Wu Tsai Neurosciences Institute
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Robert K. Jackler, MD
Edward C. and Amy H. Sewall Professor, Emeritus
Current Research and Scholarly InterestsTobacco advertising - please see below for details
Clinical: Development of innovative surgical methods, via the cranial base, to expose inaccessible intracranial disease. Surgical simulation and robotics. Evidence based outcomes analysis in acoustic neuroma and other tumors of the cerebellopontine angle.
Medical history - especially the history of otology, neurosurgery, deafness, and quackery.
Assistant Professor of Pathology
Current Research and Scholarly InterestsWe identified a common disorder of aging called clonal hematopoiesis of indeterminate potential (CHIP). CHIP occurs due to certain somatic mutations in blood stem cells and represents a precursor state for blood cancer, but is also associated with increased risk of cardiovascular disease and death. We hope to understand more about the biology and clinical implications of CHIP using human and model system studies.
Associate Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly InterestsMy laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.