I am board-certified internal medicine and clinical informatics. I am a primary care physician and teaching hospitalist. I have published work in the New England Journal of Medicine, Health Affairs, Annals of Internal Medicine, and the Journal of the American Medical Informatics Association. My primary focus throughout my career has been to deliver personalized and compassionate care that incorporates the latest advancements in medical science. I aim to help all of my patients maximize their healthspan and age with the best quality of life possible.

Clinical Focus

  • Internal Medicine
  • Primary Care

Academic Appointments

Administrative Appointments

  • Medical Informatics Director, Stanford Health Care (2017 - 2019)
  • Program Director, Partnership in AI-assisted Care (PAC, Clinical Effectiveness Research Center (CERC) (2017 - 2020)

Professional Education

  • Fellowship: Stanford Hospitals and Clinics (2016) CA
  • Residency: Stanford University Internal Medicine Residency (2014) CA
  • Board Certification: American Board of Preventive Medicine, Clinical Informatics (2017)
  • Medical Education: Case Western Reserve School of Medicine (2011) OH
  • Board Certification: American Board of Internal Medicine, Internal Medicine (2014)

Clinical Trials

  • Study of an Electronic Health Record-embedded Severe Sepsis Early Warning Alert Not Recruiting

    The investigators hypothesize that implementing an electronic health record-based early warning system for severe infections (severe sepsis) will decrease the time to antibiotic order. The study will consist of an algorithm which will monitor lab values, vital signs, and nursing documentation for signs of severe sepsis. When these criteria are met, an alert will be delivered via the electronic health record to a nurse and doctor and simultaneously an alert via pager to another nurse. The investigators plan to randomize which patients will generate these alerts and analyze the data after collecting information for approximately 6 months which will be sufficient to detect a 10% difference in the two patient groups.

    Stanford is currently not accepting patients for this trial.

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  • Virtual Hypertension Management Pilot Not Recruiting

    Investigators are examining the quality improvement impact of providing patients with a an electronic health record-connected blood pressure cuff. Investigators will give half of patients already eligible for hypertension management within a clinical pharmacist panel, the ability to upload their blood pressure data into Stanford's electronic health record.

    Stanford is currently not accepting patients for this trial. For more information, please contact Norman Downing, MD, 650-723-6000.

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2023-24 Courses

Graduate and Fellowship Programs

All Publications

  • User-centred design for machine learning in health care: a case study from care management. BMJ health & care informatics Seneviratne, M. G., Li, R. C., Schreier, M., Lopez-Martinez, D., Patel, B. S., Yakubovich, A., Kemp, J. B., Loreaux, E., Gamble, P., El-Khoury, K., Vardoulakis, L., Wong, D., Desai, J., Chen, J. H., Morse, K. E., Downing, N. L., Finger, L. T., Chen, M., Shah, N. 2022; 29 (1)


    OBJECTIVES: Few machine learning (ML) models are successfully deployed in clinical practice. One of the common pitfalls across the field is inappropriate problem formulation: designing ML to fit the data rather than to address a real-world clinical pain point.METHODS: We introduce a practical toolkit for user-centred design consisting of four questions covering: (1) solvable pain points, (2) the unique value of ML (eg, automation and augmentation), (3) the actionability pathway and (4) the model's reward function. This toolkit was implemented in a series of six participatory design workshops with care managers in an academic medical centre.RESULTS: Pain points amenable to ML solutions included outpatient risk stratification and risk factor identification. The endpoint definitions, triggering frequency and evaluation metrics of the proposed risk scoring model were directly influenced by care manager workflows and real-world constraints.CONCLUSIONS: Integrating user-centred design early in the ML life cycle is key for configuring models in a clinically actionable way. This toolkit can guide problem selection and influence choices about the technical setup of the ML problem.

