Bio-X


Showing 1-10 of 60 Results

  • Harvey Cohen

    Harvey Cohen

    Deborah E. Addicott - John A. Kriewall and Elizabeth A. Haehl Family Professor in Pediatrics

    Current Research and Scholarly InterestsMy research interests extend from hypothesis-driven studies in biochemistry and cell biology to discovery-driven interests in proteomics and systems biology to clinical treatment of acute lymphoblastic leukemia of children, and pediatric palliative care.

  • Thomas Clandinin

    Thomas Clandinin

    Shooter Family Professor

    Current Research and Scholarly InterestsThe Clandinin lab focuses on understanding how neuronal circuits assemble and function to perform specific computations and guide behavior. Taking advantage of a rich armamentarium of genetic tools available in the fruit fly, combined with imaging, physiology and analytical techniques drawn from systems neuroscience, we examine a variety of visual circuits.

  • James K. Chen

    James K. Chen

    Professor of Chemical and Systems Biology and of Developmental Biology and, by courtesy, of Chemistry

    Current Research and Scholarly InterestsOur laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.

  • Christopher H. Contag

    Christopher H. Contag

    Professor of Pediatrics (Neonatology), Emeritus

    Current Research and Scholarly InterestsWe develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

  • Michele Calos

    Michele Calos

    Professor of Genetics

    Current Research and Scholarly InterestsMy lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.

    We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.

    We are working on 3 forms of muscular dystrophy.

    We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.

  • Patricia Cross

    Patricia Cross

    Professor (Teaching) of Structural Biology, Emerita

    Current Research and Scholarly InterestsI am not now actively involved in research, but my past endeavors remain central to my position in guiding medical students in their scholarship pursuits.
    The cited publications represent three areas of interest:
    (1) medical student research (Jacobs and Cross)
    (2) women in medicine (Cross and Steward)
    (3) the reproductive physiology of early development (Cross and Brinster)
    Only one publication is listed in this area since the research is not current, but others (in e.g. Nature, DevBiol, ExpCellRes) give a broader picture of my pursuit when at the University of Pennsylvania.

  • John P. Cooke, MD, PhD

    John P. Cooke, MD, PhD

    Professor of Medicine (Cardiovascular Medicine), Emeritus

    Current Research and Scholarly InterestsOur translational research program in vascular regeneration is focused on generating and characterizing vascular cells from human induced pluripotential stem cells. We are also studying the therapeutic application of these cells in murine models of peripheral arterial disease. In these studies we leverage our longstanding interest in endothelial signaling, eg by nitric oxide synthase (NOS) as well as by nicotinic cholinergic receptors (nAChR).

  • Gilbert Chu

    Gilbert Chu

    Professor of Medicine (Oncology) and of Biochemistry

    Current Research and Scholarly InterestsOur laboratory seeks to understand how cells repair DNA damage. We currently focus on how non-homologous end joining proteins assemble on DNA ends to juxtapose them for repair of DNA double-strand breaks.

    We are collaborating in the development of a point-of-care device to measure ammonia from a drop of blood. The device will facilitate diagnosis and management of urea cycle defects, liver disease, and chemobrain due to elevated ammonia.

  • Christos E. Constantinou

    Christos E. Constantinou

    Associate Professor of Urology, Emeritus

    Current Research and Scholarly InterestsMy main recent interest is the application of Biomedical Engineering approaches for the clinical visualization and characterization of the static and dynamic properties of pelvic floor function. This extends to ultrasound Imaging and image processing, construction of computer models and biomechanics analysis of pelvic floor function. It is envisioned that these considerations are important constituents of the clinical evaluation of patients with lower urinary tract dysfunction and urodynamics.

  • Mike Cherry

    Mike Cherry

    Professor (Research) of Genetics

    Current Research and Scholarly InterestsMy research involves identifying, validating and integrating scientific facts into encyclopedic databases essential for research and scientific education. Published results of scientific experimentation are a foundation of our understanding of the natural world and provide motivation for new experiments. The combination of in-depth understanding reported in the literature with computational analyses is an essential ingredient of modern biological research.