Davide Momi

All Publications

• Reliability of resting-state EEG modulation by continuous and intermittent theta burst stimulation of the primary motor cortex: a sham-controlled study. Scientific reports Rodionov, A., Ozdemir, R. A., Benwell, C. S., Fried, P. J., Boucher, P., Momi, D., Ross, J. M., Santarnecchi, E., Pascual-Leone, A., Shafi, M. M. 2023; 13 (1): 18898

  Abstract

  Theta burst stimulation (TBS) is a form of repetitive transcranial magnetic stimulation designed to induce changes of cortical excitability that outlast the period of TBS application. In this study, we explored the effects of continuous TBS (cTBS) and intermittent TBS (iTBS) versus sham TBS stimulation, applied to the left primary motor cortex, on modulation of resting state electroencephalography (rsEEG) power. We first conducted hypothesis-driven region-of-interest (ROI) analyses examining changes in alpha (8-12Hz) and beta (13-21Hz) bands over the left and right motor cortex. Additionally, we performed data-driven whole-brain analyses across a wide range of frequencies (1-50Hz) and all electrodes. Finally, we assessed the reliability of TBS effects across two sessions approximately 1month apart. None of the protocols produced significant group-level effects in the ROI. Whole-brain analysis revealed that cTBS significantly enhanced relative power between 19 and 43Hz over multiple sites in both hemispheres. However, these results were not reliable across visits. There were no significant differences between EEG modulation by active and sham TBS protocols. Between-visit reliability of TBS-induced neuromodulatory effects was generally low-to-moderate. We discuss confounding factors and potential approaches for improving the reliability of TBS-induced rsEEG modulation.

  View details for DOI 10.1038/s41598-023-45512-6

  View details for PubMedID 37919322

• Reliability of resting-state EEG modulation by continuous and intermittent theta burst stimulation of the primary motor cortex: A sham-controlled study. bioRxiv : the preprint server for biology Rodionov, A., Ozdemir, R. A., Benwell, C. S., Fried, P. J., Boucher, P., Momi, D., Ross, J. M., Santarnecchi, E., Pascual-Leone, A., Shafi, M. M. 2023

  Abstract

  Theta burst stimulation (TBS) is a form of repetitive transcranial magnetic stimulation designed to induce changes of cortical excitability that outlast the period of TBS application. In this study, we explored the effects of continuous TBS (cTBS) and intermittent TBS (iTBS) versus sham TBS stimulation, applied to the primary motor cortex, on modulation of resting state electroencephalography (rsEEG) power. We first conducted hypothesis-driven region-of-interest (ROI) analyses examining changes in alpha (8-12 Hz) and beta (13-21 Hz) bands over the left and right motor cortex. Additionally, we performed data-driven whole-brain analyses across a wide range of frequencies (1-50 Hz) and all electrodes. Finally, we assessed the reliability of TBS effects across two sessions approximately 1 month apart. None of the protocols produced significant group-level effects in the ROI. Whole-brain analysis revealed that cTBS significantly enhanced relative power between 19-43 Hz over multiple sites in both hemispheres. However, these results were not reliable across visits. There were no significant differences between EEG modulation by active and sham TBS protocols. Between-visit reliability of TBS-induced neuromodulatory effects was generally low-to-moderate. We discuss confounding factors and potential approaches for improving the reliability of TBS-induced rsEEG modulation.

  View details for DOI 10.1101/2023.05.12.540024

  View details for PubMedID 37215043

• Identifying Neurophysiological Markers of Intermittent Theta-Burst Stimulation in Treatment-Resistant Depression using Transcranial Magnetic Stimulation- Electroencephalography. Biological psychiatry Strafella, R., Momi, D., Zomorrodi, R., Lissemore, J., Noda, Y., Chen, R., Rajji, T. K., Griffiths, J. D., Vila-Rodriguez, F., Downar, J., Daskalakis, Z. J., Blumberger, D. M., Voineskos, D. 2023

