Dr. Sethi Dalai is a Clinical Assistant Professor in the Department of Psychiatry and Behavioral Sciences and Director of the Metabolic Psychiatry Clinic, an emerging clinical discipline and focus she started in 2019. She is double board certified in Psychiatry and Obesity Medicine and has additional expertise in adult eating disorders. She completed her residency in Psychiatry at Stanford University and specialized training in obesity at Duke Medical Center. Dr. Sethi Dalai received her MD jointly from Duke University School of Medicine and National University of Singapore. She received a Masters degree in Biotechnology from Johns Hopkins University. Dr. Sethi Dalai’s approach to psychiatric treatment incorporates detection and treatment of metabolic abnormalities, principles of obesity medicine, nutrition and metabolism. She was awarded funding by the Obesity Treatment Foundation and Baszucki Brain Foundation as principal investigator to study the effectiveness of a low - carbohydrate ketogenic dietary intervention in an outpatient cohort of patients with obesity or metabolic dysfunction overlapping with bipolar illness or schizophrenia. In addition, she is a co-investigator on a pilot randomized clinical trial testing an FDA approved obesity medication for binge-eating disorder and bulimia nervosa at Stanford University funded by SPARK. She is a recipient of the Kuen Lau Bipolar Research Award and the Symonds Fellow Award from the Association of Women Psychiatrists for innovation in psychiatry and contributions to women’s health. She is a member of the Obesity Medicine Association, the American Psychiatric Association, and served on the council of the Northern California Psychiatric Association.
- Obesity Medicine
- Adult Eating Disorders
- Metabolic Syndrome
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
Director, Metabolic Psychiatry Clinic, Stanford University School of Medicine (2019 - Present)
Honors & Awards
Kuen Lau Bipolar Research Award, Stanford Department of Psychiatry (2021)
Metabolic Psychiatry Research Fund, Baszucki Brain Foundation (2021)
Obesity Treatment Foundation Grant Award, Obesity Medicine Association (2018)
Symonds Fellow Award, Association of Women Psychiatrists (2016)
ASCP Clinical Trial Scholarship, American Society of Clinical Psychopharmacology (2016)
Recipient, The Coaching Fellowship (2015)
Scholar, Stanford Society of Physician Scholars (2015)
Clinical and Translational Science Award (CTSA) Seed Grant, Stanford Office of Community Health (2010-2012)
Board Certification: American Board of Obesity Medicine, Obesity Medicine (2020)
Board Certification: American Board of Psychiatry and Neurology, Psychiatry (2018)
Residency, Stanford University Medical Center, Psychiatry (2017)
Internship, Stanford University Medical Center, Psychiatry (2014)
MD, National University of Singapore, Medicine (2013)
MD, Duke University School of Medicine, Medicine (2013)
MS, Johns Hopkins University, Biotechnology (2007)
Current Research and Scholarly Interests
Improving metabolic and mental health through dietary interventions, pharmacological optimization, and other lifestyle means in those with severe mental illness, such as bipolar disorder or schizophrenia is a major focus of her research. Clinical and academic interests are also in the management of psychiatric disorders with co-morbid obesity, poor metabolic health and/or eating disorders, particularly binge eating disorder and bulimia nervosa.
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Schizophrenia or Bipolar Illness
To initiate a low-carbohydrate, high-fat (LCHF) ketogenic dietary intervention among a small cohort of outpatients with either schizophrenia or bipolar illness and comorbid overweight/obesity currently taking psychotropic medications. Adults with mental illness represent a high-risk, marginalized group in the current obesity epidemic. Among US adults with severe mental illness, obesity and overweight are highly prevalent conditions having severe consequences, with patients estimated to die on average 25 years earlier than the general population largely of premature cardiovascular disease. In addition, many psychiatric medications, particularly antipsychotics and mood stabilizers, can contribute to metabolic side effects and weight gain. Low-carbohydrate high-fat (LCHF) diets have been shown to reduce cardiovascular risk in those with insulin resistance. The purpose of this study is to evaluate both the metabolic and psychiatric outcomes with an LCHF diet in this psychiatric population.
FDA Approved Medication to Reduce Binge Eating and/or Purging
This study will demonstrate the efficacy of Qsymia versus placebo in treating bulimia nervosa and binge eating disorder.
Stanford is currently not accepting patients for this trial. For more information, please contact Debra L Safer, MD, 650-723-7928.
Treating binge eating and food addiction symptoms with low-carbohydrate ketogenic diets: a case series
Journal of Eating Disorders.
Biomed Central .
