Vice Provost and Dean of Research
Showing 541-550 of 1,155 Results
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Yong Yean Kim
Assistant Professor of Pediatrics ( Hematology & Oncology)
BioOur lab is interested in translational science to bring new therapies to clinical trials. In particular, we are interested in pediatric sarcomas which have not had advancement in clinical treatment for decades. Current projects in the lab focus on understanding of the biology of fusion transcription factor PAX3::FOXO1 which is the driver mutation in fusion positive rhabdomyosarcoma. PAX3::FOXO1 is a powerful oncogenic transcription factor which rewires the transcriptional organization to lock the cancer cell in the proliferative state. Since transcription factors including PAX3::FOXO1 are difficult to target using small molecules, we aim to understand how PAX3::FOXO1 is regulated and targeting the regulators of PAX3::FOXO1. By understanding and targeting the regulation of PAX3::FOXO1, we hope to bring new therapies for fusion positive rhabdomyosarcoma. Additionally, these regulatory mechanisms may also be active in other transcription driven cancers such as the EWSR1::FLI1 driven Ewings Sarcoma.
Our lab is also interested in exploring the epigenetic landscape of pediatric solid tumors and trying to understand how dysregulation in the epigenome drives oncogenesis. We utilize various CRISPR mediated genetic techniques to interrogate the regulators of epigenome focusing on the histone lysine demethylases (KDMs). KDMs are an understudied group of epigenetic regulators which can be targeted for therapeutic effect. We explore the role of KDMs in pediatric solid tumors and hope to identify potential targets for drug development. -
David Kingsley
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine
Current Research and Scholarly InterestsWe use mice, stickleback fish, and humans to study the molecular basis of evolution and common diseases. By combining genetics and genomics, we have identified key DNA changes that control bone formation, limb patterning, hair color, brain evolution, and susceptibility to arthritis, schizophrenia, and bipolar disorder. We find that the same genetic mechanisms are often used repeatedly in nature, providing new insights into the origin of key traits in many different species, including ourselves.
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Amanda Kirane, MD, PhD, FACS, FSSO
Associate Professor of Surgery (General Surgery)
BioDr. Kirane is a fellowship-trained, board-certified specialist in complex general surgical oncology. She is an Assistant Professor in the Department of Surgery, Section of Surgical Oncology, at Stanford University School of Medicine. Dr. Kirane serves as Director of Cutaneous Surgical Oncology at the Stanford Cancer Center and her clinical practice focuses on the diagnosis and treatment of melanoma and other skin cancers. She partners closely with patients and families to provide the most effective treatment approach possible. For each patient, she tailors an evidence-based, personalized care plan that is innovative, comprehensive, and compassionate.
Dr. Kirane is Principal Investigator of multiple studies in melanoma and mechanisms of resistance to immunotherapy, with focus on myeloid biology. Her current interests include immune response and novel therapies in melanoma, predictive modeling of patient responses using organoid technology, and translational biomarker development. She has led research into immune therapy for earlier stage melanoma using regionally directed therapy to augment immune response in melanoma and trials in surgical care in melanoma.
The National Institutes of Health, American Society of Clinical Oncology, the Melanoma Research Alliance, and others have funded her research. She has co-authored articles on her discoveries in the Journal of Clinical Investigation, Nature Communications, Nature Genetics, Cancer Research, Journal of Surgical Oncology, Annals of Surgery, Annals of Surgical Oncology, and elsewhere. Topics include intratumoral therapy, biomarker development, macrophage biology in melanoma and immunotheraputic resistance, and patient-derived organoid modeling. Dr. Kirane has presented updates on the management of melanoma and other cancers to her peers at meetings of the American College of Surgeons, Society of Surgical Oncology, and Society for Immunotherapy in Cancer.
Dr. Kirane has earned awards for her achievements in clinical care, research, and scholarship. The Society for Immunotherapy of Cancer, Society of Surgical Oncology, Memorial Sloan Kettering Cancer Center, and other prestigious organizations have honored her work. She is a fellow of the American College of Surgeons (FACS) and Society of Surgical Oncology (FSSO). She is a member of the Society for Immunotherapy of Cancer, American Association of Cancer Research, Society for Melanoma Research, Connective Tissue Oncology Society, Association of Academic Surgeons, and Association of Women Surgeons.
