Showing 1-20 of 55 Results
Stephen J. Galli, MD
The Mary Hewitt Loveless, M.D. Professor in the School of Medicine and Professor of Pathology and of Microbiology and Immunology
Current Research and Scholarly InterestsThe goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease. We study both the roles of mast cells, basophils, and IgE in normal physiology and host defense, e.g., in responses to parasites and in enhancing resistance to venoms, and also their roles in pathology, e.g., anaphylaxis, food allergy, and asthma, both in mice and humans.
Sanjiv Sam Gambhir, MD, PhD
Current Research and Scholarly InterestsMy laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the field of molecular imaging. Imaging for the purpose of better understanding cancer biology and applications in gene and cell therapy, as well as immunotherapy are all being studied. A key long-term focus is the earlier detection of cancer by combining in vitro diagnostics and molecular imaging.
Associate Professor of Applied Physics and , by courtesy, of Neurobiology and of Electrical Engineering
Current Research and Scholarly InterestsTheoretical / computational neuroscience
Assistant Professor of Chemical Engineering
BioHow do we design biological systems as “smart medicine” that sense patients’ states, process the information, and respond accordingly? To realize this vision, we will tackle fundamental challenges across different levels of complexity, such as (1) protein components that minimize their crosstalk with human cells and immunogenicity, (2) biomolecular circuits that function robustly in different cells and are easy to deliver, (3) multicellular consortia that communicate through scalable channels, and (4) therapeutic modules that interface with physiological inputs/outputs. Our engineering targets include biomolecules, molecular circuits, viruses, and cells, and our approach combines quantitative experimental analysis with computational simulation. The molecular tools we build will be applied to diverse fields such as neurobiology and cancer therapy.
Alan M. Garber
Henry J. Kaiser Jr. Professor and Professor of Medicine, Emeritus
Current Research and Scholarly InterestsTopics in the health economics of aging; health, insurance; optimal screening intervals; cost-effectiveness of, coronary surgery in the elderly; health care financing and delivery, in the United States and Japan; coronary heart disease
Younger Family Professor and Professor of Structural Biology
Current Research and Scholarly InterestsStructural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.
Assistant Professor of Psychology
Current Research and Scholarly InterestsHow does neural activity in the human cortex create our sense of visual perception? We use a combination of functional magnetic resonance imaging, computational modeling and analysis, and psychophysical measurements to link human perception to cortical brain activity.
Associate Professor of Comparative Medicine and, by courtesy, of Psychiatry and Behavioral Sciences at the Stanford University Medical Center
Current Research and Scholarly InterestsThe medical research community has long recognized that good well-being is good science. The lab uses an integrated interdisciplinary approach to explore this interface, while providing tangible deliverables for the well-being of human patients and research animals.
Assistant Professor (Research) of Medicine (Biomedical Informatics) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsComputational systems biology of human disease. Particular focus on integration of high-throughput datasets with each other, and with phenotypic information and clinical outcomes.
Paul George, MD, PhD
Assistant Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsCONDUCTIVE POLYMER SCAFFOLDS FOR STEM CELL-ENHANCED STROKE RECOVERY:
We focus on developing conductive polymers for stem cell applications. We have created a microfabricated, polymeric system that can continuously interact with its biological environment. This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.
BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery. Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes.
Senior Associate Dean for Educational Affairs, Professor of Energy Resources Engineering, Senior Fellow at the Precourt Institute for Energy and Professor, by courtesy, of Civil and Environmental Engineering
Current Research and Scholarly InterestsResearch
My work is about understanding and simulating complicated fluid flow problems. My research focuses on the design of highly accurate and efficient parallel computational methods to predict the performance of enhanced oil recovery methods. I'm particularly interested in gas injection and in-situ combustion processes. These recovery methods are extremely challenging to simulate because of the very strong nonlinearities in the governing equations. Outside petroleum engineering, I'm active in coastal ocean simulation with colleagues from the Department of Civil and Environmental Engineering, yacht research and pterosaur flight mechanics with colleagues from the Department of Mechanical and Aeronautical Engineering, and the design of search algorithms in collaboration with the Library of Congress and colleagues from the Institute of Computational and Mathematical Engineering.
I teach courses in both energy related topics (reservoir simulation, energy, and the environment) in my department, and mathematics for engineers through the Institute of Computational and Mathematical Engineering (ICME). I also initiated two courses in professional development in our department (presentation skills and teaching assistant training), and a consulting course for graduate students in ICME, which offers expertise in computational methods to the Stanford community and selected industries.
