Siak Lee, BMedSci (Hons), MBBS, FANZCA

All Publications

• Tunneled, Noncuffed, Central Venous Catheters: High Success Rates When Used in Children Less Than 2 Years for Intravenous Antibiotics. Paediatric anaesthesia Lee, S., Browne, W., Voskoboynik, A., Ramesh, S., Hu, Y. J., Brasher, C. 2026; 36 (5): 502-509

  Abstract

  Tunneled noncuffed central venous catheters (tncCVCs) have been used in pediatric populations for years. This study examines whether their use is efficacious and explores the reasons for complications and failure.This 6-year case series examines the success rate of tncCVCs inserted in patients less than 2 years old receiving intravenous antibiotics in a single institution and the reasons for device complications and failure.Three hundred and thirty-one devices were inserted into 311 patients. Median patient age was 0.7 years (IQR 0.15-1.27) and median weight 7.8 kg (4.8-10.6). Median CVC dwell time was 13 (IQR 9.2-18.2) days. The success rate in completing prescribed treatment with the device was 94.9%, with 17 failures. Thirteen failures were due to accidental dislodgement (3.9% of all comers, 77% of failures). A large majority (79%) of patients received outpatient antibiotic therapy. Patients with any history of previous CVC insertion were more likely to have failed devices. All neonatal patient devices successfully completed treatment. A total of 55 different proceduralists inserted the devices.Success rates for tncCVCs when used in infants to complete a median of 13 days of antibiotic therapy on a single device appear acceptable.

  View details for DOI 10.1002/pan.70134

  View details for PubMedID 41636091

• Peripherally inserted central catheters: 100% success providing 13-day antibiotic therapy in cystic fibrosis patients aged 2 to 18 years Pediatric Anesthesia Lee, S., Brasher, C. 2022; 32 (1)
• Transcutaneous carbon dioxide monitoring during procedures requiring sedation and future implications for patients at risk of respiratory depression. Canadian journal of anaesthesia = Journal canadien d'anesthesie Lim, A., Allen, M., Lee, S., Riedel, B. 2018; 65 (9): 1078-1079

  View details for DOI 10.1007/s12630-018-1138-7

  View details for PubMedID 29675733

• Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer' s disease. Current Alzheimer research Bibari, O., Lee, S., Dickson, T. C., Mitew, S., Vickers, J. C., Chuah, M. I. 2013; 10 (7): 688-96

  Abstract

  The aggregation of beta-amyloid (Aβ) into plaques in the extracellular compartment of the brain is a pathological hallmark of Alzheimer' s disease (AD). Although the pathways for misprocessing of Aβ leading to plaque formation are not well understood, they may be related to synapse turnover and neuron activity. In this study, we have utilised transgenic mice co-expressing mutations in the amyloid precursor protein and presenilin 1 genes (APP/PS1) to determine how long-term denervation of the olfactory bulb, a CNS area affected early by AD-like pathology, may affect Aβ plaque formation. The olfactory bulb of pre-symptomatic mice was denervated by ablating the olfactory epithelium unilaterally with Triton X-100 solution. Mice were subjected to nasal washes for a total of 4 or 8 times, at 3-week intervals either with 1% Triton X-100 solution or phosphate buffered saline (sham denervation). Denervation of the olfactory bulb resulted in a statistically significant (p<0.05) decrease in amyloid plaque load in the ipsilateral olfactory bulb, and bilaterally also in the neocortex and hippocampus at 8-9 months age. Amyloid precursor protein was predominantly expressed by mitral cells in the olfactory bulb, which are normally postsynaptic to olfactory axons. The number of APP positive mitral cells was significantly increased in the denervated olfactory bulb of wild type but not of the APP/PS1 mice, which consistently showed high immunoreactivity for APP pre- and post-denervation. In summary, our results show that Aβ plaque deposition in the central nervous system can be modified transsynaptically by deafferentation.

  View details for DOI 10.2174/15672050113109990147

  View details for PubMedID 23905998