Dr. Minh Nguyen joined the Prof. Jeffrey Glenn laboratory as a postdoctoral scholar in August 2022. In collaboration with Safaran ChEM-H Medicinal Chemistry Knowledge Center, his research objective is to harness the power of organic synthesis toward the development of novel antiviral therapies. Minh obtained his Ph.D. in Chemistry from the University of Pennsylvania under the direction of Prof. Amos B. Smith, III, where his doctoral work centered on the convergent total synthesis of two marine natural products nahuoic acids Cii and Dii.
Honors & Awards
Graduate Fellowship, Vietnam Education Foundation (VEF) (2016)
PhD, University of Pennsylvania, Chemistry (2022)
BSc, Ho Chi Minh University of Medicine and Pharmacy, Vietnam, Pharmacy (2015)
Generation of Dithianyl and Dioxolanyl Radicals Using Photoredox Catalysis: Application in the Total Synthesis of the Danshenspiroketallactones via Radical Relay Chemistry
2019; 21 (6): 1708-1712
Visible-light-induced generation of dithianyl and dioxolanyl radicals via selective hydrogen atom transfer (HAT) has been achieved. This radical relay tactic enables remote C(sp3)-H functionalization to permit rapid access to polyol and spiroketal segments, and in turn has been exploited as a key synthetic construct in the total synthesis of the danshenspiroketallactones. The conformational stability of the danshenspiroketallactones has also been defined via experiments and DFT calculations.
View details for DOI 10.1021/acs.orglett.9b00271
View details for Web of Science ID 000461843900034
View details for PubMedID 30807194
View details for PubMedCentralID PMC6518407
- Synthesis of Novel Chalcones as Acetylcholinesterase Inhibitors APPLIED SCIENCES-BASEL 2016; 6 (7)
Synthesis and Selective Cytotoxic Activities on Rhabdomyosarcoma and Noncancerous Cells of Some Heterocyclic Chalcones
2016; 21 (3): 329
Chemically diverse heterocyclic chalcones were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against rhabdomyosarcoma (RMS) and noncancerous cell line (LLC-PK1). The influence of heteroaryl patterns on rings A and B was studied. Heterocycle functionalities on both rings, such as phenothiazine, thiophene, furan and pyridine were evaluated. Notably, the introduction of three methoxy groups at positions 3, 4, 5 on ring B appears to be critical for cytotoxicity. The best compound, with potent and selective cytotoxicity (IC50 = 12.51 μM in comparison with the value 10.84 μM of paclitaxel), contains a phenothiazine moiety on ring A and a thiophene heterocycle on ring B. Most of the potential compounds only show weak cytoxicity on the noncancerous cell line LLC-PK1.
View details for DOI 10.3390/molecules21030329
View details for Web of Science ID 000373802200035
View details for PubMedID 27005608
View details for PubMedCentralID PMC6273843