  Abstract

  Intermittent theta-burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (L-DLPFC) is effective for treatment-resistant depression (TRD), but iTBS' effects on neurophysiological markers remains unclear. Here, we indexed transcranial magnetic stimulation-electroencephalography (TMS-EEG) markers, specifically, the N45 and N100 amplitudes, at baseline and post-iTBS, comparing separated and contiguous iTBS schedules. TMS-EEG markers were also compared between iTBS responders and non-responders.TMS-EEG was analyzed from a triple-blind 1:1 randomized trial for TRD, comparing a separated (54 min interval) and contiguous (0 min interval) schedule of 2x600 pulse iTBS for 30 treatments. Participants underwent TMS-EEG over the L-DLPFC at baseline and post-treatment. 114 participants had usable TMS-EEG at baseline, and 98 at post-treatment. TMS-evoked potential (TEP) components (N45, N100) were examined via global mean-field analysis.The N100 amplitude decreased from baseline to post-treatment regardless of treatment group (F(1, 106) = 5.20, p = 0.02). There were no changes in N45 amplitude in either treatment group. In responders, the N100 amplitude decreased after iTBS (F(1,102) = 11.30, p = 0.001, pcorrected= 0.0004). Responders showed higher post-treatment N45 amplitude than non-responders (F(1, 94) = 4.11, p = 0.045, pcorrected= 0.016). Higher baseline N100 amplitude predicted lower post-iTBS depression scores (F(4, 106) = 6.28, p = 0.00014).These results further the evidence for an association between neurophysiological effects of iTBS and treatment efficacy in TRD. Future studies are needed to test the predictive potential for clinical applications of TMS-EEG markers.

  View details for DOI 10.1016/j.biopsych.2023.04.011

  View details for PubMedID 37084864

• A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement. Nature protocols Ekhtiari, H., Ghobadi-Azbari, P., Thielscher, A., Antal, A., Li, L. M., Shereen, A. D., Cabral-Calderin, Y., Keeser, D., Bergmann, T. O., Jamil, A., Violante, I. R., Almeida, J., Meinzer, M., Siebner, H. R., Woods, A. J., Stagg, C. J., Abend, R., Antonenko, D., Auer, T., Bachinger, M., Baeken, C., Barron, H. C., Chase, H. W., Crinion, J., Datta, A., Davis, M. H., Ebrahimi, M., Esmaeilpour, Z., Falcone, B., Fiori, V., Ghodratitoostani, I., Gilam, G., Grabner, R. H., Greenspan, J. D., Groen, G., Hartwigsen, G., Hauser, T. U., Herrmann, C. S., Juan, C., Krekelberg, B., Lefebvre, S., Liew, S., Madsen, K. H., Mahdavifar-Khayati, R., Malmir, N., Marangolo, P., Martin, A. K., Meeker, T. J., Ardabili, H. M., Moisa, M., Momi, D., Mulyana, B., Opitz, A., Orlov, N., Ragert, P., Ruff, C. C., Ruffini, G., Ruttorf, M., Sangchooli, A., Schellhorn, K., Schlaug, G., Sehm, B., Soleimani, G., Tavakoli, H., Thompson, B., Timmann, D., Tsuchiyagaito, A., Ulrich, M., Vosskuhl, J., Weinrich, C. A., Zare-Bidoky, M., Zhang, X., Zoefel, B., Nitsche, M. A., Bikson, M. 2022

  Abstract

  Low-intensity transcranial electrical stimulation (tES), including alternating or direct current stimulation, applies weak electrical stimulation to modulate the activity of brain circuits. Integration of tES with concurrent functional MRI (fMRI) allows for the mapping of neural activity during neuromodulation, supporting causal studies of both brain function and tES effects. Methodological aspects of tES-fMRI studies underpin the results, and reporting them in appropriate detail is required for reproducibility and interpretability. Despite the growing number of published reports, there are no consensus-based checklists for disclosing methodological details of concurrent tES-fMRI studies. The objective of this work was to develop a consensus-based checklist of reporting standards for concurrent tES-fMRI studies to support methodological rigor, transparency and reproducibility (ContES checklist). A two-phase Delphi consensus process was conducted by a steering committee (SC) of 13 members and 49 expert panelists through the International Network of the tES-fMRI Consortium. The process began with a circulation of a preliminary checklist of essential items and additional recommendations, developed by the SC on the basis of a systematic review of 57 concurrent tES-fMRI studies. Contributors were then invited to suggest revisions or additions to the initial checklist. After the revision phase, contributors rated the importance of the 17 essential items and 42 additional recommendations in the final checklist. The state of methodological transparency within the 57 reviewed concurrent tES-fMRI studies was then assessed by using the checklist. Experts refined the checklist through the revision and rating phases, leading to a checklist with three categories of essential items and additional recommendations: (i) technological factors, (ii) safety and noise tests and (iii) methodological factors. The level of reporting of checklist items varied among the 57 concurrent tES-fMRI papers, ranging from 24% to 76%. On average, 53% of checklist items were reported in a given article. In conclusion, use of the ContES checklist is expected to enhance the methodological reporting quality of future concurrent tES-fMRI studies and increase methodological transparency and reproducibility.

  View details for DOI 10.1038/s41596-021-00664-5

  View details for PubMedID 35121855