Professional Education


  • Ph.D., Isfahan University of Technology, Organic-Polymer Chemistry (2019)

Stanford Advisors


Graduate and Fellowship Programs


  • Stanford Cancer Imaging Training Program (SCIT) (Fellowship Program)

All Publications


  • Recent advances in magnetic semiconductor ZnFe2O4 nanoceramics: History, properties, synthesis, characterization, and applications JOURNAL OF SOLID STATE CHEMISTRY Tabesh, F., Mallakpour, S., Hussain, C. 2023; 322
  • Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging. International journal of molecular sciences Bam, R., Natarajan, A., Tabesh, F., Paulmurugan, R., Dahl, J. J. 2023; 24 (10)

    Abstract

    The main aim of this study is to synthesize contrast microbubbles (MB) functionalized with engineered protein ligands using a microfluidic device to target breast cancer specific vascular B7-H3 receptor in vivo for diagnostic ultrasound imaging. We used a high-affinity affibody (ABY) selected against human/mouse B7-H3 receptor for engineering targeted MBs (TMBs). We introduced a C-terminal cysteine residue to this ABY ligand for facilitating site-specific conjugation to DSPE-PEG-2K-maleimide (M. Wt = 2.9416 kDa) phospholipid for MB formulation. We optimized the reaction conditions of bioconjugations and applied it for microfluidic based synthesis of TMBs using DSPE-PEG-ABY and DPPC liposomes (5:95 mole %). The binding affinity of TMBs to B7-H3 (MBB7-H3) was tested in vitro in MS1 endothelial cells expressing human B7-H3 (MS1B7-H3) by flow chamber assay, and by ex vivo in the mammary tumors of a transgenic mouse model (FVB/N-Tg (MMTV-PyMT)634Mul/J), expressing murine B7-H3 in the vascular endothelial cells by immunostaining analyses. We successfully optimized the conditions needed for generating TMBs using a microfluidic system. The synthesized MBs showed higher affinity to MS1 cells engineered to express higher level of hB7-H3, and in the endothelial cells of mouse tumor tissue upon injecting TMBs in a live animal. The average number (mean ± SD) of MBB7-H3 binding to MS1B7-H3 cells was estimated to be 354.4 ± 52.3 per field of view (FOV) compared to wild-type control cells (MS1WT; 36.2 ± 7.5/FOV). The non-targeted MBs did not show any selective binding affinity to both the cells (37.7 ± 7.8/FOV for MS1B7-H3 and 28.3 ± 6.7/FOV for MS1WT cells). The fluorescently labeled MBB7-H3 upon systemic injection in vivo co-localized to tumor vessels, expressing B7-H3 receptor, as validated by ex vivo immunofluorescence analyses. We have successfully synthesized a novel MBB7-H3 via microfluidic device, which allows us to produce on demand TMBs for clinical applications. This clinically translatable MBB7-H3 showed significant binding affinity to vascular endothelial cells expressing B7-H3 both in vitro and in vivo, which shows its potential for clinical translation as a molecular ultrasound contrast agent for human applications.

    View details for DOI 10.3390/ijms24109048

    View details for PubMedID 37240396

  • Removal of the environmental pollutant methylene blue using bio-nanohydrogel nanocomposite containing tragacanth gum and vitamin C-functionalized carbon nanotube POLYMER BULLETIN Tabesh, F., Mallakpour, S. 2024; 81 (2): 1513-1527
  • Water decontamination using CaCO3 nanostructure and its nanocomposites: current advances Polymer Bulletin Tabesh, F. 2023; 80
  • Potential of tragacanth gum in the industries: a short journey from past to the future POLYMER BULLETIN Mallakpour, S., Tabesh, F., Hussain, C. 2023; 80 (5): 4643-4662
  • A new trend of using poly(vinyl alcohol) in 3D and 4D printing technologies: Process and applications. Advances in colloid and interface science Mallakpour, S., Tabesh, F., Hussain, C. M. 2022; 301: 102605

    Abstract

    Recently, 3D/4D printing technologies have been the researchers' interest, and they are getting improved more important. They are applicable in various fields like medical fields, pharmaceutics, construction, tissue engineering, dentistry, water treatment, etc. These technologies overcame the difficulty of the conventional methods in producing complicated structures. They can be fed by different materials such as nanomaterials, smart polymers, responsive polymers, metamaterials, synthetic polymers, natural polymers, and so forth. One of the smart and stimuli-responsive polymers is poly(vinyl alcohol) (PVA). In addition to numerous applications of PVA like medicine, environmental fields, etc., researchers are showing a tendency to use PVA in 3D/4D printing technologies. The main reasons for PVA's increased interest in 3D/4D printing technologies are suitable flowability, stimuli-responsivity, extrudability, biocompatibility, biodegradability, cost-effectiveness, and other features. This review aims to introduce the 3D/4D printing technologies' knowledge and then the applications of PVA as a feed in these novel technologies.

