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  • Mail Code: 4245

All Publications

  • BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes. Neuroinformatics Athey, T. L., Wright, M. A., Pavlovic, M., Chandrashekhar, V., Deisseroth, K., Miller, M. I., Vogelstein, J. T. 2023

    View details for DOI 10.1007/s12021-023-09638-2

    View details for PubMedID 37394568

  • BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes. bioRxiv : the preprint server for biology Athey, T. L., Wright, M. A., Pavlovic, M., Chandrashekhar, V., Deisseroth, K., Miller, M. I., Vogelstein, J. T. 2023

    Abstract

    Whole-brain fluorescence images require several stages of computational processing to fully reveal the neuron morphology and connectivity information they contain. However, these computational tools are rarely part of an integrated pipeline. Here we present BrainLine, an open-source pipeline that interfaces with existing software to provide registration, axon segmentation, soma detection, visualization and analysis of results. By implementing a feedback based training paradigm with BrainLine, we were able to use a single learning algorithm to accurately process a diverse set of whole-brain images generated by light-sheet microscopy. BrainLine is available as part of our Python package brainlit: http://brainlit.neurodata.io/ .

    View details for DOI 10.1101/2023.02.28.530429

    View details for PubMedID 36909631

    View details for PubMedCentralID PMC10002688