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  • Identifying Neurophysiological Markers of Intermittent Theta-Burst Stimulation in Treatment-Resistant Depression using Transcranial Magnetic Stimulation- Electroencephalography. Biological psychiatry Strafella, R., Momi, D., Zomorrodi, R., Lissemore, J., Noda, Y., Chen, R., Rajji, T. K., Griffiths, J. D., Vila-Rodriguez, F., Downar, J., Daskalakis, Z. J., Blumberger, D. M., Voineskos, D. 2023

    Abstract

    Intermittent theta-burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (L-DLPFC) is effective for treatment-resistant depression (TRD), but iTBS' effects on neurophysiological markers remains unclear. Here, we indexed transcranial magnetic stimulation-electroencephalography (TMS-EEG) markers, specifically, the N45 and N100 amplitudes, at baseline and post-iTBS, comparing separated and contiguous iTBS schedules. TMS-EEG markers were also compared between iTBS responders and non-responders.TMS-EEG was analyzed from a triple-blind 1:1 randomized trial for TRD, comparing a separated (54 min interval) and contiguous (0 min interval) schedule of 2x600 pulse iTBS for 30 treatments. Participants underwent TMS-EEG over the L-DLPFC at baseline and post-treatment. 114 participants had usable TMS-EEG at baseline, and 98 at post-treatment. TMS-evoked potential (TEP) components (N45, N100) were examined via global mean-field analysis.The N100 amplitude decreased from baseline to post-treatment regardless of treatment group (F(1, 106) = 5.20, p = 0.02). There were no changes in N45 amplitude in either treatment group. In responders, the N100 amplitude decreased after iTBS (F(1,102) = 11.30, p = 0.001, pcorrected= 0.0004). Responders showed higher post-treatment N45 amplitude than non-responders (F(1, 94) = 4.11, p = 0.045, pcorrected= 0.016). Higher baseline N100 amplitude predicted lower post-iTBS depression scores (F(4, 106) = 6.28, p = 0.00014).These results further the evidence for an association between neurophysiological effects of iTBS and treatment efficacy in TRD. Future studies are needed to test the predictive potential for clinical applications of TMS-EEG markers.

    View details for DOI 10.1016/j.biopsych.2023.04.011

    View details for PubMedID 37084864

  • Lather, Rinse, Repeat? Breaking Repetitive Behaviors With Repetitive Stimulation. The American journal of psychiatry Lissemore, J. I., Williams, N. R. 2021; 178 (5): 378–80

    View details for DOI 10.1176/appi.ajp.2020.21030265

    View details for PubMedID 33979540