    View details for DOI 10.1016/j.cis.2022.102605

    View details for PubMedID 35144173

  • Effective adsorption of methylene blue dye from water solution using renewable natural hydrogel bionanocomposite based on tragacanth gum: Linear-nonlinear calculations. International journal of biological macromolecules Mallakpour, S., Tabesh, F. 2021; 187: 319-324

    Abstract

    Today, hydrogels opened new windows to the high-tech due to their amazing features. Thus, we applied hydrogel nanocomposite (HNC) made of tragacanth gum (a kind of polysaccharide) and CaCO3 nanoparticles to remove methylene blue dye (MBD) from the water solution. We used nonlinear and linear isotherms and kinetics as well as thermodynamics to uncover the adsorption mechanism. The results showed that the hydrogel could remove 80% of MBD. Besides, the linear form of the pseudo-second-order kinetic model fits well with the results, showing chemical interactions. We found that this process follows both Sips and Redlich-Peterson models by applying nonlinear and linear isotherm models. The maximum adsorption capacities from nonlinear and linear Sips were 1401 and 2145 mg/g, respectively. Based on the thermodynamic equations, the adsorption of MBD onto HNC was physiochemical and exothermic. According to the phenomenological calculations, diffusion from the bulk (or film diffusion, Df = 1.2 × 10-8 cm2/s) is the primary mechanism.

    View details for DOI 10.1016/j.ijbiomac.2021.07.105

    View details for PubMedID 34298053

  • 3D and 4D printing: From innovation to evolution. Advances in colloid and interface science Mallakpour, S., Tabesh, F., Hussain, C. M. 2021; 294: 102482

    Abstract

    The world and science are moving forward nonstop. Every day, we see novel technologies that are coming to improve life quality. One of them is 3D printing or additive manufacturing. This technology covers the shortage of the current manufacturing technologies, and it has been enhanced by introducing smart materials like smart polymers as feed. The following product can adapt to circumstance conditions such as temperature changes, compression alteration, etc. These responses resulted in an advanced 3D printing technology called 4D printing. 3D and 4D printing technologies found their applications in all areas and industry sizes, from home-scale to large-scale industries. Regardless of all advantages of these technologies, there are still some shortages like low printing speed. But this never stops their progression and promotion. In this review, we aimed to cover general knowledge about 3D and 4D printing and their recent applications in various fields.

    View details for DOI 10.1016/j.cis.2021.102482

    View details for PubMedID 34274721

  • Renewable bionanohydrogels based on tragacanth gum for the adsorption of Pb<SUP>2+</SUP>: Study of isotherm, kinetic models, and phenomenology ENVIRONMENTAL TECHNOLOGY & INNOVATION Mallakpour, S., Tabesh, F. 2021; 23
  • Green and plant-based adsorbent from tragacanth gum and carboxyl-functionalized carbon nanotube hydrogel bionanocomposite for the super removal of methylene blue dye. International journal of biological macromolecules Mallakpour, S., Tabesh, F. 2021; 166: 722-729

    Abstract

    This study aims to prepare a hydrogel bionanocomposite (HBNC) as an efficient adsorbent and introduce it as a suitable replacement for petroleum-based adsorbents. Thus, tragacanth gum (TG), and carboxyl-functionalized carbon nanotube (CFCNT) were used as raw materials. HBNCs were prepared with the aid of ultrasonication, and different methods were employed to characterize them. The surface structures of the HBNCs were altered after the addition CFCNT into TG and exposure to ultrasound, as well. Transmission electron microscopy images showed CFCNTs were well dispersed in TG. Then, the adsorption of methylene blue (MB) was performed using these HBNCs. The removal efficiency was over 80% at optimized conditions. Nonlinear and linear forms of Langmuir, Freundlich, Dubinin-Radushkevich, Sips, and Redlich-Peterson (R-P) were applied to find the proper arrangement of MB onto the adsorbent. Using statistical equations, it was revealed that the process obeyed the linear R-P model, indicating a mixture of mono- and multilayer adsorption (but mostly monolayer). Also, pseudo-second-order was the appropriate kinetic model and suggested chemical adsorption. According to the thermodynamic calculations, this process was exothermic and spontaneous, and the type of interactions between HBNC and MB was physicochemical. Also, the diffusion study indicated that film diffusion is the primary mechanism.

