Showing 1-20 of 63 Results
Stephen J. Galli, MD
Mary Hewitt Loveless, MD, Professor in the School of Medicine and Professor of Pathology and of Microbiology and Immunology
Current Research and Scholarly InterestsThe goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease. We study both the roles of mast cells, basophils, and IgE in normal physiology and host defense, e.g., in responses to parasites and in enhancing resistance to venoms, and also their roles in pathology, e.g., anaphylaxis, food allergy, and asthma, both in mice and humans.
Sanjiv Sam Gambhir, MD, PhD
Current Research and Scholarly InterestsMy laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the field of molecular imaging. Imaging for the purpose of better understanding cancer biology and applications in gene and cell therapy, as well as immunotherapy are all being studied. A key long-term focus is the earlier detection of cancer by combining in vitro diagnostics and molecular imaging.
Associate Professor of Applied Physics and, by courtesy, of Neurobiology and of Electrical Engineering
Current Research and Scholarly InterestsTheoretical / computational neuroscience
Assistant Professor of Biochemistry
Current Research and Scholarly InterestsNature has created many powerful biomolecules that are hidden in organisms across kingdoms of life. Many of these biomolecules originate from microbes, which contain the most diverse gene pool among living organisms. We are integrating high-throughput computational and experimental approaches to harness the vast diversity of genes in microbes to develop new antibiotics and molecular biotechnology, and to investigate the evolution of proteins and molecular mechanisms in innate immunity.
Assistant Professor of Chemical Engineering
Current Research and Scholarly InterestsHow do we design biological systems as “smart medicine” that sense patients’ states, process the information, and respond accordingly? To realize this vision, we will tackle fundamental challenges across different levels of complexity, such as (1) protein components that minimize their crosstalk with human cells and immunogenicity, (2) biomolecular circuits that function robustly in different cells and are easy to deliver, (3) multicellular consortia that communicate through scalable channels, and (4) therapeutic modules that interface with physiological inputs/outputs. Our engineering targets include biomolecules, molecular circuits, viruses, and cells, and our approach combines quantitative experimental analysis with computational simulation. The molecular tools we build will be applied to diverse fields such as neurobiology and cancer therapy.
Alan M. Garber
Henry J. Kaiser Jr. Professor and Professor of Medicine, Emeritus
Current Research and Scholarly InterestsTopics in the health economics of aging; health, insurance; optimal screening intervals; cost-effectiveness of, coronary surgery in the elderly; health care financing and delivery, in the United States and Japan; coronary heart disease
Younger Family Professor and Professor of Structural Biology
Current Research and Scholarly InterestsStructural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.
Associate Professor of Psychology
Current Research and Scholarly InterestsHow does neural activity in the human cortex create our sense of visual perception? We use a combination of functional magnetic resonance imaging, computational modeling and analysis, and psychophysical measurements to link human perception to cortical brain activity.
Professor of Comparative Medicine and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsThe medical research community has long recognized that "good well-being is good science". The lab uses an integrated interdisciplinary approach to explore this interface, while providing tangible deliverables for the well-being of human patients and research animals.
Assistant Professor of Microbiology and of Bioengineering
BioMatthias Garten, Ph.D., is an assistant professor in the department of Immunology and Microbiology and the department of Bioengineering. He is a membrane biophysicist who is driven by the question of how the malaria parasite interfaces with its host-red blood cell, how we can use the unique mechanisms of the parasite to treat malaria and to re-engineer cells for biomedical applications.
He obtained a physics master's degree from the Dresden University of Technology, Germany with a thesis in the laboratory of Dr. Petra Schwille and his Ph.D. life sciences from the University Paris Diderot, France through his work in the lab of Dr. Patricia Bassereau (Insitut Curie) investigating electrical properties of lipid membranes and protein - membrane interactions using biomimetic model systems, giant liposomes and planar lipid membranes.
In his post-doctoral work at the National Institutes of Health, Bethesda in the laboratory of Dr. Joshua Zimmerberg, he used molecular, biophysical and quantitative approaches to research the malaria parasite. His work led to the discovery of structure-function relationships that govern the host cell – parasite interface, opening research avenues to understand how the parasite connects to and controls its host cell.
Assistant Professor of Medicine (Primary Care and Population Health) and, by courtesy, of Epidemiology and Population Health
BioPascal Geldsetzer is an Assistant Professor of Medicine in the Division of Primary Care and Population Health and, by courtesy, in the Department of Epidemiology and Population Health. He is also affiliated with the Department of Biomedical Data Science, Department of Health Policy, King Center for Global Development, and the Stanford Centers for Population Health Sciences, Innovation in Global Health, and Artificial Intelligence in Medicine & Imaging.
