School of Medicine
Showing 681-700 of 1,545 Results
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Nasim Sabery Khavari
Clinical Associate Professor, Pediatrics - Gastroenterology
Current Research and Scholarly InterestsPediatric Gastroenterology, Celiac Disease, Nutrition in Celiac Disease
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Joseph Kim
Clinical Professor, Pediatrics
BioJoseph J. Kim, MD is a Clinical Associate Professor of Pediatrics and Emergency Medicine at the Stanford University School of Medicine. Dr. Kim also serves as the Chief of the Division of Pediatric Hospital Medicine at Stanford University and as the Associate Chief Medical Officer of Stanford Children’s Health. Dr. Kim’s career has focused on medical leadership and program building in pediatric hospital medicine. He has been active locally and nationally promoting patient experience, with particular emphasis on family centered care in pediatric inpatient settings. He has participated in numerous local and national care improvement programs including efforts around bronchiolitis, inpatient asthma management, pediatric sedation, medical co-management of surgical patients and patient care progression in inpatient settings. In his hospital administrative roles he has championed safety rounding, family centered rounding, scheduled based care of inpatients, discharge planning and value based performance improvement. Dr. Kim has mentored dozens of trainees and junior faculty in healthcare leadership and program administration.
Dr. Kim received his BA in Sociology from the University of Virginia and his MD from SUNY Upstate Medical University in Syracuse. He completed his residency in pediatrics at the University of California San Francisco. Clinically, Dr. Kim practices as a Pediatric Hospitalist at Lucile Packard Children’s Hospital Stanford and at California Pacific Medical Center. -
Juliann Lipps Kim
Adjunct Clinical Professor, Pediatrics - General Pediatrics
BioDr. Juliann Kim works as a Pediatric Hospitalist for PAMF. She cares for patients in the LPCH Newborn Nursery, Packard Intermediate Care Nursery, and on the inpatient wards. She serves on several LPCH committees including Professional Performance Evaluation Committee, Perinatal Care Committee, Credentials Committee, and Care Improvement Committee. She served as the LPCH Medical Staff President from 2018-2020.
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Seung K. Kim M.D., Ph.D.
KM Mulberry Professor, Professor of Developmental Biology, of Medicine (Endocrinology) and, by courtesy, of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsWe study the development of pancreatic islet cells using molecular, embryologic and genetic methods in several model systems, including mice, pigs, human pancreas, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. These approaches have informed efforts to generate replacement islets from renewable sources for diabetes.
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Yong Yean Kim
Assistant Professor of Pediatrics ( Hematology & Oncology)
BioOur lab is interested in translational science to bring new therapies to clinical trials. In particular, we are interested in pediatric sarcomas which have not had advancement in clinical treatment for decades. Current projects in the lab focus on understanding of the biology of fusion transcription factor PAX3::FOXO1 which is the driver mutation in fusion positive rhabdomyosarcoma. PAX3::FOXO1 is a powerful oncogenic transcription factor which rewires the transcriptional organization to lock the cancer cell in the proliferative state. Since transcription factors including PAX3::FOXO1 are difficult to target using small molecules, we aim to understand how PAX3::FOXO1 is regulated and targeting the regulators of PAX3::FOXO1. By understanding and targeting the regulation of PAX3::FOXO1, we hope to bring new therapies for fusion positive rhabdomyosarcoma. Additionally, these regulatory mechanisms may also be active in other transcription driven cancers such as the EWSR1::FLI1 driven Ewings Sarcoma.
Our lab is also interested in exploring the epigenetic landscape of pediatric solid tumors and trying to understand how dysregulation in the epigenome drives oncogenesis. We utilize various CRISPR mediated genetic techniques to interrogate the regulators of epigenome focusing on the histone lysine demethylases (KDMs). KDMs are an understudied group of epigenetic regulators which can be targeted for therapeutic effect. We explore the role of KDMs in pediatric solid tumors and hope to identify potential targets for drug development.
