School of Engineering
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John Higgins
Adjunct Professor, Materials Science and Engineering
BioJohn received a BS in biochemistry from Albright College and his Ph.D. in synthetic organic chemistry from Brown University. After completing a Postdoctoral Fellowship at the Sloan-Kettering Cancer Institute in NYC in the departments of Positron Emission Tomography and Neurology, he joined the Medicinal Chemistry Discovery group at Johnson Matthey Biomedical. There he made several significant contributions to early research projects on new Pt- antitumor drugs and peptide-based diagnostic radio-imaging agents. After nearly a decade as a discovery med chemist, he moved on to drug development in positions of increasing responsibility at J&J and Sanofi-Aventis. He and his teams have specialized in the areas of drug delivery, solid state chemistry and biomaterials in relation to improving the bioperformance of therapeutic agents. Towards this end, he has led the successful implementation of a wide range of methodologies into drug discovery space including prodrug design for enhanced solubility/permeability, miniaturized polymeric amorphous dispersions and nanoparticle technologies.
John currently is Executive Director of the Discovery Pharmaceutical Sciences department at Merck’s Discovery Center. In this multidisciplinary role, he is responsible for oversight of the biopharmaceutical and drug delivery aspects of Merck’s discovery programs (small molecules and peptides) as well as the identification of new enabling technologies. Over his over 30 year pharma career, he is co-inventor on 13 US Patents and author of numerous and diverse publications and book chapters in the fields of organic, solid state & medicinal chemistry and drug delivery.
John also currently serves as an Adjunct Associate Professor at the University of Pennsylvania School of Medicine, where he regularly teaches classes in various aspects of drug discovery and development. -
Theodore Terence Ho
Basic Life Research Scientist, Bioengineering
BioHonors & Awards
1. Cum Laude Society, National Cum Laude Society 2008
2. Harvard College Research Program Fellowship, Harvard University 2009-2011
3. 1st Place, Therapeutics Category, University Research and Entrepreneurship Symposium 2011
4. Quantitative Biosciences Consortium Fellowship, University of California San Francisco 2012
5. Honorable Mention, National Science Foundation Graduate Research Fellowship Program 2013
6. Honorable Mention, Ford Foundation Fellowship 2014
7. American Heart Association Fellowship, American Heart Association 2015
8. Best Poster, Bay Area Aging Meeting 2015
9. Hillblom Center for the Biology of Aging Fellowship, Hillblom Center for the Biology of Aging 2016
10. Travel Award Winner, ASCB, Else Kröner-Fresenius, Keystone Symposium NIA Scholarship, ISSCR, Seahorse Bioscience, UCSF 2013-2017
11. Merit Award Winner, International Society for Stem Cell Research 2017
12. Forbes 30 Under 30, Forbes 2019
13. Jane Coffin Childs Fellowship, Jane Coffin Childs Memorial Fund and Howard Hughes Medical Institute 2019
14. Invited speaker, Tedx Middlebury 2019
Professional Education
Bachelor of Arts, Harvard University (2012)
Masters of Science, Harvard University (2012)
Doctor of Philosophy, University of California San Francisco (2017)
Stanford Advisors
Karl Deisseroth, Postdoctoral Faculty Sponsor
Publications
1. Autophagy maintains the metabolism and function of young and old stem cells, Nature 2017 (PubMed ID – 28241143)
2. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions, J Exp Med 2021 (PubMed ID – 34032859)
3. Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing, Nature Cell Biology 2016 (PubMed ID – 27428307)
4. siRNA Delivery Impedes the Temporal Expression of Cytokine-Activated VCAM1 on Endothelial Cells, Annals of biomedical engineering 2016 (PubMed ID – 26101035)
5. Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis, Elife 2015 (PubMed ID – 26193121)
6. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging, Science 2018 (PubMed ID – 29590078)