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  • Stress response silencing by an E3 ligase mutated in neurodegeneration. Nature Haakonsen, D. L., Heider, M., Ingersoll, A. J., Vodehnal, K., Witus, S. R., Uenaka, T., Wernig, M., Rap√©, M. 2024


    Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts organismal health1-3. How stress responses are turned off at the right time and place remains poorly understood. Here we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress. Crucial to this process is the silencing factor of the integrated stress response (SIFI), a large E3 ligase complex mutated in ataxia and in early-onset dementia that degrades both unimported mitochondrial precursors and stress response components. By recognizing bifunctional substrate motifs that equally encode protein localization and stability, the SIFI complex turns off a general stress response after a specific stress event has been resolved. Pharmacological stress response silencing sustains cell survival even if stress resolution failed, which underscores the importance of signal termination and provides a roadmap for treating neurodegenerative diseases caused by mitochondrial import defects.

    View details for DOI 10.1038/s41586-023-06985-7

    View details for PubMedID 38297121

    View details for PubMedCentralID 8997189