All Publications

  • Radiomodulation-The Final Frontier of Radiosurgery? Brain sciences Lam, F. C., Chau, E., Shi, Y., Martinez, B., Hamdan, A., Gill, J. L., Zagzoog, N., Kalra, N., Hori, Y. S., Schneider, M. B., Adler, J., Park, D. J., Chang, S. D. 2026; 16 (7)

    Abstract

    Stereotactic radiosurgery (SRS) delivers high doses of focused ionizing radiation (IR) to a defined target while sparing surrounding tissues. The delivery of focused doses of IR has proven to be an effective modality for the treatment of brain tumors, cerebrovascular lesions, and primary neuropathic pain conditions. More recently, the emerging concept of "radiomodulation" to rewire neural circuitry through the delivery of focused IR to specific neural relay centers has emerged as an alternative way to treat neurological conditions, such as essential tremor, trigeminal neuralgia, and psychiatric illnesses. In this article, we performed a scoping review of the existing data supporting the ability of focused doses of ionizing radiation to achieve modulation of neural circuits for the treatment of neurological conditions. We review the current understanding of the neurophysiological mechanisms of radiomodulation, the gaps in knowledge limiting its widespread use for in-human applications and stress the unmet need for ongoing research to rigorously prove that radiomodulation may be the "final frontier" as a non-invasive, non-pharmacological, versatile, and tunable modality for the treatment of a multitude of neurological conditions.

    View details for DOI 10.3390/brainsci16070751

    View details for PubMedID 42512525

    View details for PubMedCentralID PMC13406438

  • Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Frontiers in human neuroscience Vedam-Mai, V., Deisseroth, K., Giordano, J., Lazaro-Munoz, G., Chiong, W., Suthana, N., Langevin, J., Gill, J., Goodman, W., Provenza, N. R., Halpern, C. H., Shivacharan, R. S., Cunningham, T. N., Sheth, S. A., Pouratian, N., Scangos, K. W., Mayberg, H. S., Horn, A., Johnson, K. A., Butson, C. R., Gilron, R., de Hemptinne, C., Wilt, R., Yaroshinsky, M., Little, S., Starr, P., Worrell, G., Shirvalkar, P., Chang, E., Volkmann, J., Muthuraman, M., Groppa, S., Kuhn, A. A., Li, L., Johnson, M., Otto, K. J., Raike, R., Goetz, S., Wu, C., Silburn, P., Cheeran, B., Pathak, Y. J., Malekmohammadi, M., Gunduz, A., Wong, J. K., Cernera, S., Wagle Shukla, A., Ramirez-Zamora, A., Deeb, W., Patterson, A., Foote, K. D., Okun, M. S. 2021; 15: 644593

    Abstract

    We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer's disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank.

    View details for DOI 10.3389/fnhum.2021.644593

    View details for PubMedID 33953663

  • Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Frontiers in human neuroscience Vedam-Mai, V., Deisseroth, K., Giordano, J., Lazaro-Munoz, G., Chiong, W., Suthana, N., Langevin, J., Gill, J., Goodman, W., Provenza, N. R., Halpern, C. H., Shivacharan, R. S., Cunningham, T. N., Sheth, S. A., Pouratian, N., Scangos, K. W., Mayberg, H. S., Horn, A., Johnson, K. A., Butson, C. R., Gilron, R., de Hemptinne, C., Wilt, R., Yaroshinsky, M., Little, S., Starr, P., Worrell, G., Shirvalkar, P., Chang, E., Volkmann, J., Muthuraman, M., Groppa, S., Kuhn, A. A., Li, L., Johnson, M., Otto, K. J., Raike, R., Goetz, S., Wu, C., Silburn, P., Cheeran, B., Pathak, Y. J., Malekmohammadi, M., Gunduz, A., Wong, J. K., Cernera, S., Hu, W., Wagle Shukla, A., Ramirez-Zamora, A., Deeb, W., Patterson, A., Foote, K. D., Okun, M. S. 2021; 15: 765150

    Abstract

    [This corrects the article DOI: 10.3389/fnhum.2021.644593.].

    View details for DOI 10.3389/fnhum.2021.765150

    View details for PubMedID 34658825