Dr. Sharma’s current endeavor is focused on addressing the critical need for effective therapies in CNS metastases of melanoma, an area in which modern systemic therapy has made minimal progress with patients continuing to show extremely poor outcomes in checkpoint refractory disease. Dr. Sharma has shown an aptitude for meticulous drug development and has rapidly developed important skills in the unique modeling of the metastatic tumor environment. Recently, Saurabh's application was accepted to the SITC Sparkathon-2023 in prestigious program for promising early investigators to develop high priority immunotherapy projects under direct mentorship of society leaders for development of brain nano targeted immunotherapy. Recently he has applied for the 2023 Society for Immunotherapy of Cancer (SITC) Bristol Myers Cancer Immunotherapy Translational Fellowship Award. Prior to joining the Prof. Amanda R. Kirane (Director of cutaneous melanoma surgery) at Surgery Department, Stanford School of Medicine, Stanford university, Dr. Sharma got the opportunity to work on novel immuno-nanoconjugates for brain cancer (Glioblastoma) as a Postdoctoral Chemist and Pharmacologist under the mentorship of Prof. Ali Khademhosseini (Biomaterial, Tissue Engineering Pioneer, EX-MIT and EX-UCLA Professor and Current CEO, Terasaki Institute) and Prof. Eggehard Holler (EX-Director of Nanomedicine, Cedar Sinai Medical Research Center, Los Angeles, California) at Terasaki Institute for Biomedical Innovation, Los Angeles, California, USA. He worked as an assistant Professor at Department of Pharmaceutical Sciences, School of Health Sciences, UPES Dehradun, India. He pursued his Ph.D (Doctoral Degree) from BITS-Pilani, Pilani Campus, Rajasthan, India. During the PhD research work, Dr. Sharma has designed & developed the novel drug delivery systems for the delivery of the genetic materials (e.g., miRNA, siRNA) and chemotherapeutic agents. The research has a significant contribution in the field of developing novel treatment strategies for cancer therapy. He has experienced significant success in his early career, prior to joining post-doctoral program, as evidenced by his guest Speaker in VIT, Parul University and International Virtual Conference on Recent Trends in Life Sciences. He received a Council of Scientific & Industrial Research (CSIR-SRF) Senior Research Fellowship Award and several presentation awards at various International conferences. Further in detail, Dr. Sharma has shown significant success and contribution in his field as evident by: Dr Sharma holds two granted patents one US patent, PCT and other Indian patent in the field of developing novel drug delivery systems. Dr. Sharma published more than 24 publications (Since 2018, Citations:218, h-Index:10, I10-Index:10) his work at Internationally reputed high-Impact factor journal which included: Advance Science, Small, Lab On a Chip, Acta Biomaterialia, Biomaterials Advances (Materials Science and Engineering: C), Nanomedicine: Nanotechnology, Biology and Medicine, Regenerative Biomaterials, Applied Surface Science, Molecular pharmaceutics, International Journal of Pharmaceutics etc several others.
Honors & Awards
SITC Sparkathon Class of 2023, The Society for Immunotherapy of Cancer (SITC) (Sept. 27-29, 2023)
Best New Technology Award at SITC-Sparkathon-2023, The Society for Immunotherapy of Cancer's (SITC) 38th Annual Meeting & Pre-Conference Programs (Nov. 1–5, 2023)
Society For Melanoma Research (SMR) Travel Award on Brain Targeted Nano-Immunotherapy, Society For Melanoma Research (SMR) (6-9 November 2023)
Expert Research Chapter talk on Nanomedicine Platform technology for Cancer treatments, Institute of Biomaterials, Tribocorrosion, Nano and Regenerative Medicine, VIT, Vellore, India (2023)
Amanda Kirane, Postdoctoral Faculty Sponsor
Current Research and Scholarly Interests
We develop strategies to transport immunotherapeutic molecules across the blood-brain barrier for imaging and treating brain metastatic cancer. Currently, under the mentorship of Dr. Amanda Kirane, I have continued my work in cancer-targeted nanotechnology for the treatment of melanoma brain metastases. Immunotherapy of small peptides, small molecules.
- Design, Synthesis, Anticancer and Antimicrobial Studies of 2-Phenylthiazolidin-4-one Glycinamide Conjugates CHEMISTRYSELECT 2023; 8 (42)
- Apatite-coated Ag/AgBr/TiO2 nanocomposites: Insights into the antimicrobial mechanism in the dark and under visible-light irradiation APPLIED SURFACE SCIENCE 2023; 617