Sarafan ChEM-H


Showing 1-10 of 12 Results

  • Jan Carette

    Jan Carette

    Associate Professor of Microbiology and Immunology

    Current Research and Scholarly InterestsOur research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.

  • Lynette Cegelski

    Lynette Cegelski

    Associate Professor of Chemistry and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsOur research program is inspired by the challenge and importance of elucidating chemical structure and function in complex biological systems and the need for new strategies to treat infectious diseases. The genomics and proteomics revolutions have been enormously successful in generating crucial "parts lists" for biological systems. Yet, for many fascinating systems, formidable challenges exist in building complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell factories. We have introduced uniquely enabling problem-solving approaches integrating solid-state NMR spectroscopy with microscopy and biochemical and biophysical tools to determine atomic- and molecular-level detail in complex macromolecular assemblies and whole cells and biofilms. We are uncovering new chemistry and new chemical structures produced in nature. We identify small molecules that influence bacterial assembly processes and use these in chemical genetics approaches to learn about bacterial cell wall, amyloid and biofilm assembly.

    Translationally, we have launched a collaborative antibacterial drug design program integrating synthesis, chemical biology, and mechanistic biochemistry and biophysics directed at the discovery and development of new antibacterial therapeutics targeting difficult-to-treat bacteria.

  • Ovijit Chaudhuri

    Ovijit Chaudhuri

    Associate Professor of Mechanical Engineering and, by courtesy, of Bioengineering

    Current Research and Scholarly InterestsWe study the physics of cell migration, division, and morphogenesis in 3D, as well cell-matrix mechanotransduction, or the process by which cells sense and respond to mechanical properties of the extracellular matrices. For both these areas, we use engineered biomaterials for 3D culture as artificial extracellular matrices.

  • James K. Chen

    James K. Chen

    Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry

    Current Research and Scholarly InterestsOur laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.

  • Wah Chiu

    Wah Chiu

    Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology

    Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.

  • Danny Hung-Chieh Chou

    Danny Hung-Chieh Chou

    Assistant Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.

  • Jennifer R. Cochran

    Jennifer R. Cochran

    Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsMolecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology

  • Steven M. Corsello

    Steven M. Corsello

    Assistant Professor of Medicine (Oncology) and, by courtesy, of Chemical and Systems Biology

    BioI am a physician scientist and medical oncologist at Stanford University. My laboratory operates at the intersection of functional genomics and chemical biology, with the goal of advancing novel molecular mechanisms of cancer inhibition to clinical use. We aim to 1) leverage phenotypic screening and functional genomics to determine novel anti-cancer mechanisms of small molecules, 2) develop new targeted therapy approaches in gastrointestinal cancer, and 3) build a comprehensive community resource for drug repurposing discovery.

  • Markus Covert

    Markus Covert

    Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsOur focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.