    View details for DOI 10.1136/bmjhci-2022-100656

    View details for PubMedID 36220304

  • Assessing the impact of the COVID-19 pandemic on clinician ambulatory electronic health record use. Journal of the American Medical Informatics Association : JAMIA Holmgren, A. J., Downing, N. L., Tang, M., Sharp, C., Longhurst, C., Huckman, R. S. 2021


    OBJECTIVE: The COVID-19 pandemic changed clinician electronic health record (EHR) work in a multitude of ways. To evaluate how, we measure ambulatory clinician EHR use in the United States throughout the COVID-19 pandemic.MATERIALS AND METHODS: We use EHR meta-data from ambulatory care clinicians in 366 health systems using the Epic EHR system in the United States from December 2019 to December 2020. We used descriptive statistics for clinician EHR use including active-use time across clinical activities, time after-hours, and messages received. Multivariable regression to evaluate total and after-hours EHR work adjusting for daily volume and organizational characteristics, and to evaluate the association between messages and EHR time.RESULTS: Clinician time spent in the EHR per day dropped at the onset of the pandemic but had recovered to higher than prepandemic levels by July 2020. Time spent actively working in the EHR after-hours showed similar trends. These differences persisted in multivariable models. In-Basket messages received increased compared with prepandemic levels, with the largest increase coming from messages from patients, which increased to 157% of the prepandemic average. Each additional patient message was associated with a 2.32-min increase in EHR time per day (P < .001).DISCUSSION: Clinicians spent more total and after-hours time in the EHR in the latter half of 2020 compared with the prepandemic period. This was partially driven by increased time in Clinical Review and In-Basket messaging.CONCLUSIONS: Reimbursement models and workflows for the post-COVID era should account for these demands on clinician time that occur outside the traditional visit.

    View details for DOI 10.1093/jamia/ocab268

    View details for PubMedID 34888680

  • Differences in Total and After-hours Electronic Health Record Time Across Ambulatory Specialties. JAMA internal medicine Rotenstein, L. S., Holmgren, A. J., Downing, N. L., Bates, D. W. 2021

    View details for DOI 10.1001/jamainternmed.2021.0256

    View details for PubMedID 33749732

  • Technology-Enabled Consumer Engagement: Promising Practices At Four Health Care Delivery Organizations. Health affairs (Project Hope) Tai-Seale, M., Downing, N. L., Jones, V. G., Milani, R. V., Zhao, B., Clay, B., Sharp, C. D., Chan, A. S., Longhurst, C. A. 2019; 38 (3): 383–90


    Patients' journeys across the care continuum can be improved with patient-centered technology integrated into the care process. Misaligned financial incentives, change management challenges, and privacy concerns are some of the hurdles that have prevented health systems from deploying technology that engages patients along the care continuum. Despite these sociotechnical challenges, some health care organizations have developed innovative approaches to engaging patients. We describe promising technology-enabled consumer engagement practices at two community-based delivery organizations and two academic medical centers to demonstrate the approaches, sociotechnical challenges, and outcomes associated with their implementation. Leadership commitment and payer policies that align with the quadruple aim-enhancing patient experience, improving population health, reducing costs, and improving the work life of health care providers-would encourage further deployment and lead to greater consumer engagement along the care continuum.

    View details for DOI 10.1377/hlthaff.2018.05027

    View details for PubMedID 30830826

  • Improving palliative care with deep learning. BMC medical informatics and decision making Avati, A., Jung, K., Harman, S., Downing, L., Ng, A., Shah, N. H. 2018; 18 (Suppl 4): 122


    BACKGROUND: Access to palliative care is a key quality metric which most healthcare organizations strive to improve. The primary challenges to increasing palliative care access are a combination of physicians over-estimating patient prognoses, and a shortage of palliative staff in general. This, in combination with treatment inertia can result in a mismatch between patient wishes, and their actual care towards the end of life.METHODS: In this work, we address this problem, with Institutional Review Board approval, using machine learning and Electronic Health Record (EHR) data of patients. We train a Deep Neural Network model on the EHR data of patients from previous years, to predict mortality of patients within the next 3-12 month period. This prediction is used as a proxy decision for identifying patients who could benefit from palliative care.RESULTS: The EHR data of all admitted patients are evaluated every night by this algorithm, and the palliative care team is automatically notified of the list of patients with a positive prediction. In addition, we present a novel technique for decision interpretation, using which we provide explanations for the model's predictions.CONCLUSION: The automatic screening and notification saves the palliative care team the burden of time consuming chart reviews of all patients, and allows them to take a proactive approach in reaching out to such patients rather then relying on referrals from the treating physicians.

