pain such as low back pain. This spectrum of pain-related pursuits continues to evolve with the rapid expansion of the field. -
Eve Clark
Richard Lyman Professor in the Humanities, Emerita
BioI am interested in first language acquisition, the acquisition of meaning, acquisitional principles in word-formation compared across children and languages, and general semantic and pragmatic issues in the lexicon and in language use. I am currently working on the kinds of pragmatic information adults offer small children as they talk to them, and on children's ability to make use of this information as they make inferences about unfamiliar meanings and about the relations between familiar and unfamiliar words. I am interested in the inferences children make about where to 'place' unfamiliar words, how they identify the relevant semantic domains, and what they can learn about conventional ways to say things based on adult responses to child errors during acquisition. All of these 'activities' involve children and adults placing information in common ground as they interact. Another current interest of mine is the construction of verb paradigms: how do children go from using a single verb form to using forms that contrast in meaning -- on such dimensions as person, number, and tense? How do they learn to distinguish the meanings of homophones? To what extent do they make use of adult input to discern the underlying structure of the system? And how does conversation with more expert speakers (usually adults) foster the acquisition of a first language? I am particularly interested in the general role of practice along with feedback here.
