Contact

  • Academic
    jlam32@stanford.edu
    University - Student Department: East Asian Studies Position: Graduate

All Publications

  • Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans medRxiv - The preprint server for health sciences Russ-Silsby*, J., Lee*, Y., Rajesh, V., Amoli, M., Mirhosseini, N. A., Godbole, T., Johnson, M. B., Ibarra, D. E., Sun, H., Krentz, N. A., Wakeling, M. N., Flanagan, S. E., Hattersley, A. T., Gloyn, A. L., De Franco, E. 2025

    View details for DOI 10.1101/2025.04.01.25324926

  • Experience With Vertical Sleeve Gastrectomy in Adolescent and Young Adult Ehlers-Danlos Syndrome Patients: a Case Series and Review of the Literature Obesity Surgery Herdes, R. E., Abu El Haija, M., Johnson, K., Shepard, W., Zak, Y., Bruzoni, M., Pratt, J. S. 2021

    View details for DOI 10.1007/s11695-021-05453-3

  • Characteristics of Patients With Complex Limb Pain Evaluated Through an Interdisciplinary Approach Utilizing Magnetic Resonance Neurography Frontiers in Pain Research Johnson, E. M., Yoon, D., Biswal, S., Curtin, C., Fox, P., Wilson, T. J., Carroll, I., Lutz, A., Tawfik, V. 2021

    View details for DOI 10.3389/fpain.2021.689402

  • The Death of George Floyd: Bending the Arc of History Towards Justice for Generations of Children Pediatrics Dreyer, B., Trent, M., et. al. 2020

    View details for DOI 10.1542/peds.2020-009639

  • Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity Nature Immunology Liu, Q., Johnson, E., et al 2019

    View details for DOI 10.1038/s41590-019-0421-2

  • Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism. Hegarty, J. P., Zamzow, R. M., Ferguson, B. J., Christ, S. E., Porges, E. C., Johnson, J. D., Beversdorf, D. Q. 2019

    View details for DOI 10.1177/1362361319868633

  • PD-1 blockade with cemiplimab in advanced squamous cell carcinoma New England Journal of Medicine Migden, M. R., Rischin, D., Schmults, C. D., Guminski, A., Hauschild, A., Lewis, K., Chung, C. H., Hernandez-Aya, L., Lim, A., Chang, A. S., et al 2018

    View details for DOI 10.1056/NEJMoa1805131

  • Advancing Transcranial Magnetic Stimulation Methods for Complex Regional Pain Syndrome: An Open-Label Study of Paired Theta Burst and High-Frequency Stimulation Neuromodulation Gaertner, M., Kong, J., Scherrer, K., Foote, A., Mackey, S., Johnson, K. 2018

    View details for DOI 10.1111/ner.12760

  • PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke JoVE Chaney, A., Johnson, E. M., Cropper, H. C., James, M. L. 2018

    View details for DOI 10.3791/57243

  • Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly Cell Su, Z., et al 2018; 172 (5): 966-978

    Abstract

    Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular insights into the NC assembly process are lacking. Using a hybrid approach, we characterized the NC-like assembly of eNP, identified novel regulatory elements, and described how these elements impact function. We generated a three-dimensional structure of the eNP NC-like assembly at 5.8 Å using electron cryo-microscopy and identified a new regulatory role for eNP helices α22-α23. Biochemical, biophysical, and mutational analyses revealed that inter-eNP contacts within α22-α23 are critical for viral NC assembly and regulate viral RNA synthesis. These observations suggest that the N terminus and α22-α23 of eNP function as context-dependent regulatory modules (CDRMs). Our current study provides a framework for a structural mechanism for NC-like assembly and a new therapeutic target.

    View details for DOI 10.1016/j.cell.2018.02.009

    View details for PubMedCentralID PMC5973842

  • The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding Molecular Cell Zhou, C. Y., Johnson, S. L., Lee, L. J., Longhurst, A. D., Beckwith, S. L., Johnson, M. J., Morrison, A. J., Narlikar, G. J. 2018: 677–88.e9

    Abstract

    The yeast INO80 chromatin remodeling complex plays essential roles in regulating DNA damage repair, replication, and promoter architecture. INO80's role in these processes is likely related to its ability to slide nucleosomes, but the underlying mechanism is poorly understood. Here we use ensemble and single-molecule enzymology to study INO80-catalyzed nucleosome sliding. We find that the rate of nucleosome sliding by INO80 increases ∼100-fold when the flanking DNA length is increased from 40 to 60 bp. Furthermore, once sliding is initiated, INO80 moves the nucleosome rapidly at least 20 bp without pausing to re-assess flanking DNA length, and it can change the direction of nucleosome sliding without dissociation. Finally, we show that the Nhp10 module of INO80 plays an auto-inhibitory role, tuning INO80's switch-like response to flanking DNA. Our results indicate that INO80 is a highly processive remodeling motor that is tightly regulated by both substrate cues and non-catalytic subunits.