    View details for PubMedID 30537977

  • Physician Burnout in the Electronic Health Record Era: Are We Ignoring the Real Cause? ANNALS OF INTERNAL MEDICINE Downing, N., Bates, D. W., Longhurst, C. A. 2018; 169 (1): 50-+

    View details for PubMedID 29801050

  • Bedside Computer Vision - Moving Artificial Intelligence from Driver Assistance to Patient Safety. The New England journal of medicine Yeung, S. n., Downing, N. L., Fei-Fei, L. n., Milstein, A. n. 2018; 378 (14): 1271–73

    View details for PubMedID 29617592

  • Design and Implementation of an Electronic Health Record-Integrated Hypertension Management Application. Journal of the American Heart Association Funes Hernandez, M., Babakhanian, M., Chen, T. P., Sarraju, A., Seninger, C., Ravi, V., Azizi, Z., Tooley, J., Chang, T. I., Lu, Y., Downing, N. L., Rodriguez, F., Li, R. C., Sandhu, A. T., Turakhia, M., Bhalla, V., Wang, P. J. 2024; 13 (2): e030884


    High blood pressure affects approximately 116 million adults in the United States. It is the leading risk factor for death and disability across the world. Unfortunately, over the past decade, hypertension control rates have decreased across the United States. Prediction models and clinical studies have shown that reducing clinician inertia alone is sufficient to reach the target of ≥80% blood pressure control. Digital health tools containing evidence-based algorithms that are able to reduce clinician inertia are a good fit for turning the tide in blood pressure control, but careful consideration should be taken in the design process to integrate digital health interventions into the clinical workflow.We describe the development of a provider-facing hypertension management platform. We enumerate key steps of the development process, including needs finding, clinical workflow analysis, treatment algorithm creation, platform design and electronic health record integration. We interviewed and surveyed 5 Stanford clinicians from primary care, cardiology, and their clinical care team members (including nurses, advanced practice providers, medical assistants) to identify needs and break down the steps of clinician workflow analysis. The application design and development stage were aided by a team of approximately 15 specialists in the fields of primary care, hypertension, bioinformatics, and software development.Digital monitoring holds immense potential for revolutionizing chronic disease management. Our team developed a hypertension management platform at an academic medical center to address some of the top barriers to adoption and achieving clinical outcomes. The frameworks and processes described in this article may be used for the development of a diverse range of digital health tools in the cardiovascular space.

    View details for DOI 10.1161/JAHA.123.030884

    View details for PubMedID 38226516

  • Hepatitis C Screening in Post-Baby Boomer Generation Americans: One Size Does Not Fit All. Mayo Clinic proceedings Sripongpun, P., Udompap, P., Mannalithara, A., Downing, N. L., Vidovszky, A. A., Kwong, A. J., Goel, A., Kwo, P. Y., Kim, W. R. 2023; 98 (9): 1335-1344


    To analyze the impact of access to routine health care, as estimated by health insurance coverage, on hepatitis C virus (HCV) infection prevalence in US adults born after 1965 (post-baby boomer birth cohort [post-BBBC]) and to use the data to formulate strategies to optimize population screening for HCV.Adult examinees in the National Health and Nutrition Examination Survey with available anti-HCV data were divided into era 1 (1999-2008) and era 2 (2009-2016). The prevalence of HCV infection, as defined by detectable serum HCV RNA, was determined in post-BBBC adults. In low prevalence groups, prescreening modalities were considered to increase the pretest probability.Of 16,966 eligible post-BBBC examinees, 0.5% had HCV infection. In both eras, more than 50% had no insurance. In era 2, HCV prevalence was 0.26% and 0.83% in those with and without insurance, respectively (P<.01). As a prescreening test, low alanine aminotransferase level (<23 U/L in women and 32 U/L in men) would identify 54% of post-BBBC adults with an extremely low (0.02%) HCV prevalence. Based on these data, a tiered approach that tests all uninsured directly for HCV and prescreens the insured with alanine aminotransferase would reduce the number to test by 56.5 million while missing less than 1% infections.For HCV elimination, passive "universal" screening in routine health care settings is insufficient, although the efficiency of screening may be improved with alanine aminotransferase prescreening. Importantly, for individuals with limited access to health care, proactive outreach programs for HCV screening are still needed.

