Bio


Dr. Yunce is board certified in internal medicine and transfusion medicine. He joined Stanford Health Care as a clinical fellow and completed his fellowship in July 2019. He has keen interest in patient blood management and applications of therapeutic apheresis in various disease processes.

Clinical Focus


  • Blood Banking/Transfusion Medicine
  • Therapeutic Apheresis
  • Internal Medicine

Academic Appointments


  • Clinical Assistant Professor, Pathology

Administrative Appointments


  • Medical Director, Therapeutic Apheresis, Stanford University Medical Center (2021 - Present)

Honors & Awards


  • Charles B. Carrington Outstanding Poster Presentation Award, Stanford University (2018)
  • Member, Alpha Omega Alpha Medical Honor Society, Stanford University (2019)

Professional Education


  • Board Certification: American Board of Pathology, Blood Banking/Transfusion Medicine (2019)
  • Fellowship: Stanford University Pathology Fellowships (2019) CA
  • Board Certification: American Board of Internal Medicine, Internal Medicine (2018)
  • Residency: Medstar Georgetown University Hospital (2018) DC
  • Medical Education: Dicle University School of Medicine (2010) Turkey

All Publications


  • Plasma exchange for severe immune-related adverse events from checkpoint inhibitors: an early window of opportunity? Immunotherapy advances Katsumoto, T. R., Wilson, K. L., Giri, V. K., Zhu, H., Anand, S., Ramchandran, K. J., Martin, B. A., Yunce, M., Muppidi, S. 2022; 2 (1): ltac012

    Abstract

    Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of several advanced malignancies leading to durable remission in a subset of patients. Their rapidly expanding use has led to an increased frequency of immune-related adverse events (irAEs). The pathogenesis of irAEs is poorly understood but may involve aberrant activation of T cells leading to inflammatory cytokine release or production of pathogenic antibodies leading to organ damage. Severe irAEs can be extremely debilitating and, in some cases, life threatening. IrAEs may not always be corticosteroid responsive or may require excessively high, often toxic, corticosteroid doses. Therapeutic plasma exchange (PLEX) is a treatment modality that has shown promising results for the management of certain severe irAEs, including irAEs that are not mentioned in current treatment guidelines. PLEX may attenuate ongoing irAEs and prevent delayed irAEs by accelerating clearance of the ICI, or by acutely removing pathogenic antibodies, cytokines, and chemokines. Here, we summarize examples from the literature in which PLEX was successfully used for the treatment of irAEs. We posit that timing may be a critical factor and that earlier utilization of PLEX for life-threatening irAEs may result in more favorable outcomes. In individuals at high risk for irAEs, the availability of PLEX as a potential therapeutic mitigation strategy may encourage life-saving ICI use or rechallenge. Future research will be critical to better define which indications are most amenable to PLEX, particularly to establish the optimal place in the sequence of irAE therapies and to assess the ramifications of ICI removal on cancer outcomes.

    View details for DOI 10.1093/immadv/ltac012

    View details for PubMedID 35814850

    View details for PubMedCentralID PMC9257781

  • Non-HLA Antibody-Mediated Rejection of Lung Transplant Masquerading Transfusion-Related Acute Lung Injury Yunce, M., Virk, M., Zhang, B. M., Mooney, K., Saleem, A., Shan, H. WILEY. 2019: 199A
  • Reducing Length of Stay and Red Blood Cell Transfusion by Implementing an Anesthesia Anemia Management Clinic Yunce, M., Shan, H., Tho Pham, Panigrahi, A. WILEY. 2019: 208A
  • Reducing Length of Stay and Red Blood Cell Transfusion by Implementing an Anesthesia Anemia Management Clinic Yunce, M., Tho Pham, Panigrahi, A. LIPPINCOTT WILLIAMS & WILKINS. 2019: 10