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    University - Student Department: School of Medicine Position: Graduate, Medicine

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  • Reductively Stable Hydrogen-Bonding Ligands Featuring Appended CF2-H Units JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Shanahan, J. P., Mullis, D. M., Zeller, M., Szymczak, N. K. 2020; 142 (19): 8809–17

    Abstract

    We present the development of ligands featuring the unconventional hydrogen bond donor, -CF2H, within a metal's secondary coordination sphere. When metalated with palladium, o-CF2H-functionalized 1,10-phenanthroline provides highly directed H-bonding interactions with Pd-coordinated substrates. Spectroscopic and computational analyses with a series of X-type ligand acceptors (-F, -Cl, -Br, -OR) establish the H-bonding interaction strength for the -CF2H group (∼3 kcal/mol). The synthesis of Pd0/Ni0 complexes and subsequent coupling (Ni) highlight the unique reductive and base compatibility of the -CF2H hydrogen bond donor group.

    View details for DOI 10.1021/jacs.0c01718

    View details for Web of Science ID 000535252100035

    View details for PubMedID 32352797