Professional Education


  • Ingeniero, Universidad De Chile (2013)
  • Licenciado, Universidad De Chile (2018)
  • Doctor of Philosophy, University of Manchester (2018)

Stanford Advisors


All Publications


  • CoFe granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation BioRxive Morales-Polanco, F., Bates, C., Lui, J., Casson, J., Solari, C. A., Pizzinga, M., Forte, G., Griffin, C., Portela, P., Ashe, M. P. 2019

    View details for DOI 10.1101/741231

  • Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth. The Journal of cell biology Pizzinga, M., Bates, C., Lui, J., Forte, G., Morales-Polanco, F., Linney, E., Knotkova, B., Wilson, B., Solari, C. A., Berchowitz, L. E., Portela, P., Ashe, M. P. 2019

    Abstract

    mRNA localization serves key functions in localized protein production, making it critical that the translation machinery itself is present at these locations. Here we show that translation factor mRNAs are localized to distinct granules within yeast cells. In contrast to many messenger RNP granules, such as processing bodies and stress granules, which contain translationally repressed mRNAs, these granules harbor translated mRNAs under active growth conditions. The granules require Pab1p for their integrity and are inherited by developing daughter cells in a She2p/She3p-dependent manner. These results point to a model where roughly half the mRNA for certain translation factors is specifically directed in granules or translation factories toward the tip of the developing daughter cell, where protein synthesis is most heavily required, which has particular implications for filamentous forms of growth. Such a feedforward mechanism would ensure adequate provision of the translation machinery where it is to be needed most over the coming growth cycle.

    View details for DOI 10.1083/jcb.201704019

    View details for PubMedID 30877141