She volunteers her time and expertise on behalf of the Melanoma Research Foundation, members of her community in need, STEM programs for girls, and other initiatives. She also is fellowship trained in Physician Wellness and Wellbeing and teaches somatic technique, mindfulness-based stress reduction, meditation, and breathwork. -
Varvara A. Kirchner
Associate Professor of Surgery (Abdominal Transplantation) and, by courtesy, of Pediatrics
BioDr. Kirchner completed her medical school, surgical residency and multi-organ transplant fellowship in adult and pediatric liver, pancreas, kidney transplantation and total pancreatectomy with islet auto-transplantation at the University of Minnesota. She underwent further training in living donor liver transplantation and hepatobiliary surgery at the Asan Medical Center, Seoul, South Korea. Her clinical practice involves living and deceased donor liver and kidney transplantation in adult and pediatric patients as well as total pancreatectomy with islet auto-transplantation for patients with chronic and acute recurrent pancreatitis. She currently serves as Surgical Director of the Islet Cell Auto-Transplant at Stanford Children’s and Associate Director of the Living Donor Liver Transplant Program at the Division of Abdominal Transplantation. Dr. Kirchner’s research focuses on the biology of aging, cellular and solid organ transplantation. Her specific interests are in auto-islet transplantation, iPSC-derived hepatocyte therapies and liver regeneration. Dr. Kirchner's research on the impact of donor age on generation of iPSC-derived hepatocyte-like cells is supported by the NIA K08 Faculty Development Award. She is an active member of the American Society of Transplant Surgeons and the International Liver Transplantation Society.
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Karla Kirkegaard
Violetta L. Horton Professor and Professor of Microbiology and Immunology
Current Research and Scholarly InterestsThe biochemistry of RNA-dependent RNA polymerase function, the cell biology of the membrane rearrangements induced by positive-strand RNA virus infection of human cells, and the genetics of RNA viruses, which, with their high error rates, live at the brink of error catastrophe, are investigated in the Kirkegaard laboratory.
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Peter K. Kitanidis
Professor of Civil and Environmental Engineering
BioKitanidis develops methods for the solution of interpolation and inverse problems utilizing observations and mathematical models of flow and transport. He studies dilution and mixing of soluble substances in heterogeneous geologic formations, issues of scale in mass transport in heterogeneous porous media, and techniques to speed up the decay of pollutants in situ. He also develops methods for hydrologic forecasting and the optimization of sampling and control strategies.
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Jonathan D Klein
Marron and Mary Elizabeth Kendrick Professor of Pediatrics
Current Research and Scholarly InterestsMy studies address:
1. Confidentiality and Access to Care studies of confidential time during well-visits and policy analyses addressing quality of care and health systems capacity for adolescents and young adults in the US and globally; and,
2, Tobacco, nicotine, and second-hand smoke studies of primary care counseling to reduce nicotine addiction in adolescents and programs to engage medical specialty groups in secondhand smoke clinical and policy interventions. -
Matthias Kling
Director, PULSE Institute, Professor of Photon Science and, by courtesy, of Applied Physics
Current Research and Scholarly InterestsKling's research focuses on ultrafast electronics and nanophotonics employing ultrashort flashes of light from table-top and free-electron laser sources.
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Joshua W. Knowles
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsGenetic basis of coronary disease
Genetic basis of insulin resistance
Familial Hypercholesterolemia (FH) -
Juliet Klasing Knowles
Assistant Professor of Neurology and Neurological Sciences (Pediatric Neurology) and of Pediatrics
Current Research and Scholarly InterestsThe Knowles lab studies how white matter structure changes in different forms of epilepsy, and how aberrant white matter structure, in turn, shapes neuronal network function. In mouse models, we use a variety of innovative tools including neurophysiology, quantitative EEG, behavior, histological measures of white matter structure and MR imaging. We also conduct clinical research to study white matter abnormalities in children with epilepsy.