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Professor of Genetics
Current Research and Scholarly InterestsMy lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.
We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.
We are working on 3 forms of muscular dystrophy.
We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.
Assistant Professor of Bioengineering and, by courtesy, of Neurosurgery and of Mechanical Engineering
Current Research and Scholarly InterestsThe Camarillo Lab is currently instrumenting Stanford athletes with inertial sensors to investigate the mechanism of concussion. Additionally, the lab is researching cell mechanics for regenerative medicine. We are developing a quantitative, noninvasive and early measure of viability in order to allow clinicians to transfer the single most viable embryo. Other research area is in medical instrumentation as it pertains to robotic catheterization for curing cardiac arrhythmia.
Barnum-Simons Chair in Math and Statistics, and Professor of Statistics and, by courtesy, of Electrical Engineering
BioEmmanuel Candès is the Barnum-Simons Chair in Mathematics and Statistics, a professor of electrical engineering (by courtesy) and a member of the Institute of Computational and Mathematical Engineering at Stanford University. Earlier, Candès was the Ronald and Maxine Linde Professor of Applied and Computational Mathematics at the California Institute of Technology. His research interests are in computational harmonic analysis, statistics, information theory, signal processing and mathematical optimization with applications to the imaging sciences, scientific computing and inverse problems. He received his Ph.D. in statistics from Stanford University in 1998.
Candès has received several awards including the Alan T. Waterman Award from NSF, which is the highest honor bestowed by the National Science Foundation, and which recognizes the achievements of early-career scientists. He has given over 60 plenary lectures at major international conferences, not only in mathematics and statistics but in many other areas as well including biomedical imaging and solid-state physics. He was elected to the National Academy of Sciences and to the American Academy of Arts and Sciences in 2014.
Associate Professor of Microbiology and Immunology
Current Research and Scholarly InterestsOur research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.
Victor G. Carrion
John A. Turner Endowed Professor for Child and Adolescent Psychiatry
Current Research and Scholarly InterestsExamines the interplay between brain development and stress vulnerability via a multi-method approach that includes psychophysiology, neuroimaging, neuroendocrinology and phenomenology. Treatment development that focuses on individual and community-based interventions for stress related conditions in children and adolescents that experience traumatic stress.
Dennis R Carter
Professor of Mechanical Engineering, Emeritus
Current Research and Scholarly InterestsProfessor Carter studies the influence of mechanical loading upon the growth, development, regeneration, and aging of skeletal tissues. Basic information from such studies is used to understand skeletal diseases and treatments. He has served as President of the Orthopaedic Research Society and is a Fellow of the American Institute for Medical and Biological Engineering.
Associate Professor of Earth System Science and Senior Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsAssistant Professor in EESS, focus on marine chemistry and biogeochemistry.
Associate Professor of Chemistry and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsOur research program integrates chemistry, biology, and physics to investigate the assembly and function of macromolecular and whole-cell systems. The genomics and proteomics revolutions have been enormously successful in generating crucial "parts lists" for biological systems. Yet, for many fascinating systems, formidable challenges exist in building complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell factories. We are inspired by the need for new and unconventional approaches to solve these outstanding problems and to drive the discovery of new therapeutics for human disease.
Our approach is different from the more conventional protein-structure determinations of structural biology. We employ biophysical and biochemical tools, and are designing new strategies using solid-state NMR spectroscopy to examine assemblies such as amyloid fibers, bacterial cell walls, whole cells, and biofilms. We would like to understand at a molecular and atomic level how bacteria self-assemble extracellular structures, including functional amyloid fibers termed curli, and how bacteria use such building blocks to construct organized biofilm architectures. We also employ a chemical genetics approach to recruit small molecules as tools to interrupt and interrogate the temporal and spatial events during assembly processes and to develop new strategies to prevent and treat infectious diseases. Overall, our approach is multi-pronged and provides training opportunities for students interested in research at the chemistry-biology interface.
Duca Family Professor
BioChris Chafe is a composer, improvisor and cellist, developing much of his music alongside computer-based research. He is Director of Stanford University's Center for Computer Research in Music and Acoustics (CCRMA). At IRCAM (Paris) and The Banff Centre (Alberta), he pursued methods for digital synthesis, music performance and real-time internet collaboration. CCRMA's SoundWIRE project involves live concertizing with musicians the world over. Online collaboration software including jacktrip and research into latency factors continue to evolve. An active performer either on the net or physically present, his music reaches audiences in dozens of countries and sometimes at novel venues. A simultaneous five-country concert was hosted at the United Nations in 2009. Chafe's works are available from Centaur Records and various online media. Gallery and museum music installations are into their second decade with "musifications" resulting from collaborations with artists, scientists and MD's. Recent works include Tomato Quintet for the transLife:media Festival at the National Art Museum of China, Phasor for contrabass and Sun Shot played by the horns of large ships in the port of St. Johns, Newfoundland. Chafe premiered DiPietro's concerto, Finale, for electric cello and orchestra in 2012.
Professor of Geological Sciences
Current Research and Scholarly InterestsResearch
I use stable and radiogenic isotopes to understand Earth system history. These studies examine the link between climate, tectonics, biological, and surface processes. Projects include: 1) examining the terrestrial climate history of the Earth focusing on periods of time in the past that had CO 2-levels similar to the present and to future projections; and 2) addressing how the chemical weathering of the Earth's crust affects both the long- and short-term carbon cycle. Field areas for these studies are in the Cascades, Rocky Mountains, Sierra Nevada, the European Alps, Tibet and the Himalaya and the Southern Alps of New Zealand.
I teach courses at the undergraduate and graduate level in isotope biogeochemistry, Earth system history, and the relationship between climate, surface processes and tectonics. I also teach a three-week field course each September in the Wind River Mountains of Wyoming for sophomores and GES majors. This course covers topics in environmental and geological sciences.
Editor American Journal of Science; Co-Director Stanford Stable Isotope Biogeochemistry Laboratory (present);Chair, Department of Geological and Environmental Sciences (2004-07); Co-Director Stanford/USGS SHRIMP Ion microprobe facility (2001-04)