Senior Associate Dean, School of Earth, Energy and Environmental Sciences, Stanford (from 2015); Director, Institute for Computational and Mathematical Engineering, Stanford (from 2010); Stanford Fellow (2010-2012); Magne Espedal Professor II, Bergen University (2011-2014); Aldo Leopold Fellow (2009); Chair, SIAM Activity group in Geosciences (2007, present, reelected in 2009); Faculty Research Fellow, Clayman Institute (2008); Elected to Council of Society of Industrial and Applied Mathematics (SIAM) (2007); organizing committee, 2008 Gordon Conference on Flow in Porous Media; producer, Smart Energy podcast channel; Director, Stanford Yacht Research; Co-director and founder, Stanford Center of Excellence for Computational Algorithms in Digital Stewardship; Editor, Journal of Small Craft Technology; Associate editor, Transport in Porous Media; Reviewer for various journals and organizations including SPE, DoE, NSF, Journal of Computational Physics, Journal of Scientific Computing, Transport in Porous Media, Computational Geosciences; member, SIAM, SPE, KIVI, AGU, and APS
Assistant Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science
Current Research and Scholarly InterestsMy lab focuses on biomedical data fusion: the development of machine learning methods for biomedical decision support using multi-scale biomedical data. We primarily use methods based on regularized linear regression to accomplish this. We primarily focus on applications in oncology and neuroscience.
Amato J. Giaccia
Jack, Lulu and Sam Willson Professor, Professor of Radiation Oncology, Emeritus
Current Research and Scholarly InterestsDuring the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.
Assistant Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsGlia make up more than half of the cells in the human brain, but we are just beginning to understand the complex and multifactorial role glia play in health and disease. Glia are decidedly dynamic in form and function. Understanding the mechanisms underlying this dynamic nature of glia is imperative to developing novel therapeutic strategies for diseases of the nervous system that involve aberrant gliogenesis, especially related to changes in myelination.
Professor of Anesthesiology, Perioperative and Pain Medicine, Emerita
Current Research and Scholarly InterestsAstrocytes, microglia and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles. We focus on the cellular and molecular basis of brain cell injury in stroke. We study the effects of altering miRNA expression, altering levels of heat shock and cell death regulatory proteins. Our goal is to improve outcome by improving mitochondrial function and brain cell survival, and reducing oxidative stress and inflammation.
Professor of Biology
Current Research and Scholarly InterestsMy work has contributed to understanding electrical excitability in nerve & muscle in organisms ranging from brittle-stars to mammals. Current research addresses behavior, physiology and ecology of squid through field and lab approaches. Electronic tagging plus in situ video, acoustic and oceanographic methods are used to study behaviors and life history in the field. Lab work focuses on control of chromogenic behavior by the chromatophore network and of locomotion by the giant axon system.
Associate Professor of Neurobiology
Current Research and Scholarly InterestsMy laboratory studies the cellular and molecular mechanisms underlying the organization of cortical circuits important for spatial navigation and memory. We are particularly focused on medial entorhinal cortex, where many neurons fire in spatially specific patterns and thus offer a measurable output for molecular manipulations. We combine electrophysiology, genetic approaches and behavioral paradigms to unravel the mechanisms and behavioral relevance of non-sensory cortical organization. Our first line of research is focused on determining the cellular and molecular components crucial to the neural representation of external space by functionally defined cell types in entorhinal cortex (grid, border and head direction cells). We plan to use specific targeting of ion channels, combined with in vivo tetrode recordings, to determine how channel dynamics influence the neural representation of space in the behaving animal. A second, parallel line of research, utilizes a combination of in vivo and in vitro methods to further parse out ionic expression patterns in entorhinal cortices and determine how gradients in ion channels develop. Ultimately, our work aims to understand the ontogenesis and relevance of medial entorhinal cortical topography in spatial memory and navigation.
Nicholas Giori MD, PhD
Professor of Orthopaedic Surgery at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly InterestsOsteoarthritis
Medical Device Development
Aaron D. Gitler
The Stanford Medicine Basic Science Professor
Current Research and Scholarly InterestsWe investigate the mechanisms of human neurodegenerative diseases, including Alzheimer disease, Parkinson disease, and ALS. We don't limit ourselves to one model system or experimental approach. We start with yeast, perform genetic and chemical screens, and then move to other model systems (e.g. mammalian tissue culture, mouse, fly) and even work with human patient samples (tissue sections, patient-derived cells, including iPS cells) and next generation sequencing approaches.
Stanley McCormick Memorial Professor in the School of Medicine, Emerita
Current Research and Scholarly InterestsOur research is in reproductive endocrinology and reproductive genomics. It focuses on human endometrial biology as it relates to basic biological mechanisms underlying steroid hormone action in this tissue, normal and abnormal placenta-decidua interactions, mechanisms underlying placentation and abnormal fetal growth, endometrial stem cells, and functional genomics for diagnostics and therapeutics of endometrial disorders. We also study mechanisms underlying ovarian follicle steroidogenesis.