    View details for DOI 10.1016/j.mayocp.2023.02.009

    View details for PubMedID 37661141

  • Association between state-level malpractice environment and clinician electronic health record (EHR) time. Journal of the American Medical Informatics Association : JAMIA Holmgren, A. J., Rotenstein, L., Downing, N. L., Bates, D. W., Schulman, K. 2022


    OBJECTIVE: Clinicians spend significant time working in the electronic health record (EHR). The US is an outlier in EHR time, suggesting that EHR-related work may be driven in part by the legal environment and threat of malpractice. To assess this, we evaluate the association between state-level malpractice climate and clinician time spent in the EHR.MATERIALS AND METHODS: We use EHR metadata from 351 ambulatory care health systems in the United States using Epic from January-August 2019 combined with state-level data on malpractice incidence and payouts. We used descriptive statistics to measure variation in clinician EHR time, including total EHR time, documentation time per day, and after-hours EHR time per day. Multi-variable regression evaluated the association between clinicians in high malpractice states and EHR use.RESULTS: We found no association between location in a state in the top-quartile of malpractice payouts and time spent in the EHR per day, time spent in the EHR outside of scheduled hours, or time spent documenting per day, except for a subgroup of the clinicians in the highest malpractice specialties, where there was a small increase in EHR time per day (B=6.08 min, P<0.001) and time spent documenting notes (B=2.77 min, P<0.001).DISCUSSION: State-level differences in malpractice incidence are unlikely to be a significant driver of EHR work for most clinicians.CONCLUSION: Policymakers seeking to address EHR documentation burden should examine burden driven by other socio-technical demands on clinician time, such as billing or quality measurement.

    View details for DOI 10.1093/jamia/ocac034

    View details for PubMedID 35271723

  • Targeted Electronic Patient Portal Messaging Increases Hepatitis C Virus Screening in Primary Care: a Randomized Study. Journal of general internal medicine Halket, D., Dang, J., Phadke, A., Jayasekera, C., Kim, W. R., Kwo, P., Downing, L., Goel, A. 2022


    IMPORTANCE: Electronic health record (EHR) tools such as direct-to-patient messaging and automated lab orders are effective at improving uptake of preventive health measures. It is unknown if patient engagement in primary care impacts efficacy of such messaging.OBJECTIVE: To determine whether more engaged patients, defined as those who have an upcoming visit scheduled, are more likely to respond to a direct-to-patient message with an automated lab order for hepatitis C virus (HCV) screening.DESIGN: Randomized trial PARTICIPANTS: One thousand six hundred randomly selected Stanford Primary Care patients, 800 with an upcoming visit within 6 months and 800 without, born between 1945 and 1965 who were due for HCV screening. Each group was randomly divided into cohorts of 400 subjects each. Subjects were followed for 1 year.INTERVENTION: One 400 subject cohort in each group received a direct-to-patient message through the EHR portal with HCV antibody lab order.MAIN OUTCOME AND MEASURE: The EHR was queried on a monthly basis for 6 months after the intervention to monitor which subjects completed HCV screening. For any subjects screened positive for HCV, follow-up through the cascade of HCV care was monitored, and if needed, scheduled by the study team.KEY RESULTS: Of 1600 subjects, 538 (34%) completed HCV screening. In the stratum without an upcoming appointment, 18% in the control group completed screening compared to 26% in intervention group (p<0.01). Similarly, in the stratum with an upcoming appointment, 34% in the control group completed screening compared to 58% in the intervention group (p<0.01).CONCLUSION: Direct-to-patient messaging coupled with automated lab orders improved HCV screening rates compared to standard of care, particularly in more engaged patients. Including this intervention in primary care can maximize screening with each visit, which is particularly valuable in times when physical throughput in the healthcare system may be low.

    View details for DOI 10.1007/s11606-022-07460-1

    View details for PubMedID 35230622

  • Differences in Clinician Electronic Health Record Use Across Adult and Pediatric Primary Care Specialties. JAMA network open Rotenstein, L. S., Holmgren, A. J., Downing, N. L., Longhurst, C. A., Bates, D. W. 2021; 4 (7): e2116375

    View details for DOI 10.1001/jamanetworkopen.2021.16375

    View details for PubMedID 34241631

  • Assessment of Electronic Health Record Use Between US and Non-US Health Systems. JAMA internal medicine Holmgren, A. J., Downing, N. L., Bates, D. W., Shanafelt, T. D., Milstein, A., Sharp, C. D., Cutler, D. M., Huckman, R. S., Schulman, K. A. 2020


