Honors & Awards

  • Identification of causal gene programs for pulmonary arterial hypertension with in vivo Perturb-seq, SNSF Postdoc.Mobility (2025)
  • Molecular basis of human enhanceropathies (ENHPATHY), Marie Skłodowska-Curie Fellowship (2020)

Professional Education

  • PhD, École Polytechnique Fédérale de Lausanne (2025)
  • MS, Higher School of Economics (2020)
  • BS, Higher School of Economics (2018)

Stanford Advisors

Contact

  • Academic
    opushkar@stanford.edu
    University - Scholar Department: Genetics Position: Postdoctoral Scholar

Additional Info

All Publications

  • Chromatin modules and their implication in genomic organization and gene regulation TRENDS IN GENETICS van Mierlo, G., Pushkarev, O., Kribelbauer, J. F., Deplancke, B. 2023; 39 (2): 140-153

    Abstract

    Regulation of gene expression is a complex but highly guided process. While genomic technologies and computational approaches have allowed high-throughput mapping of cis-regulatory elements (CREs) and their interactions in 3D, their precise role in regulating gene expression remains obscure. Recent complementary observations revealed that interactions between CREs frequently result in the formation of small-scale functional modules within topologically associating domains. Such chromatin modules likely emerge from a complex interplay between regulatory machineries assembled at CREs, including site-specific binding of transcription factors. Here, we review the methods that allow identifying chromatin modules, summarize possible mechanisms that steer CRE interactions within these modules, and discuss outstanding challenges to uncover how chromatin modules fit in our current understanding of the functional 3D genome.

    View details for DOI 10.1016/j.tig.2022.11.003

    View details for Web of Science ID 000926012700001

    View details for PubMedID 36549923

https://orcid.org/0000-0002-4208-4498