Wu Tsai Neurosciences Institute
Showing 41-46 of 46 Results
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Ximena Corso Díaz
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in unraveling the roles of RNA-binding proteins (RBPs) and regulatory RNAs in retinal development and homeostasis.
RNA-binding proteins mediate functional integration of transcriptional and post-transcriptional machineries influencing various aspects of gene expression and RNA metabolism. Several RBPs have cell-type enriched expression patterns in the retina or cause blinding diseases, however their role in retinal development and function is poorly understood. We have identified several RBPs that interact with the photoreceptor-specific transcription factor NRL and are likely involved in development and homeostasis of this retinal cell-type. We are pursuing the following lines of research:
1) RBPs in retinal development and degeneration. We will study the role of RBPs in regulating retinal development and maintaining homeostasis. We will focus on RBPs enriched in the retina, their interactions with retinal transcription factors like NRL, and their relevance to retinal diseases.
2) RBPs in R-loop regulation in the retina. R-loops are triple-stranded structures created when RNA anneals to one of the strands of the DNA duplex. R-loops have many regulatory roles during gene expression and their dysregulation can be detrimental to genome integrity. We observed that R-loops are dynamic during retinal development and identified key R-loop-associated RBPs that are enriched in rod photoreceptors and that interact with the transcription factor NRL. We will study the role of R-loops and their regulatory RBPs in retinal development and homeostasis.
3) Chromatin-associated regulatory RNAs through the retina lifespan. Chromatin-associated RNAs contribute to the dynamic regulation of gene expression, chromatin structure, and genome organization, playing essential roles in various biological processes, including development, differentiation, and disease. We will study how regulatory RNAs, together with their cognate RBPs, influence expression programs and chromatin dynamics through the retina lifespan. -
Graham Creasey
Paralyzed Veterans of America Professor of Spinal Cord Injury Medicine, Emeritus
Current Research and Scholarly InterestsNeural prostheses to stimulate and record from the peripheral and central nervous system, thereby directly connecting nervous systems with electronic systems
Neural prostheses for control of bladder, bowel and sexual function after spinal cord injury -
Bianxiao Cui
Job and Gertrud Tamaki Professor of Chemistry
Current Research and Scholarly InterestsOur objective is to develop new biophysical methods to advance current understandings of cellular machinery in the complicated environment of living cells. Currently, we are focusing on four research areas: (1) Membrane curvature at the nano-bio interface; (2) Nanoelectrode arrays (NEAs) for scalable intracellular electrophysiology; (3) Electrochromic optical recording (ECORE) for neuroscience; and (4) Optical control of neurotrophin receptor tyrosine kinases.
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Yi Cui
Fortinet Founders Professor, Professor of Materials Science and Engineering, of Energy Science and Engineering, of Photon Science, Senior Fellow at Woods, at Precourt and Professor, by courtesy, of Chemistry
BioCui studies fundamentals and applications of nanomaterials and develops tools for their understanding. Research Interests: nanotechnology, batteries, electrocatalysis, wearables, 2D materials, environmental technology (water, air, soil), cryogenic electron microscopy.
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Mark Cutkosky
Fletcher Jones Professor in the School of Engineering
BioCutkosky applies analyses, simulations, and experiments to the design and control of robotic hands, tactile sensors, and devices for human/computer interaction. In manufacturing, his work focuses on design tools for rapid prototyping.
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Meg Cychosz
Assistant Professor of Linguistics
BioDr. Cychosz investigates how infants and children develop speech and language, including children who are d/Deaf or hard-of-hearing and multilingual learners. Her research bridges linguistics, cognitive science, developmental psychology, and electrical engineering to understand fundamental questions about language acquisition. Her interdisciplinary approach combines fieldwork with computational methods, using deep learning and automatic speech recognition tools to analyze naturalistic speech recordings from children's daily lives. She is particularly interested in how children's processing limitations might influence the structure of the world's languages, how sensory experiences like hearing loss affect language processing in early childhood, and how technological innovations can make language research more accessible and representative. Dr. Cychosz directs the Speech and Cognitive Development Lab and collaborates with clinical partners in audiology and speech-language pathology to ensure her research has translational impact to support children's language development.