Zhiyuan Sun

All Publications

• RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation LIFE SCIENCE ALLIANCE Sun, Z., Dong, P., Yan, H., Wen, X., Li, Y., Jiang, F., Fang, L., Wang, X., Chen, W. 2026; 9 (10)

  Abstract

  Measurement of mRNA translation level has heavily relied on quantifying the amount of polysome-associated RNAs, which would not always reflect efficient translation. To address this, we developed ReleAsing Factor Tethered Editing of RNA (RAFTER), which combined the RNA editing enzyme with translation releasing factor to selectively label successfully translated RNAs. The translation level estimated based on RAFTER correlated well with that by Ribo-seq and Polysome-seq, but with a greatly simplified workflow, which enables it for single-cell analysis.

  View details for DOI 10.26508/lsa.202603651

  View details for Web of Science ID 001828324700001

  View details for PubMedID 42493246

  View details for PubMedCentralID PMC13395895