    View details for DOI 10.1016/j.molcel.2018.01.028

    View details for PubMedCentralID PMC5897057

  • Measuring canopy loss and climatic thresholds from an extreme drought along a 5-fold precipitation gradient across Texas Global Change Biology Schwantes, A. M., Swenson, J. J., González-Roglich, M., Johnson, D. M., Domec, J. C., Jackson, R. B. 2017; 23: 5120–5135

    Abstract

    Globally, trees are increasingly dying from extreme drought, a trend that is expected to increase with climate change. Loss of trees has significant ecological, biophysical, and biogeochemical consequences. In 2011, a record drought caused widespread tree mortality in Texas. Using remotely sensed imagery, we quantified canopy loss during and after the drought across the state at 30-m spatial resolution, from the eastern pine/hardwood forests to the western shrublands, a region that includes the boundaries of many species ranges. Canopy loss observations in ~200 multitemporal fine-scale orthophotos (1-m) were used to train coarser Landsat imagery (30-m) to create 30-m binary statewide canopy loss maps. We found that canopy loss occurred across all major ecoregions of Texas, with an average loss of 9.5%. The drought had the highest impact in post oak woodlands, pinyon-juniper shrublands and Ashe juniper woodlands. Focusing on a 100-km by ~1,000-km transect spanning the State's fivefold east-west precipitation gradient (~1,500 to ~300 mm), we compared spatially explicit 2011 climatic anomalies to our canopy loss maps. Much of the canopy loss occurred in areas that passed specific climatic thresholds: warm season anomalies in mean temperature (+1.6°C) and vapor pressure deficit (VPD, +0.66 kPa), annual percent deviation in precipitation (-38%), and 2011 difference between precipitation and potential evapotranspiration (-1,206 mm). Although similarly low precipitation occurred during the landmark 1950s drought, the VPD and temperature anomalies observed in 2011 were even greater. Furthermore, future climate data under the representative concentration pathway 8.5 trajectory project that average values will surpass the 2011 VPD anomaly during the 2070-2099 period and the temperature anomaly during the 2040-2099 period. Identifying vulnerable ecological systems to drought stress and climate thresholds associated with canopy loss will aid in predicting how forests will respond to a changing climate and how ecological landscapes will change in the near term.

    View details for DOI 10.1111/gcb.13775

  • Pain Catastrophizing Mediates the Relationship Between Trait Happiness and Depressive Symptoms in Individuals with Current Pain. J Appl Behav Res Tran, P., Sturgeon, J., Nilakantan, A., Foote, A., Mackey, S., Johnson, K. 2017

    View details for DOI 10.1111/jabr.12069

  • Daily Actigraphy Profiles Distinguish Depressive and Interepisode States in Bipolar Disorder Clinical Psychological Science Gershon, A., Ram, N., Johnson, S. L., Harvey, A. G., Zeitzer, J. M. 2016; 4 (4): 641– 650

    Abstract

    Disruptions in activity are core features of mood states in bipolar disorder (BD). This study sought to identify activity patterns that discriminate between mood states in BD. Locomotor activity was collected using actigraphy for six weeks in participants with inter-episode BD type I (n=37) or participants with no lifetime mood disorders (n=39). The 24-hour activity pattern of each participant-day was characterized and within-person differences in activity patterns were examined across mood states. Results show that among participants with BD, depressive days are distinguished from other mood states by an overall lower activity level, and a pattern of later activity onset, a midday elevation of activity, and low evening activity. No distinct within-person activity patterns were found for hypomanic/manic days. Since activity can be monitored non-invasively for extended time periods, activity pattern identification may be leveraged to detect mood states in BD, thereby providing more immediate delivery of care.

    View details for DOI 10.1177/2167702615604613

    View details for PubMedCentralID PMC5022043

  • Triglyceride Levels and Fracture Risk in Midlife Women: Study of Women's Health Across the Nation Journal of Clinical Endocrinology and Metabolism Chang, P., Gold, E. B., Cauley, J., Johnson, W. O., Karvonen-Guitierrez, C., Jackson, E., Ruppert, K., Lee, J. S. 2016: 3297–3305

    Abstract

    Unfavorable lipid levels contribute to cardiovascular disease and may also harm bone health.Our objective was to investigate relationships between fasting plasma lipid levels and incident fracture in midlife women undergoing the menopausal transition.This was a 13-year prospective, longitudinal study of multiethnic women in five US communities, with near-annual assessments.At baseline, 2062 premenopausal or early perimenopausal women who had no history of fracture were included.Fasting plasma total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol at baseline and follow-up visits 1 and 3-7.Incident nontraumatic fractures 1) 2 or more years after baseline, in relation to a single baseline level of lipids; and 2) 2-5 years later, in relation to time-varying lipid levels. Cox proportional hazards modelings estimated hazard ratios and 95% confidence interval (CI).Among the lipids, TG levels changed the most, with median levels increased by 16% during follow-up. An increase of 50 mg/dl in baseline TG level was associated with a 1.1-fold increased hazards of fracture (adjusted hazard ratio, 1.11; 95% CI, 1.04-1.18). Women with baseline TG higher than 300 mg/dl had an adjusted 2.5-fold greater hazards for fractures (95% CI, 1.13-5.44) than women with baseline TG lower than 150 mg/dl. Time-varying analyses showed a comparable TG level-fracture risk relationship. Associations between total cholesterol, low-density lipoprotein cholesterol, or high-density lipoprotein cholesterol levels and fractures were not observed.Midlife women with high fasting plasma TG had an increased risk of incident nontraumatic fracture. Secondary Abstract: Midlife women with fasting plasma triglyceride (TG) of at least 300 mg/dl had 2.5-fold greater hazards of fracture in 2 years later and onward, compared to those with TG below 150 mg/dl, in a multiethnic cohort. Time-varying analyses revealed comparable results.

    View details for DOI 10.1210/jc.2016-1366

    View details for PubMedCentralID PMC5010577