Independent Labs, Institutes, and Centers (Dean of Research)
Showing 81-100 of 152 Results
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Gheorghe Chistol
Assistant Professor of Chemical and Systems Biology
Current Research and Scholarly InterestsResearch in my laboratory is aimed at understanding how eukaryotes replicate their DNA despite numerous challenges (collectively known as replication stress), and more generally – how eukaryotic cells safeguard genome integrity. Specifically, we are investigating: (i) mechanisms that regulate the activity of the replicative helicase during replication stress, (ii) mechanisms that control the inheritance of epigenetic information during replication, and (iii) mechanisms of ubiquitin-mediated regulation of genome maintenance. We utilize single-molecule microscopy to directly image fluorescently-labeled replication factors and track them in real time in Xenopus egg extracts. I developed this system as a postdoctoral fellow, and used it to monitor how the eukaryotic replicative helicase copes with DNA damage. We plan to further extend the capabilities of this platform to directly visualize other essential replication factors, nucleosomes, and regulatory post-translational modifications like ubiquitin chains. By elucidating molecular mechanisms responsible for maintaining genome stability, we aim to better understand the link between genome instability and cancer, and how these mechanisms can be harnessed to improve disease treatment.
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Bill Chiu
Associate Professor of Surgery (Pediatric Surgery)
BioDr. Chiu obtained his B.S. degree in Biological Sciences and graduated with Honors from Stanford University. After graduating, he received his Medical Degree at Northwestern University Feinberg School of Medicine, where he remained for his internship and General Surgery residency training. Dr. Chiu completed his Pediatric Surgery training at The Children’s Hospital of Philadelphia. He is an Associate Professor at Stanford University School of Medicine where he has an active research program studying innovative approaches to treat patients with neuroblastoma.
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Wah Chiu
Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
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Valerie Chock
Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)
Current Research and Scholarly InterestsNeurological monitoring in critically ill infants. Altered hemodynamics in neonates, especially in relation to prematurity, congenital heart disease, and central nervous system injury. Determination of the hemodynamic significance and effects of a patent ductus arteriosus in the preterm infant. Utilizing NIRS (near-infrared spectroscopy) and other technologies for improved monitoring in the NICU.
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Eun Young Choi, PhD
Instructor, Neurosurgery
Current Research and Scholarly InterestsDr. Choi is broadly interested in mapping the brain’s connectivity and characterizing its functional dynamics using advanced neuroimaging and clinical neurophysiological methods, as well as utilizing this information to identify individual-specific neurosurgical targets for neuromodulation (e.g., deep brain stimulation). Her prior work has mapped the functional and connectional organization of the striatum using neuroimaging and neuroanatomical connectivity methods. She is currently focused on the use of thalamic deep brain stimulation to improve memory and attention in traumatic brain injury and Alzheimer’s disease.
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Danny Hung-Chieh Chou
Assistant Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
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Angele Christin
Associate Professor of Communication and, by courtesy, of Sociology
Current Research and Scholarly InterestsAngèle Christin studies how algorithms and analytics transform professional values, expertise, and work practices.
Her book, Metrics at Work: Journalism and the Contested Meaning of Algorithms (Princeton University Press, 2020) focuses on the case of web journalism, analyzing the growing importance of audience data in web newsrooms in the U.S. and France. Drawing on ethnographic methods, Angèle shows how American and French journalists make sense of traffic numbers in different ways, which in turn has distinct effects on the production of news in the two countries. She discussed it on the New Books Network podcast.
In a related study, she analyzed the construction, institutionalization, and reception of predictive algorithms in the U.S. criminal justice system, building on her previous work on the determinants of criminal sentencing in French courts.
Her new project examines the paradoxes of algorithmic labor through a study of influencers and influencer marketing on YouTube, Instagram, and TikTok. -
Constance Chu, MD
Professor of Orthopaedic Surgery (Sports Medicine)
BioDr. Constance R. Chu is Professor and Vice Chair Research, in the Department of Orthopedic Surgery at Stanford University. She is also Director of the Joint Preservation Center and Chief of Sports Medicine at the VA Palo Alto. Previously, she was the Albert Ferguson Endowed Chair and Professor of Orthopaedic Surgery at the University of Pittsburgh. She is a clinician-scientist who is both principal investigator of several projects funded by the National Institutes of Health and who has been recognized as a Castle-Connelly/US News and World Report “Top Doctor” in Orthopedic Surgery as well as on Becker’s list of Top Knee Surgeons in the United States. Her clinical practice focuses on the knee: primarily restoration and reconstruction of the ACL, menisci and cartilage. She graduated from the U.S. Military Academy at West Point and earned her medical degree from Harvard Medical School.
As Director of the multi-disciplinary Joint Preservation Center structured to seamlessly integrate the latest advances in biologics, mechanics, and imaging with comprehensive patient centered musculoskeletal and orthopedic care, Dr. Chu aims to develop a new model for health care delivery, research and education with an emphasis on health promotion and prevention. Cornerstones of this program include teamwork and a focus on personalized medicine. A central goal is to transform the clinical approach to osteoarthritis from palliation to prevention. In addition to optimizing clinical operations, outstanding research is critical to developing more effective new treatments. Towards this end, Dr. Chu is leading innovative translational research from bench to bedside in three main areas: quantitative imaging and biomarker development for early diagnosis and staging of joint and cartilage injury and degeneration; cartilage tissue engineering and stem cell based cartilage repair; and molecular and biological therapies for joint restoration and joint rejuvenation. Her research efforts have led to more than 30 professional awards and honors to include a Kappa Delta Award, considered to be the highest research honor in Orthopedic Surgery.