His research focuses on identifying and evaluating the most effective interventions for improving health at older ages. In addition to leading several randomized trials, his methodological emphasis lies on the use of quasi-experimental approaches to ascertain causal effects in large observational datasets, particularly in electronic health record data. He has won an NIH New Innovator Award (in 2022), a Chan Zuckerberg Biohub investigatorship (in 2022), and two NIH R01 grants as Principal Investigator (both in 2023).
Assistant Professor (Research) of Pathology, of Medicine (BMIR) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsComputational systems biology of human disease. Particular focus on integration of high-throughput datasets with each other, and with phenotypic information and clinical outcomes.
Paul George, MD, PhD
Assistant Professor of Neurology and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsCONDUCTIVE POLYMER SCAFFOLDS FOR STEM CELL-ENHANCED STROKE RECOVERY:
We focus on developing conductive polymers for stem cell applications. We have created a microfabricated, polymeric system that can continuously interact with its biological environment. This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.
BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery. Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes.
Professor of Energy Resources Engineering, Emerita
Current Research and Scholarly InterestsResearch
My work is about understanding and simulating complicated fluid flow problems. My research focuses on the design of highly accurate and efficient parallel computational methods to predict the performance of enhanced oil recovery methods. I'm particularly interested in gas injection and in-situ combustion processes. These recovery methods are extremely challenging to simulate because of the very strong nonlinearities in the governing equations. Outside petroleum engineering, I'm active in coastal ocean simulation with colleagues from the Department of Civil and Environmental Engineering, yacht research and pterosaur flight mechanics with colleagues from the Department of Mechanical and Aeronautical Engineering, and the design of search algorithms in collaboration with the Library of Congress and colleagues from the Institute of Computational and Mathematical Engineering.
I teach courses in both energy related topics (reservoir simulation, energy, and the environment) in my department, and mathematics for engineers through the Institute of Computational and Mathematical Engineering (ICME). I also initiated two courses in professional development in our department (presentation skills and teaching assistant training), and a consulting course for graduate students in ICME, which offers expertise in computational methods to the Stanford community and selected industries.
Senior Associate Dean, School of Earth, Energy and Environmental Sciences, Stanford (from 2015); Director, Institute for Computational and Mathematical Engineering, Stanford (from 2010); Stanford Fellow (2010-2012); Magne Espedal Professor II, Bergen University (2011-2014); Aldo Leopold Fellow (2009); Chair, SIAM Activity group in Geosciences (2007, present, reelected in 2009); Faculty Research Fellow, Clayman Institute (2008); Elected to Council of Society of Industrial and Applied Mathematics (SIAM) (2007); organizing committee, 2008 Gordon Conference on Flow in Porous Media; producer, Smart Energy podcast channel; Director, Stanford Yacht Research; Co-director and founder, Stanford Center of Excellence for Computational Algorithms in Digital Stewardship; Editor, Journal of Small Craft Technology; Associate editor, Transport in Porous Media; Reviewer for various journals and organizations including SPE, DoE, NSF, Journal of Computational Physics, Journal of Scientific Computing, Transport in Porous Media, Computational Geosciences; member, SIAM, SPE, KIVI, AGU, and APS
Associate Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science
Current Research and Scholarly InterestsMy lab focuses on biomedical data fusion: the development of machine learning methods for biomedical decision support using multi-scale biomedical data. We primarily use methods based on regularized linear regression to accomplish this. We primarily focus on applications in oncology and neuroscience.
Amato J. Giaccia
Jack, Lulu and Sam Willson Professor, Professor of Radiation Oncology, Emeritus
Current Research and Scholarly InterestsDuring the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsThe Giardino Laboratory: our group aims to decipher the neural mechanisms underlying psychiatric conditions of stress, addiction, and sleep disturbances. Our work uses combinatorial technologies for precisely mapping, monitoring, and manipulating neural circuits that drive hedonic and homeostatic states. Projects in the lab are funded by the National Institutes of Health (NIAAA), the Whitehall Foundation, and the Brain Research Foundation.
Assistant Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsGlia make up more than half of the cells in the human brain, but we are just beginning to understand the complex and multifactorial role glia play in health and disease. Glia are decidedly dynamic in form and function. Understanding the mechanisms underlying this dynamic nature of glia is imperative to developing novel therapeutic strategies for diseases of the nervous system that involve aberrant gliogenesis, especially related to changes in myelination.
Professor of Anesthesiology, Perioperative and Pain Medicine, Emerita
Current Research and Scholarly InterestsAstrocytes, microglia and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles. We focus on the cellular and molecular basis of brain cell injury in stroke. We study the effects of altering miRNA expression, altering levels of heat shock and cell death regulatory proteins. Our goal is to improve outcome by improving mitochondrial function and brain cell survival, and reducing oxidative stress and inflammation.