    Importance: Understanding how the electronic health record (EHR) system changes clinician work, productivity, and well-being is critical. Little is known regarding global variation in patterns of use.Objective: To provide insights into which EHR activities clinicians spend their time doing, the EHR tools they use, the system messages they receive, and the amount of time they spend using the EHR after hours.Design, Setting, and Participants: This cross-sectional study analyzed the deidentified metadata of ambulatory care health systems in the US, Canada, Northern Europe, Western Europe, the Middle East, and Oceania from January 1, 2019, to August 31, 2019. All of these organizations used the EHR software from Epic Systems and represented most of Epic Systems's ambulatory customer base. The sample included all clinicians with scheduled patient appointments, such as physicians and advanced practice practitioners.Exposures: Clinician EHR use was tracked by deidentified and aggregated metadata across a variety of clinical activities.Main Outcomes and Measures: Descriptive statistics for clinician EHR use included time spent on clinical activities, note documentation (as measured by the percentage of characters in the note generated by automated or manual data entry source), messages received, and time spent after hours.Results: A total of 371 health systems were included in the sample, of which 348 (93.8%) were located in the US and 23 (6.2%) were located in other countries. US clinicians spent more time per day actively using the EHR compared with non-US clinicians (mean time, 90.2 minutes vs 59.1 minutes; P<.001). In addition, US clinicians vs non-US clinicians spent significantly more time performing 4 clinical activities: notes (40.7 minutes vs 30.7 minutes; P<.001), orders (19.5 minutes vs 8.75 minutes; P<.001), in-basket messages (12.5 minutes vs 4.80 minutes; P<.001), and clinical review (17.6 minutes vs 14.8 minutes; P=.01). Clinicians in the US composed more automated note text than their non-US counterparts (77.5% vs 60.8% of note text; P<.001) and received statistically significantly more messages per day (33.8 vs 12.8; P<.001). Furthermore, US clinicians used the EHR for a longer time after hours, logging in 26.5 minutes per day vs 19.5 minutes per day for non-US clinicians (P=.01). The median US clinician spent as much time actively using the EHR per day (90.1 minutes) as a non-US clinician in the 99th percentile of active EHR use time per day (90.7 minutes) in the sample. These results persisted after controlling for organizational characteristics, including structure, type, size, and daily patient volume.Conclusions and Relevance: This study found that US clinicians compared with their non-US counterparts spent substantially more time actively using the EHR for a wide range of clinical activities or tasks. This finding suggests that US clinicians have a greater EHR burden that may be associated with nontechnical factors, which policy makers and health system leaders should consider when addressing clinician wellness.

    View details for DOI 10.1001/jamainternmed.2020.7071

    View details for PubMedID 33315048

  • Electronic health record-based clinical decision support alert for severe sepsis: a randomised evaluation BMJ QUALITY & SAFETY Downing, N., Rolnick, J., Poole, S. F., Hall, E., Wessels, A. J., Heidenreich, P., Shieh, L. 2019; 28 (9): 762–68
  • A crisis within an epidemic: critical opioid shortage in US hospitals. Postgraduate medical journal Wang, B., Downing, N. L. 2019

    View details for DOI 10.1136/postgradmedj-2018-136058

    View details for PubMedID 31217184

  • Electronic health record-based clinical decision support alert for severe sepsis: a randomised evaluation. BMJ quality & safety Downing, N. L., Rolnick, J., Poole, S. F., Hall, E., Wessels, A. J., Heidenreich, P., Shieh, L. 2019


    BACKGROUND: Sepsis remains the top cause of morbidity and mortality of hospitalised patients despite concerted efforts. Clinical decision support for sepsis has shown mixed results reflecting heterogeneous populations, methodologies and interventions.OBJECTIVES: To determine whether the addition of a real-time electronic health record (EHR)-based clinical decision support alert improves adherence to treatment guidelines and clinical outcomes in hospitalised patients with suspected severe sepsis.DESIGN: Patient-level randomisation, single blinded.SETTING: Medical and surgical inpatient units of an academic, tertiary care medical centre.PATIENTS: 1123 adults over the age of 18 admitted to inpatient wards (intensive care units (ICU) excluded) at an academic teaching hospital between November 2014 and March 2015.INTERVENTIONS: Patients were randomised to either usual care or the addition of an EHR-generated alert in response to a set of modified severe sepsis criteria that included vital signs, laboratory values and physician orders.MEASUREMENTS AND MAIN RESULTS: There was no significant difference between the intervention and control groups in primary outcome of the percentage of patients with new antibiotic orders at 3hours after the alert (35% vs 37%, p=0.53). There was no difference in secondary outcomes of in-hospital mortality at 30 days, length of stay greater than 72hours, rate of transfer to ICU within 48hours of alert, or proportion of patients receiving at least 30mL/kg of intravenous fluids.CONCLUSIONS: An EHR-based severe sepsis alert did not result in a statistically significant improvement in several sepsis treatment performance measures.

