How Should US Health Care Lead Global Change in Plastic Waste Disposal?
AMA journal of ethics
2022; 24 (10): E986-993
Disposal of health care waste is one of the biggest threats to global sustainable health care. Current practices of dumping domestic and international health care waste into the earth's terra firma and oceans also undermine global health equity by adversely affecting the health of vulnerable communities. While the United Kingdom works toward circular health care economy streams that produce minimal waste, the United States continues to amplify downstream environmental and health effects of health care organizational waste management decisions. This article suggests how to reframe social and ethical responsibility for health care waste production and management by assigning strict accountability to health care organizational leaders, incentivizing circular supply chain implementation and maintenance, and encouraging strong collaborations across medical, plastic, and waste industries.
View details for DOI 10.1001/amajethics.2022.986
View details for PubMedID 36215191
Tipping cancer cells over the edge: the context-dependent cost of high ploidy.
Tetraploidy is an aneuploidy-permissive condition that can fuel tumorgenesis. The tip-over hypothesis of cytotoxic therapy-sensitivity proposes that therapy is eﬀective if it pushes a cell's aneuploidy above a viable tipping point. But elevated aneuploidy alone may not account for this tipping point. Tissue micro-environments (TMEs) that lack sufficient resources to support tetraploid cells can explain the fitness cost of aneuploidy. Raw materials needed to generate deoxynucleotides, the building blocks of DNA, are candidate rate-limiting factors for the evolution of high-ploidy cancer cells. Understanding the resource cost of high ploidy is key to uncover its therapeutic vulnerabilities across tissue sites with versatile energy supplies.
View details for DOI 10.1158/0008-5472.CAN-21-2794
View details for PubMedID 34785577
COVID-19 Solutions Are Climate Solutions: Lessons From Reusable Gowns
Frontiers in Public Health
View details for DOI 10.3389/fpubh.2020.590275