Chantal Aivan Le
Masters Student in Computer Science, admitted Autumn 2023
Student Employee, Computer Science
All Publications
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Four Neotropical frog species exhibit shared and distinct skin bacterial communities in a laboratory setting.
microPublication biology
2026; 2026
Abstract
Amphibian skin microbiomes are an essential part of host physiology and pathogen defense. In this study, we identified common and distinct microbiota across four Neotropical frog species in laboratory conditions. Across frogs, we found communities dominated by Pseudomonas and Chryseobacterium . However, each frog species had a unique bacterial profile with at least one unique bacterial genus, highlighting the variability of naturally occurring amphibian skin microbiomes. These experiments were conducted by undergraduate students in an upper-division laboratory course, demonstrating how curiosity-based science education can lead to practical research experiences and new scientific insights.
View details for DOI 10.17912/micropub.biology.002080
View details for PubMedID 41890544
View details for PubMedCentralID PMC13014139
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Bay leaf extract is a chemotaxis repellent for C. elegans.
microPublication biology
2026; 2026
Abstract
Plants synthesize compounds that modulate animal nervous systems through various mechanisms, but the key interactions remain understudied. We used chemotaxis assays with the nematode Caenorhabditis elegans to test if plant extracts can be detected by the worm nervous system and which compounds induce behavioral responses. We found that C. elegans avoid the extract of bay leaves ( Laurus nobilis ). Subsequent testing of known bay leaf compounds identified cadinene and eugenol as key molecules that may mediate the repulsion effect. These experiments were conducted by undergraduate students in an upper-division laboratory course, providing practical research experiences and new insights into plant-animal interactions.
View details for DOI 10.17912/micropub.biology.002023
View details for PubMedID 41867891
View details for PubMedCentralID PMC13005153
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3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.
bioRxiv : the preprint server for biology
2025
Abstract
3D bioprinting has revolutionized tissue engineering, enabling intricate, physiologically relevant constructs unattainable with conventional techniques, yet it remains limited in integrating soft and rigid multifunctional components for complex multi-tissue applications. In this study, we introduce a 3D hybrid bioprinting approach implementing the Hybprinter platform, which integrates multiple 3D printing modules under optimized conditions for a continuous bioprinting process with multiple soft and hard biomaterials. This approach demonstrates robust biocompatibility and broad tissue engineering potential for modeling and therapeutic applications. The capacity to fabricate multi-hydrogel hybrid constructs is illustrated by representative examples highlighting vascularization, multifunctionality, mechanical robustness, and implant suturability. Notably, compared with commonly fabricated hydrogel-only constructs, the resulting hybrid constructs achieve over a 1000-fold increase in mechanical strength, and demonstrated enhanced osteogenic differentiation, underscoring their suitability for load-bearing musculoskeletal and orthopedic tissue engineering. Additionally, cell-laden hydrogel constructs demonstrated robust chondrogenic differentiation, highlighting the capacity for lineage-specific tissue development in vitro. Beyond these outcomes, the presented hybrid bioprinting approach integrates essential tissue engineering attributes that unites mechanical robustness and suturable capacity with multi-material integration, gradient property design, incorporation of bioactive agents, and support for multi-cell loading. This versatile platform advances complex tissue engineering and holds promise for patient specific, organ-on-demand applications.
View details for DOI 10.1101/2025.11.06.682452
View details for PubMedID 41278903
View details for PubMedCentralID PMC12637617