    View details for PubMedID 30872387

  • A computer vision system for deep learning-based detection of patient mobilization activities in the ICU. NPJ digital medicine Yeung, S., Rinaldo, F., Jopling, J., Liu, B., Mehra, R., Downing, N. L., Guo, M., Bianconi, G. M., Alahi, A., Lee, J., Campbell, B., Deru, K., Beninati, W., Fei-Fei, L., Milstein, A. 2019; 2: 11


    Early and frequent patient mobilization substantially mitigates risk for post-intensive care syndrome and long-term functional impairment. We developed and tested computer vision algorithms to detect patient mobilization activities occurring in an adult ICU. Mobility activities were defined as moving the patient into and out of bed, and moving the patient into and out of a chair. A data set of privacy-safe-depth-video images was collected in the Intermountain LDS Hospital ICU, comprising 563 instances of mobility activities and 98,801 total frames of video data from seven wall-mounted depth sensors. In all, 67% of the mobility activity instances were used to train algorithms to detect mobility activity occurrence and duration, and the number of healthcare personnel involved in each activity. The remaining 33% of the mobility instances were used for algorithm evaluation. The algorithm for detecting mobility activities attained a mean specificity of 89.2% and sensitivity of 87.2% over the four activities; the algorithm for quantifying the number of personnel involved attained a mean accuracy of 68.8%.

    View details for DOI 10.1038/s41746-019-0087-z

    View details for PubMedID 31304360

    View details for PubMedCentralID PMC6550251

  • Physician Burnout in the Electronic Health Record Era RESPONSE ANNALS OF INTERNAL MEDICINE Downing, N., Bates, D. W., Longhurst, C. A. 2019; 170 (3): 216–17

    View details for PubMedID 30716744

  • Improving palliative care with deep learning Avati, A., Jung, K., Harman, S., Downing, L., Ng, A., Shah, N. H. BMC. 2018
  • Occupational exposures and asthma prevalence among US farmworkers: National Agricultural Workers Survey, 2003-2014. The journal of allergy and clinical immunology. In practice Arroyo, A. J., Robinson, L. B., Downing, N. L., Camargo, C. A. 2018

    View details for PubMedID 29626636

  • Health information exchange policies of 11 diverse health systems and the associated impact on volume of exchange. Journal of the American Medical Informatics Association Downing, N. L., Adler-Milstein, J., Palma, J. P., Lane, S., Eisenberg, M., Sharp, C., Longhurst, C. A. 2017; 24 (1): 113-122


    Provider organizations increasingly have the ability to exchange patient health information electronically. Organizational health information exchange (HIE) policy decisions can impact the extent to which external information is readily available to providers, but this relationship has not been well studied.Our objective was to examine the relationship between electronic exchange of patient health information across organizations and organizational HIE policy decisions. We focused on 2 key decisions: whether to automatically search for information from other organizations and whether to require HIE-specific patient consent.We conducted a retrospective time series analysis of the effect of automatic querying and the patient consent requirement on the monthly volume of clinical summaries exchanged. We could not assess degree of use or usefulness of summaries, organizational decision-making processes, or generalizability to other vendors.Between 2013 and 2015, clinical summary exchange volume increased by 1349% across 11 organizations. Nine of the 11 systems were set up to enable auto-querying, and auto-querying was associated with a significant increase in the monthly rate of exchange (P = .006 for change in trend). Seven of the 11 organizations did not require patient consent specifically for HIE, and these organizations experienced a greater increase in volume of exchange over time compared to organizations that required consent.Automatic querying and limited consent requirements are organizational HIE policy decisions that impact the volume of exchange, and ultimately the information available to providers to support optimal care. Future efforts to ensure effective HIE may need to explicitly address these factors.

