Dr. Samya Sen is a Postdoc in the Appel Lab at Materials Science and Engineering. He earned his doctorate in mechanical engineering from University of Illinois Urbana-Champaign with Prof. Randy H. Ewoldt. His main research interests are soft materials, rheology, and non-Newtonian fluid mechanics. His current focus is studying the rheology of and developing novel hydrogels for biomedical applications.
Doctor of Philosophy, University of Illinois at Urbana Champaign (2022)
Bachelor of Technology, Indian Institute of Technology, Kharagpur (2017)
Eric Appel, Postdoctoral Faculty Sponsor
Current Research and Scholarly Interests
Samya's research interests are primarily soft materials and complex fluids. He uses experimental techniques of fundamental rheology in conjunction with non-Newtonian fluid mechanics to model, characterize, design, and understand soft material behavior. The applications of his research range from yield-stress fluid design in consumer products, industrial materials, and wildfire suppression. His current research projects as a postdoctoral researcher with Prof. Appel is in the rheological of novel hydrogels for biomedical applications, including improved drug delivery. His focus is on developing transient, stimuli-responsive materials with tunable mechanical and mass transport properties which can be tuned in situ and in vitro for controlled drug-release profiles. He also works on mathematical modeling of mass transport, structural evolution, and constitutive behavior of polymeric and colloidal materials in the context of soft biomaterials.
- Thixotropic spectra and Ashby-style charts for thixotropy JOURNAL OF RHEOLOGY 2022; 66 (5): 1041-1053
- Thixotropy in viscoplastic drop impact on thin films PHYSICAL REVIEW FLUIDS 2021; 6 (4)
- Rheology of fibre suspension flows in the pipeline hydro-transport of biomass feedstock BIOSYSTEMS ENGINEERING 2020; 200: 284-297
- Viscoplastic drop impact on thin films JOURNAL OF FLUID MECHANICS 2020; 891
Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation
2020; 11 (12): 3326-3331
A new type of base-triggered self-amplifying degradable polyurethane is reported that degrades under mild conditions, with the release of increasing amounts of amine product leading to self-amplified degradation. The polymer incorporates a base-sensitive Fmoc-derivative into every repeating unit to enable highly sensitive amine amplified degradation. A sigmoidal degradation curve for the linear polymer was observed consistent with a self-amplifying degradation mechanism. An analogous cross-linked polyurethane gel was prepared and also found to undergo amplified breakdown. In this case, a trace amount of localized base initiates the degradation, which in turn propagates through the material in an amplified manner. The results demonstrate the potential utility of these new generation polyurethanes in enhanced disposability and as stimuli responsive materials.
View details for DOI 10.1039/c9sc06582b
View details for Web of Science ID 000528663000021
View details for PubMedID 34122840
View details for PubMedCentralID PMC8152679
Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2019; 141 (7): 2838-2842
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradation with an acid amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degradation and agent release.
View details for DOI 10.1021/jacs.8b07705
View details for Web of Science ID 000459642000009
View details for PubMedID 30698426