Neeraj Kalra

All Publications

• Outcome of CyberKnife stereotactic radiosurgery for the brain metastases in patients with Li Fraumeni syndrome. Journal of neuro-oncology Izhar, M., Hori, Y. S., Kattaa, A. H., Harary, P. M., Lam, F. C., Kalra, N., Zagzoog, N., Tayag, A., Ustrzynski, L., Emrich, S. C., Park, D. J., Chang, S. D. 2026; 178 (1)

  Abstract

  Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome associated with germline TP53 mutations and an increased risk of radiation-induced malignancies, posing significant challenges in the management of brain metastases (BM). Data regarding the safety and efficacy of stereotactic radiosurgery (SRS) for BM in this population remain limited.We performed a retrospective analysis of patients with LFS who underwent SRS for BM at our institution. Patient-level, lesion-level, and treatment-related data were collected. Outcomes assessed included local tumor control (LTC), overall survival (OS), distant progression-free survival (DPFS), radiographic response, and treatment-related adverse events.A total of 5 patients with 16 BM lesions were treated with SRS. The median age at treatment was 49 years (range, 37-65). Lesions were typically small (median diameter 6.1 mm) and predominantly supratentorial (87.5%). Most lesions (93.7%) were treated with single-fraction SRS with a median prescribed dose of 24 Gy. LTC was 100% at 3 months, 6 months, and the last follow-up. Median OS and DPFS were 11.03 months (95% CI, 9.53-12.54) and 7.5 months (95% CI, 7.3-7.7), with all deaths attributable to systemic disease rather than neurological causes. Importantly, no cases of radiation necrosis or radiation-induced secondary malignancies were observed during a median follow-up of 45 weeks.SRS demonstrated a short-term favorable local control and safety profile for the treatment of BM in patients with LFS. Given the tendency for lesions to be small and multifocal, along with the need to minimize radiation exposure, SRS represents a rational, focal treatment approach in this high-risk population. However, longer follow-up and prospective studies are needed to better define long-term safety, particularly regarding the risk of radiation-induced malignancies.Not applicable.

  View details for DOI 10.1007/s11060-026-05610-7

  View details for PubMedID 42149268

  View details for PubMedCentralID 1858532

• The impact of CHEK2 status on radiosurgical outcomes in breast cancer brain metastases. Neurosurgical review Harary, P. M., Hori, Y. S., Kattaa, A. H., Tan, S. K., Lam, F. C., Kalra, N., Zagzoog, N., Tayag, A., Ustrzynski, L., Emrich, S. C., Gibbs, I. C., Li, G., Kuno, A., Park, D. J., Chang, S. D. 2026; 49 (1)

  View details for DOI 10.1007/s10143-026-04272-3

  View details for PubMedID 41963546

  View details for PubMedCentralID 3698070

• Treatment outcomes of stereotactic radiosurgery for sarcoma brain metastases-systematic review. Journal of neuro-oncology Izhar, M., Kattaa, A. H., Hori, Y. S., Lam, F. C., Kalra, N., Zagzoog, N., Tayag, A., Ustrzynski, L., Emrich, S. C., Park, D. J., Chang, S. D. 2026; 177 (2)

  View details for DOI 10.1007/s11060-026-05542-2

  View details for PubMedID 41872576

  View details for PubMedCentralID 10725339

• Treatment outcomes of cerebral arteriovenous malformations in patients with Hereditary hemorrhagic Telangiectasia: A case series from a Single-Center experience. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Izhar, M., Al Gharyani, M. F., Hori, Y. S., Kattaa, A. H., Lam, F. C., Kalra, N., Zagzoog, N., Tayag, A., Ustrzynski, L., Emrich, S. C., Park, D. J., Chang, S. D. 2025; 143: 111750

  Abstract

  Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant vascular disorder characterized by multisystemic arteriovenous malformations (AVMs), including those in the central nervous system. Cerebral AVMs (cAVM), present in up to 23% of patients with HHT, pose a risk of serious neurological complications such as hemorrhage or seizures. Despite their clinical significance, standardized treatment guidelines for cAVM in HHT remain lacking due to limited data. This study evaluates outcomes of stereotactic radiosurgery (SRS) and microsurgical resection for unruptured cAVM in patients with HHT.We retrospectively analyzed 26 patients with clinically or genetically confirmed HHT and radiologically verified unruptured cAVM treated at our institution between 1996 and 2024. Patients were selected based on treatment with either surgery or SRS and a minimum of 1-year follow-up, excluding cases with prior ruptures or previous AVM interventions. Clinical, radiographic, and treatment data were collected and reviewed, including AVM characteristics, intervention parameters, and functional outcomes. The outcomes were changes in functional status measured by the modified Rankin Scale (mRS), complication rates, AVM obliteration, and recurrence. Statistical analysis included the X2 test, Fisher's exact test, and the Mann-Whitney U test, with significance set at p < 0.05. Survival outcomes were assessed using Kaplan-Meier analysis.Among 26 patients, 4 underwent CyberKnife SRS and 22 had microsurgical resection. In the SRS group, all patients were female with a mean age of 39 years at the time of diagnosis; 80 % of lesions achieved complete obliteration at a median follow-up of 5.9 years. Most lesions were superficial, small in volume (mean: 0.16 cm3), and received an average marginal dose of 20.1 Gy. Post-radiosurgical complications occurred in 50 %, primarily headaches and visual disturbances; no hemorrhages or seizures were reported. In the surgery group, 92 % of lesions were obliterated with a median follow-up of 2.75 years. Functional status remained stable or improved in 68 % of patients, with a significant change between pre- and postoperative scores (P = 0.03). Postoperative complications occurred in 23 % of patients, and AVM recurrence was significantly associated with SM grade (P = 0.005). No mortality was observed in either group.In patients with HHT, cAVMs are typically small, multiple, and low-grade with a low risk of hemorrhage. Both surgical resection and SRS are effective treatment options, though further prospective studies are needed to better define and compare their long-term outcomes.

  View details for DOI 10.1016/j.jocn.2025.111750

  View details for PubMedID 41237734

• Stereotactic radiosurgery for hepatitis C virus-related hepatocellular carcinoma brain metastasis: A retrospective analysis and systematic review WORLD NEUROSURGERY-X Izhar, M., Hori, Y. S., Kattaa, A. H., Lam, F. C., Kalra, N., Zagzoog, N., Tayag, A., Ustrzynski, L., Emrich, S. C., Pollom, E. L., Soltys, S. G., Gephart, M., Park, D. J., Chang, S. D. 2025; 28

  View details for DOI 10.1016/j.wnsx.2025.100541

  View details for Web of Science ID 001602623500001