School of Engineering
Showing 101-150 of 560 Results
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Markus Covert
Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.
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Bruce Daniel
Professor of Radiology (Body Imaging) and, by courtesy, of Bioengineering
Current Research and Scholarly Interests1. MRI of Breast Cancer, particularly new techniques. Currently being explored are techniques including ultra high spatial resolution MRI and contrast-agent-free detection of breast tumors.
2. MRI-guided interventions, especially MRI-compatible remote manipulation and haptics
3. Medical Mixed Reality. Currently being explored are methods of fusing patients and their images to potentially improve breast conserving surgery, and other conditions. -
Karl Deisseroth
D. H. Chen Professor, Professor of Bioengineering and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsKarl Deisseroth's laboratory created and developed optogenetics, hydrogel-tissue chemistry (beginning with CLARITY), and a broad range of enabling methods. He also has employed his technologies to discover the neural cell types and connections that cause adaptive and maladaptive behaviors.
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Scott L. Delp, Ph.D.
Director, Wu Tsai Human Performance Alliance at Stanford, James H. Clark Professor in the School of Engineering, Professor of Bioengineering and of Mechanical Engineering
Current Research and Scholarly InterestsExperimental and computational approaches to study human movement. Development of biomechanical models to analyze muscle function, study movement abnormalities, design medical products, and guide surgery. Imaging and health technology development. Discovering the principles of peak performance to advance human health. Human performance research. Wearable technologies, video motion capture, and machine learning to enable large-scale analysis.
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Gauri Desai
Postdoctoral Scholar, Bioengineering
BioDr. Gauri Desai is a Postdoctoral Research Associate with the Female Athlete Science and Translational Research Program (FASTR). She is a biomechanist, with a research focus on female-specific biomechanical risk factors for sport-related injuries. She integrates biomechanics principles with physiology to provide an all-round perspective on improving performance and mitigating injury risk in female athletes. Dr. Desai's research complements human subject experiments with insights from computer modeling and simulation, to answer research questions that are challenging to address via human subject research studies alone. Beyond research, she is an active contributor to the sports science community through mentorship and advocacy for women in sport.
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Drew Endy
Associate Professor of Bioengineering and Senior Fellow, by courtesy, at the Hoover Institution and at the Freeman Spogli Institute for International Studies
Current Research and Scholarly InterestsWe work to strengthen the foundations and expand the frontiers of synthetic biology. Our foundational work includes (i) advancing reliable reuse of bio-measurements and -materials via standards that enable coordination of labor, and (ii) developing and integrating measurement and modeling tools for representing and analyzing living matter at whole-cell scales. Our work beyond the frontiers of current practice includes (iii) bootstrapping biotechnology tools in unconventional organisms (e.g., mealworms, wood fungus, skin microbes), and (iv) exploring the limits of whole-genome recoding and building cells from scratch. We also support strategy and policy work related to bio-safety, security, economy, equity, justice, and leadership.
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Daniel Bruce Ennis
Professor of Radiology (Veterans Affairs) and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsThe Cardiac MRI Group seeks to invent and validate methods to quantify cardiac performance. We develop methods to measure cardiac structure (DWI/DTI), function (tagging and DENSE), flow (PC-MRI), and remodeling (diffusion, T1-mapping, fat-water mapping) for pediatrics and adults.
Fundamental to our research is a set of tools for numerically optimizing gradient waveforms, Bloch simulations, and patient-specific 3D-printed cardiovascular structures connected to computer controlled flow pumps. -
Jeffrey A. Feinstein, MD, MPH
Dunlevie Family Professor of Pulmonary Vascular Disease and Professor, by courtesy, of Bioengineering
Current Research and Scholarly InterestsResearch interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) the evaluation and treatment of pulmonary hypertension/pulmonary vascular diseases, and (3) development and testing of medical devices/therapies for the treatment of congenital heart disease and pulmonary vascular diseases.
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Michael Fischbach
Liu (Liao) Family Professor
Current Research and Scholarly InterestsThe microbiome carries out extraordinary feats of biology: it produces hundreds of molecules, many of which impact host physiology; modulates immune function potently and specifically; self-organizes biogeographically; and exhibits profound stability in the face of perturbations. Our lab studies the mechanisms of microbiome-host interactions. Our approach is based on two technologies we recently developed: a complex (119-member) defined gut community that serves as an analytically manageable but biologically relevant system for experimentation, and new genetic systems for common species from the microbiome. Using these systems, we investigate mechanisms at the community level and the strain level.
1) Community-level mechanisms. A typical gut microbiome consists of 200-250 bacterial species that span >6 orders of magnitude in relative abundance. As a system, these bacteria carry out extraordinary feats of metabolite consumption and production, elicit a variety of specific immune cell populations, self-organize geographically and metabolically, and exhibit profound resilience against a wide range of perturbations. Yet remarkably little is known about how the community functions as a system. We are exploring this by asking two broad questions: How do groups of organisms work together to influence immune function? What are the mechanisms that govern metabolism and ecology at the 100+ strain scale? Our goal is to learn rules that will enable us to design communities that solve specific therapeutic problems.
2) Strain-level mechanisms. Even though gut and skin colonists live in communities, individual strains can have an extraordinary impact on host biology. We focus on two broad (and partially overlapping) categories:
Immune modulation: Can we redirect colonist-specific T cells against an antigen of interest by expressing it on the surface of a bacterium? How do skin colonists induce high levels of Staphylococcus-specific antibodies in mice and humans?
Abundant microbiome-derived molecules: By constructing single-strain/single-gene knockouts in a complex defined community, we will ask: What are the effects of bacterially produced molecules on host metabolism and immunology? Can the molecular output of low-abundance organisms impact host physiology?
3) Cell and gene therapy. We have begun two new efforts in mammalian cell and gene therapies. First, we are developing methods that enable cell-type specific delivery of genome editing payloads in vivo. We are especially interested in delivery vehicles that are customizable and easy to manufacture. Second, we have begun a comprehensive genome mining effort with an emphasis on understudied or entirely novel enzyme systems with utility in mammalian genome editing. -
Polly Fordyce
Associate Professor of Bioengineering and of Genetics
Current Research and Scholarly InterestsThe Fordyce Lab is focused on developing new instrumentation and assays for making quantitative, systems-scale biophysical measurements of molecular interactions. Current research in the lab is focused on three main platforms: (1) arrays of valved reaction chambers for high-throughput protein expression and characterization, (2) spectrally encoded beads for multiplexed bioassays, and (3) sortable droplets and microwells for single-cell assays.