Dr. Chu also regularly holds leadership and committee positions in major professional organizations such as the American Association of Orthopedic Surgeons (AAOS) and the American Orthopedic Association (AOA). In her subspecialty of Orthopedic Sports Medicine, she is a past President of the Forum Sports Focus Group, a member of the Herodicus Society of leaders in Sports Medicine, and immediate past Chair of the American Orthopedic Society for Sports Medicine (AOSSM) Research Council. She is alumnus of the AOA American, British, Canadian (ABC) and the AOSSM Traveling Fellowships. -
Gilbert Chu
Professor of Medicine (Oncology) and of Biochemistry
Current Research and Scholarly InterestsAfter shuttering the wet lab, we have focused on: a point-of-care device to measure blood ammonia and prevent brain damage; a human protein complex that juxtaposes and joins DNA ends for repair and V(D)J recombination; and strategies for teaching students and for reducing selection bias in educational programs.
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Lawrence Chu, MD, MS
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsI have two lines of research, one involving educational informatics and use of technology in postgraduate medical education and another involving NIH-funded work in patient-oriented clinical research regarding opioid use and physiologic responses associated with acute and chronic exposure in humans.
For a full description of my educational informatics work, please see my website aim.stanford.edu.
My clinical research focuses on the study opiate-induced hyperalgesia in patients suffering from chronic pain.
I am currently conducting an NIH-funded five year double-blinded randomized controlled clinical study (NIGMS award 1K23GM071400-01) that prospectively examines the following hypotheses: 1) pain patients on chronic opioid therapy develop dose-dependent tolerance and/or hyperalgesia to these medications over time, 2) opiate-induced tolerance and hyperalgesia develop differently with respect to various types of pain, 3) opioid-induced hyperalgesia occurs independently of withdrawal phenomena, and 4) opiate-induced tolerance and hyperalgesia develop differently based on gender and/or ethnicity.
The study is the first quantitative and prospective examination of tolerance and hyperalgesia in pain patients and may have important implications for the rational use of opioids in the treatment of chronic pain. -
Steven Chu
William R. Kenan Jr. Professor, Professor of Molecular and Cellular Physiology and of Energy Science and Engineering
Current Research and Scholarly InterestsSynthesis, functionalization and applications of nanoparticle bioprobes for molecular cellular in vivo imaging in biology and biomedicine. Linear and nonlinear difference frequency mixing ultrasound imaging. Lithium metal-sulfur batteries, new approaches to electrochemical splitting of water. CO2 reduction, lithium extraction from salt water
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Katrin Chua
Professor of Medicine (Endocrinology, Gerontology and Metabolism)
On Leave from 10/01/2023 To 07/31/2024Current Research and Scholarly InterestsOur lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
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William Chueh
Associate Professor of Materials Science and Engineering, of Energy Science and Engineering, of Photon Science, and Senior Fellow at the Precourt Institute for Energy
BioThe availability of low-cost but intermittent renewable electricity (e.g., derived from solar and wind) underscores the grand challenge to store and dispatch energy so that it is available when and where it is needed. Redox-active materials promise the efficient transformation between electrical, chemical, and thermal energy, and are at the heart of carbon-neutral energy cycles. Understanding design rules that govern materials chemistry and architecture holds the key towards rationally optimizing technologies such as batteries, fuel cells, electrolyzers, and novel thermodynamic cycles. Electrochemical and chemical reactions involved in these technologies span diverse length and time scales, ranging from Ångströms to meters and from picoseconds to years. As such, establishing a unified, predictive framework has been a major challenge. The central question unifying our research is: “can we understand and engineer redox reactions at the levels of electrons, ions, molecules, particles and devices using a bottom-up approach?” Our approach integrates novel synthesis, fabrication, characterization, modeling and analytics to understand molecular pathways and interfacial structure, and to bridge fundamentals to energy storage and conversion technologies by establishing new design rules.
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Benjamin I. Chung
Associate Professor of Urology
Current Research and Scholarly InterestsRenal cell carcinoma and prostate cancer outcomes research and epidemiology.
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Karlene Cimprich
Professor of Chemical and Systems Biology and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsGenomic instability contributes to many diseases, but it also underlies many natural processes. The Cimprich lab is focused on understanding how mammalian cells maintain genomic stability in the context of DNA replication stress and DNA damage. We are interested in the molecular mechanisms underlying the cellular response to replication stress and DNA damage as well as the links between DNA damage and replication stress to human disease.
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Thomas J Cirino
Research Scientist, Animal Pharmacology, Innovative Medicines Accelerator (IMA)
BioIn Vivo Pharmacologist with expertise in CNS disorders including neurodegenerative disease, psychiatric disorders and pain.