Background: Many patients with obesity and comorbid binge eating symptoms present with the desire to lose weight. Although some studies suggest that dietary restriction can exacerbate binge eating, others show dietary restriction is associated with significant reductions in binge eating. The effect of a particular type of dieting on binge eating, the ketogenic diet (a high fat, moderate protein, very low carbohydrate diet), is not known. Case presentations: We report on the feasibility of a low-carbohydrate ketogenic diet initiated by three patients (age 54, 34, and 63) with obesity (average BMI 43.5 kg/m2) with comorbid binge eating and food addiction symptoms. All patients tolerated following the ketogenic diet (macronutrient proportion 10% carbohydrate, 30% protein, and 60% fat; at least 5040 kJ) for the prescribed period (e.g., 6–7 months) and none reported any major adverse effects. Patients reported significant reductions in binge eating episodes and food addiction symptoms including cravings and lack of control as measured by the Binge-Eating Scale, Yale Food Addiction Scale, or Yale- Brown Obsessive-Compulsive Scale modified for Binge Eating, depending on the case. Additionally, the patients lost a range of 10–24% of their body weight. Participants reported maintenance of treatment gains (with respect to weight, binge eating, and food addiction symptoms) to date of up to 9–17 months after initiation and continued adherence to diet. Conclusions: Although the absence of control cases precludes conclusions regarding the specific role of ketogenic diets versus other forms of dietary restriction, this is the first report to demonstrate the feasibility of prescribing a ketogenic diet for patients with obesity who report binge eating and food addiction symptoms. Further research should seek to reproduce the observed effects in controlled trials as well as to explore potential etiologies. Keywords: Binge eating, Food addiction symptoms, Obesity, Ketogenic diet, Dietary restriction
Ketogenic diet as a metabolic treatment for mental Illness.
Current Opinion in Endocrinology, Diabetes and Obesity.
2020 ; 27 (5)
View details for DOI 10.1097/MED.0000000000000564
Low Carbohydrate Ketogenic Therapy as a Metabolic Treatment for Binge Eating and Ultra-processed Food Addiction.
Current Opinion Endocrinology, Diabetes and Obesity
2020; 27 (5)
View details for DOI 10.1097/MED.0000000000000571
- Ketogenic diet as a metabolic therapy for bipolar disorder: Clinical developments Research Square Preprint . 2021
- If Americans were healthier, we could have been better prepared for this pandemic. The Hill Op-Ed. 2020
A randomized, placebo‐controlled crossover trial of phentermine‐topiramate ER in patients with binge‐eating disorder and bulimia nervosa
International Journal of Eating Disorders
View details for DOI 10.1002/eat.23192
Study protocol and rationale for a randomized double-blinded crossover trial of phentermine-topiramate ER versus placebo to treat binge eating disorder and bulimia nervosa.
Contemporary clinical trials
2018; 64: 173–78
Bulimia nervosa (BN) and binge eating disorder (BED) are associated with severe psychological and medical consequences. Current therapies are limited, leaving up to 50% of patients symptomatic despite treatment, underscoring the need for additional treatment options. Qsymia, an FDA-approved medication for obesity, combines phentermine and topiramate ER. Topiramate has demonstrated efficacy for both BED and BN, but limited tolerability. Phentermine is FDA-approved for weight loss. A rationale for combined phentermine/topiramate for BED and BN is improved tolerability and efficacy. While a prior case series exploring Qsymia for BED showed promise, randomized studies are needed to evaluate Qsymia's safety and efficacy when re-purposed in eating disorders. We present a study protocol for a Phase I/IIa single-center, prospective, double-blinded, randomized, crossover trial examining safety and preliminary efficacy of Qsymia for BED and BN.Adults with BED (n=15) or BN (n=15) are randomized 1:1 to receive 12weeks Qsymia (phentermine/topiramate ER, 3.75mg/23mg-15mg/92mg) or placebo, followed by 2-weeks washout and 12-weeks crossover, where those on Qsymia receive placebo and vice versa. Subsequently participants receive 8weeks follow-up off study medications. The primary outcome is the number of binge days/week measured by EDE. Secondary outcomes include average number of binge episodes, percentage abstinence from binge eating, and changes in weight/vitals, eating psychopathology, and mood.To our knowledge this is the first randomized, double-blind protocol investigating the safety and efficacy of phentermine/topiramate in BED and BN. We highlight the background and rationale for this study, including the advantages of a crossover design.Clinicaltrials.gov identifier NCT02553824 registered on 9/17/2015. https://clinicaltrials.gov/ct2/show/NCT02553824.
View details for PubMedID 29038069
- Could Pokémon Go Have Some Mental Health Benefits? American Psychiatric Association . Washington DC. 2016