    View details for DOI 10.1093/jamia/ocw063

    View details for PubMedID 27301748

  • Improving palliative care with deep learning. IEEE International Conference on Bioinformatics and Biomedicine Avati, A., Jung, K., Stephanie, H., Lance, D., Ng, A., Shah, N. 2017
  • Electronic Health Record-Enabled Research in Children Using the Electronic Health Record for Clinical Discovery. Pediatric clinics of North America Sutherland, S. M., Kaelber, D. C., Downing, N. L., Goel, V. V., Longhurst, C. A. 2016; 63 (2): 251-268


    Initially described more than 50 years ago, electronic health records (EHRs) are now becoming ubiquitous throughout pediatric health care settings. The confluence of increased EHR implementation and the exponential growth of digital data within them, the development of clinical informatics tools and techniques, and the growing workforce of experienced EHR users presents new opportunities to use EHRs to augment clinical discovery and improve pediatric patient care. This article reviews the basic concepts surrounding EHR-enabled research and clinical discovery, including the types and fidelity of EHR data elements, EHR data validation/corroboration, and the steps involved in analytical interrogation.

    View details for DOI 10.1016/j.pcl.2015.12.002

    View details for PubMedID 27017033

  • Validation of Test Performance and Clinical Time Zero for an Electronic Health Record Embedded Severe Sepsis Alert. Applied clinical informatics Rolnick, J., Downing, N. L., Shepard, J., Chu, W., Tam, J., Wessels, A., Li, R., Dietrich, B., Rudy, M., Castaneda, L., Shieh, L. 2016; 7 (2): 560-572


    Increasing use of EHRs has generated interest in the potential of computerized clinical decision support to improve treatment of sepsis. Electronic sepsis alerts have had mixed results due to poor test characteristics, the inability to detect sepsis in a timely fashion and the use of outside software limiting widespread adoption. We describe the development, evaluation and validation of an accurate and timely severe sepsis alert with the potential to impact sepsis management.To develop, evaluate, and validate an accurate and timely severe sepsis alert embedded in a commercial EHR.The sepsis alert was developed by identifying the most common severe sepsis criteria among a cohort of patients with ICD 9 codes indicating a diagnosis of sepsis. This alert requires criteria in three categories: indicators of a systemic inflammatory response, evidence of suspected infection from physician orders, and markers of organ dysfunction. Chart review was used to evaluate test performance and the ability to detect clinical time zero, the point in time when a patient develops severe sepsis.Two physicians reviewed 100 positive cases and 75 negative cases. Based on this review, sensitivity was 74.5%, specificity was 86.0%, the positive predictive value was 50.3%, and the negative predictive value was 94.7%. The most common source of end-organ dysfunction was MAP less than 70 mm/Hg (59%). The alert was triggered at clinical time zero in 41% of cases and within three hours in 53.6% of cases. 96% of alerts triggered before a manual nurse screen.We are the first to report the time between a sepsis alert and physician chart-review clinical time zero. Incorporating physician orders in the alert criteria improves specificity while maintaining sensitivity, which is important to reduce alert fatigue. By leveraging standard EHR functionality, this alert could be implemented by other healthcare systems.

    View details for DOI 10.4338/ACI-2015-11-RA-0159

    View details for PubMedID 27437061

    View details for PubMedCentralID PMC4941860

  • An Exponential Increase in Regional Health Information Exchange With Collaborative Policies and Technologies. Studies in health technology and informatics Downing, N. L., Lane, S., Eisenberg, M., Sharp, C., Palma, J., Longhurst, C. 2015; 216: 931-?


    In the United States, the ability to securely exchange health information between organization has been limited by technical interoperability, patient identity matching, and variable institutional policies. Here, we examine the regional experience in a national health information exchange network by examining clinical data sharing between eleven Northern California organizations using the same health information exchange (HIE) platform between 2013-2014. We identify key policies and technologies that have led to a dramatic increase in health information exchange.

