Genetics
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Jesse Engreitz
Assistant Professor of Genetics
Current Research and Scholarly InterestsRegulatory elements in the human genome harbor thousands of genetic risk variants for common diseases and could reveal targets for therapeutics — if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body.
We combine experimental and computational genomics, biochemistry, molecular biology, and genetics to assemble regulatory maps of the human genome and uncover biological mechanisms of disease. -
Rongxin Fang
Assistant Professor of Neurosurgery and, by courtesy, of Genetics
BioRongxin Fang received his Ph.D. in Bioinformatics and Systems Biology from the University of California, San Diego, under the mentorship of Bing Ren (2015–2019). During his doctoral training, he developed high-throughput genomic technologies and computational tools to map the structure and activity of the mammalian genome at large scale and single-cell resolution. He then applied these approaches to investigate how cis-regulatory elements - such as enhancers - control gene expression and drive the diverse transcriptional programs underlying cellular diversity in the mammalian brain. As an HHMI–Damon Runyon Postdoctoral Fellow at Harvard University (2019–2024), he worked with Xiaowei Zhuang. Rongxin developed and applied genome-scale, volumetric 3D transcriptome imaging methods to map the molecular and cellular architecture of the mammalian brain across evolution and aging. He also contributed to the collaboration with Adam Cohen and Catherine Dulac to integrate transcriptome imaging with functional neuronal imaging, identifying neuronal populations in the animal brain that underlie specific brain functions.
