Institute Affiliations

Stanford Advisors

Contact

  • Academic
    zhiweili@stanford.edu
    University - Scholar Department: School of Medicine Position: Postdoctoral Scholar

Additional Info

  • Mail Code: 5151

All Publications

  • Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches. The Journal of clinical investigation Kim, M. K., Suh, G. A., Cullen, G. D., Perez Rodriguez, S., Dharmaraj, T., Chang, T. H., Li, Z., Chen, Q., Green, S. I., Lavigne, R., Pirnay, J. P., Bollyky, P. L., Sacher, J. C. 2025; 135 (5)

    Abstract

    Bacteriophage (phage) therapy has emerged as a promising solution to combat the growing crisis of multidrug-resistant (MDR) infections. There are several international centers actively engaged in implementation of phage therapy, and recent case series have reported encouraging success rates in patients receiving personalized, compassionate phage therapy for difficult-to-treat infections. Nonetheless, substantial hurdles remain in the way of more widespread adoption and more consistent success. This Review offers a comprehensive overview of current phage therapy technologies and therapeutic approaches. We first delineate the common steps in phage therapy development, from phage bank establishment to clinical administration, and examine the spectrum of therapeutic approaches, from personalized to fixed phage cocktails. Using the framework of a conventional drug development pipeline, we then identify critical knowledge gaps in areas such as cocktail design, formulation, pharmacology, and clinical trial design. We conclude that, while phage therapy holds promise, a structured drug development pipeline and sustained government support are crucial for widespread adoption of phage therapy for MDR infections.

    View details for DOI 10.1172/JCI187996

    View details for PubMedID 40026251

  • Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches The Journal of Clinical Investigations Kim, M., Suh , G. A., Cullen , G. D., Rodriguez, S. P., Dharmaraj, T., Chang , T. H., Li , Z., Chen, Q., Green, S. I., Lavigne, R., Pirnay, J., Bollyky, P. L., Sacher, J. C. 2025

    View details for DOI 10.1172/JCI187996