    View details for DOI 10.1016/j.ijbiomac.2020.10.229

    View details for PubMedID 33137386

  • Metal oxides and biopolymer/metal oxides bionanocomposites as green nanomaterials for heavy metals removal Nanotoxicology and Nanoecotoxicology Tabesh, F. 2021
  • Natural polymer-based organic-inorganic hybrid nanosorbents Natural Polymers-Based Green Adsorbents for Water Treatment Tabesh, F. 2021
  • Application of gum polysaccharides nanocomposites in the removal of industrial organic and inorganic pollutants Handbook of Polymer Nanocomposites for Industrial Applications Tabesh, F. 2021
  • Microwave-assisted synthesis of chiral polymeric materials: Properties and applications Green Sustainable Process for Chemical and Environmental Engineering and Science Tabesh, F. 2020
  • Tragacanth gum based hydrogel nanocomposites for the adsorption of methylene blue: Comparison of linear and non-linear forms of different adsorption isotherm and kinetics models. International journal of biological macromolecules Mallakpour, S., Tabesh, F. 2019; 133: 754-766

    Abstract

    In the current work, novel eco-friendly hydrogel nanocomposite biosorbents (ef-HNCs) made up from tragacanth gum and modified CaCO3 nanoparticles (CC NPs) were applied for the adsorption of methylene blue dye (MBD). A simple, fast, and safe method regarding green chemistry was used to prepare the ef-HNC, with the aid of ultrasound waves. The ef-HNCs were successfully characterized using several spectroscopic, microscopic, and analytical methods. The results of the adsorption showed that the surface modification of CC NPs has a great impact on the adsorption and increased it and showed this process is more compatible with linear pseudo-first-order kinetic and linear Langmuir isotherm models. Also, thermodynamic parameters showed that the adsorption is spontaneous, although with an increase in temperature the adsorption decreased. Also, the value of the enthalpy and Gibb's free energy showed physiochemical adsorption. The maximum adsorption capacity calculated from linear Langmuir models as 468.62 mg/g, which is an appropriate value for the natural polymer. Furthermore, phenomenological methods displayed that the film diffusion is the predominant mechanism of this adsorption process.

    View details for DOI 10.1016/j.ijbiomac.2019.04.129

    View details for PubMedID 31004645

  • Fabrication Technologies of Layered Double Hydroxide Polymer Nanocomposites Layered Double Hydroxide Polymer Nanocomposites Tabesh, F. 2019
  • Ultrasonic-assisted manufacturing of new hydrogel nanocomposite biosorbent containing calcium carbonate nanoparticles and tragacanth gum for removal of heavy metal. Ultrasonics sonochemistry Mallakpour, S., Abdolmaleki, A., Tabesh, F. 2018; 41: 572-581

    Abstract

    This article reports the first incorporation of calcium carbonate nanoparticles (CC NPs) into tragacanth gum (TG) to prepare a new hydrogel nanocomposite (HNC) system using a green, safe, and eco-friendly method, ultrasound irradiation as an efficient biosorbent of heavy metal ions from wastewater. Morphological studies revealed that the surface of obtained HNCs is rough, homogeneous, and porous-like due to the embedding of CC NPs as well as sonication in comparison to the neat TG which has a smooth surface. The particle size reduction was observed for CC NPs in the matrix (from 57 to 10 nm), which is owing to the extraordinary effect of sonication on this process. Thermal stability of HNCs has been increased after using CC NPs from 8.5 wt% for TG to about 22 wt% for HNCs. The optical band gap of TG/CC HNC 5 wt% calculated to be 4.46 eV which is less than that of CC NPs (5.58 eV) and even TG (6.28 eV) and this result indicated that TG/CC HNC 5 wt% is relatively more conductive than CC NPs and TG. The nitrogen adsorption-desorption disclosed an isotherm type III of Brunauer classification for TG/CC HNC 5 wt% and the surface area has been increased from 0.7 m2.g-1 for TG to 2.3 m2.g-1 for TG/CC HNC 5 wt%. Also, the BET surface area for TG/CC HNC 5 wt% calculated to be 7.8 nm which is classified into mesoporous materials. The Pb2+ ions were significantly removed from water using TG/CC HNC 5 wt% and the removal efficiency was determined as 83% at optimized conditions (pH = 5, adsorbent dosage = 0.015 g, time = 3 h, and Pb2+ concentration = 70 mg.L-1).

    View details for DOI 10.1016/j.ultsonch.2017.10.022

    View details for PubMedID 29137788