All Publications

  • Data-Driven Modeling of Normal and Pathological Oscillations in the Hippocampus MULTISCALE MODELS OF BRAIN DISORDERS Raikov, I., Soltesz, I., Cutsuridis 2019; 13: 185–92
  • Network Models of Epilepsy-Related Pathological Structural and Functional Alterations in the Dentate Gyrus REWIRING BRAIN: A COMPUTATIONAL APPROACH TO STRUCTURAL PLASTICITY IN THE ADULT BRAIN Raikov, I., Plitt, M., Soltesz, I., VanOoyen, A., ButzOstendorf, M. 2017: 485–503
  • Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. eLife Bezaire, M. J., Raikov, I., Burk, K., Vyas, D., Soltesz, I. 2016; 5


    The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.

    View details for DOI 10.7554/eLife.18566

    View details for PubMedID 28009257

    View details for PubMedCentralID PMC5313080