Wu Tsai Neurosciences Institute
Showing 1-10 of 15 Results
Thomas Rando, MD, PhD
Professor of Neurology
Current Research and Scholarly InterestsOur laboratory studies the molecular mechanisms regulating stem cell function, the effects of aging on skeletal muscle and skeletal muscle stem cells, and the pathogenesis and experimental therapeutics for hereditary muscle diseases, specifically the muscular dystrophies.
Director for Planning and Operations
BioTanya is the Director for Planning and Operations of the Wu Tsai Neurosciences Institute. She has a PhD in Molecular and Cell Biology from UC Berkeley. Prior to joining Wu Tsai, Tanya was the Associate Director of Information Technology for Stanford Bio-X. Tanya was a postdoc with Michael Levitt in the Department of Structural Biology at Stanford, and a graduate student with Susan Marqusee in the Department of Molecular and Cell Biology at UC Berkeley.
Natalie L. Rasgon
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine) at the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Rasgon has been involved in longitudinal placebo-controlled neuroendocrine studies for nearly two decades, and she has been involved in neuroendocrine and brain imaging studies of estrogen effects on depressed menopausal women for the last eight years. It should be noted that in addition to her duties as a Professor of Psychiatry and Obstetrics & Gynecology, Dr. Rasgon is also the Director of the Behavioral Neuroendocrinology Program and of the Women's Wellness Program.
Jennifer L. Raymond
Professor of Neurobiology
Current Research and Scholarly InterestsWe study the neural mechanisms of learning, using a combination of behavioral, neurophysiological, and computational approaches. The model system we use is a form of cerebellum-dependent learning that regulates eye movements.
Lawrence Recht, MD
Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsOur laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.
Richard J. Reimer, MD
Associate Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology at the Palo Alto Veterans Administration Health Care System
Current Research and Scholarly InterestsReimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders.
Allan L. Reiss
Howard C. Robbins Professor of Psychiatry and Behavioral Sciences and Professor of Radiology
Current Research and Scholarly InterestsMy laboratory, the Center for Interdisciplinary Brain Sciences Research (CIBSR), focuses on multi-level scientific study of individuals with typical and atypical brain structure and function. Data are obtained from genetic analyses, structural and functional neuroimaging studies, assessment of endocrinological status, neurobehavioral assessment, and analysis of pertinent environmental factors. Our overarching focus is to model how brain disorders arise and to develop disease-specific treatments.
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.
Associate Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
BioDr. Carolyn Rodriguez utilizes her training as a psychiatrist, neuroscientist, and clinical researcher to innovate rapid-acting treatments to relieve the suffering of patients with severe mental illnesses, including Obsessive-Compulsive Disorder (OCD). She has led landmark clinical trials that pioneered new targeted treatments and investigated the role of glutamatergic and opioid pathways. As the Director of the Translational Therapeutics Lab and Associate Professor in the Department of Psychiatry and Behavioral Science, she developed methods that combine in vivo drug infusions with magnetic resonance spectroscopy (MRS), functional magnetic resonance imaging (fMRI) and electroencephalograpy (EEG) to map human brain circuit dysfunction in real time.
Carolyn is currently engaged in NIH, foundation, and donor funded mechanistic and clinical efficacy studies of glutamate-modulating compounds, non-invasive brain stimulation, and psychotherapy in OCD. Additional studies focus on understanding the brain mechanisms involved in hoarding disorder and how hording behaviors differ from normal collecting. Carolyn also provides mental health care for Veterans as a Consultation-Liaison psychiatrist at the Palo Alto Veterans Affairs.
Carolyn serves as Associate Chair for Inclusion and Diversity in the Department of Psychiatry at Stanford, Deputy Editor of The American Journal of Psychiatry, Vice Chair for the Research Council of the American Psychiatric Association, and Co-Chair of the International OCD Foundation Research Symposium. She has won several national awards, including the Presidential Early Career Award for Scientists and Engineers (PECASE). The PECASE recognizes investigators who are pursuing bold and innovative projects at the early stages of their careers and is considered one of the highest honors in scientific research. Carolyn's research has been highlighted by organizations including NPR, PBS, New York Times, ABC News, NBC News, Newsweek, and Time.com. To educate the public on research findings and resources for clinical care, Carolyn contributes articles to Harvard Business Review and Huffington Post.
Carolyn received her B.S. in Computer Science from Harvard University in 1996, followed by a Ph.D. in Neuroscience and Genetics from Harvard Medical School and an M.D. from Harvard Medical School-M.I.T. in 2004. Born in San Juan, Puerto Rico, she now lives with her husband and 3 children in Palo Alto.