    View details for PubMedID 26262233

  • An Exponential Increase in Regional Health Information Exchange With Collaborative Policies and Technologies Downing, N., Lane, S., Eisenberg, M., Sharp, C., Palma, J., Longhurst, C., Northern Calif HIE Working Grp, Sarkar, I. N., Georgiou, A., Marques, P. M. IOS PRESS. 2015: 931
  • COMPARISON OF EARLY REPOLARIZATION IN INFERIOR AND LATERAL LEADS 61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC)/Conference on ACC-i2 with TCT Downing, N. L., Abhimanyu, Uberoi, M., Sallam, K., Sadik, J., Adhikarla, C., Froelicher, V. ELSEVIER SCIENCE INC. 2012: E1940–E1940
  • In Regards to: Dr. N. Lance Downing et al. (Int J Radiat Oncol Biol Physics 2009;75:1064-1070) IN RESPONSE TO DR. H. CHRISTIANSEN ET AL. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Downing, L., Wolden, S., Le, Q. 2010; 76 (5): 1601


    Nasopharyngeal carcinoma (NPC) has a bimodal age distribution. In contrast to the adult variant, little is known about the juvenile form. This study examined the treatment results between adult (aNPC) and juvenile NPC (jNPC) patients for future treatment considerations in jNPC.The jNPC population included 53 patients treated at two institutions between 1972 and 2004. The aNPC population included 84 patients treated at one institution. The patients had received a median dose of 66 Gy of external beam radiotherapy and 72% underwent chemotherapy. The mean follow-up for surviving patients was 12.6 years for jNPC and 6.6 years for aNPC.The jNPC patients presented with more advance stages than did the aNPC patients (92% vs. 67% Stage III-IV, p = .006). However, jNPC patients had significantly better overall survival (OS) than did aNPC patients. The 5-year OS rate was 71% for jNPC and 58% for aNPC (p = .03). The jNPC group also demonstrated a trend for greater relapse-free survival than the aNPC group (5-year relapse-free survival rate, 69% vs. 49%; p = .056). The pattern of failure analysis revealed that the jNPC patients had greater locoregional control and freedom from metastasis but the differences were not statistically significant. Univariate analysis for OS revealed that age group, nodal classification, and chemotherapy use were significant prognostic factors. Age group remained significant for OS on multivariate analysis, after adjusting for N classification and treatment.Despite more advance stage at presentation, jNPC patients had better survival than did aNPC patients. Future treatment strategies should take into consideration the long-term complications in these young patients.

    View details for DOI 10.1016/j.ijrobp.2008.12.030

    View details for PubMedID 19327901

  • Framing physical activity as a distinct and uniquely valuable behavior independent of weight management: A pilot randomized controlled trial for overweight and obese sedentary persons EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY Mascola, A. J., Yiaslas, T. A., Meir, R. L., McGee, S. M., DOWNING, N. L., Beaver, K. M., CRANE, L. B., Agras, S. 2009; 14 (2-3): E148-E152


    Promoting benefits of physical activity independent of weight management may help overweight/obese persons.Pilot randomized-controlled-trial.Twenty-six sedentary, overweight/obese persons receiving health-care at Stanford Medical Center, no contraindications for exercise. CONTROL/INTERVENTION GROUPS: Usual medical care and community weight-management/fitness resources versus same plus a brief intervention derived from behavioral-economic and evolutionary psychological theory highlighting benefits of activity independent of weight-management.Intent-to-treat. Cohen's d effect-sizes and 95% confidence intervals (95%CI) for changes in moderate-intensity-equivalent physical activity/week, cardiorespiratory fitness, and depression at 3 months relative to baseline.Intervention group participants demonstrated 3.76 hour/week of increased physical activity at study endpoint, controls only 0.7 hours/week (Cohen's d=0.74, 95% CI -0.06 to +1.5). They also improved cardiorespiratory fitness (Cohen's d=0.51, 95% CI -0.3 to +1.3) and reduced depression relative to controls (Cohen's d=0.66, 95% CI -0.1 to +1.4).Promoting activity independent of weight-management appears promising for further study.

    View details for Web of Science ID 000272207600018

    View details for PubMedID 19934630

  • Prognostic value of age in nasopharyngeal carcinoma patients: A single institution analysis Downing, N. L., Wong, P., Petrik, D., Hara, W., Le, Q. AMER SOC CLINICAL ONCOLOGY. 2007
  • Towards Vision-Based Smart Hospitals: A System for Tracking and Monitoring Hand Hygiene Compliance Proceedings of the 2nd Machine Learning for Healthcare Conference Haque, A., Guo, M., Alahi, A., Luo, Z., Rege, A., Jopling, J., Downing, L., Beninati, W., Singh, A., Platchek, T., Milstein, A., Fei-Fei, L. 2016