Maternal & Child Health Research Institute (MCHRI)
Showing 191-200 of 215 Results
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熊剑 (Jian Xiong)
Postdoctoral Scholar, Chemical Engineering
BioI thrive to understand the roles of lysosomes in physiological and pathological conditions. Lysosomes are both degradation compartment and metabolic controlling hub, and dysregulation of lysosomal functions are frequently implicated in a vast number of diseases including neurodegenerative diseases, however, the systematic knowledge of the molecular mechanism by which lysosomal contributes to these diseases is lacking. Ion channels are the primary mediators of neuronal activity, defects in neuronal ion channel activity are linked with many kinds of neurodegenerative diseases. Interestingly, besides typical ion channels that are involved in the neuronal activity, defects in lysosomal ion channels, such as TRPML1, CLN7 and CLC-7 are also implicated in neuropathy. My previous work as Ph.D student in University of Texas MD Anderson Cancer Center focused on regulation of lysosomal function by ion channels and metabolites. I discovered a mechanism of lysosomal Na+ channel regulate mTORC1 activation by regulating lysosomal amino acid accumulation. I also discovered role of glutamine in controlling lysosomal degradation capacity. In the meantime, I developed novel methods to isolate organelles. My ultimate research goal is to understand the key developmental pathways and how alterations in gene sequences and expression contribute to human disease, therefore, I am pursuing independent academic researcher as my career goal. Starting Feb 2022, I work with Dr. Monther Abu-Remaileh at Stanford University on role of lysosomes in neurodegenerative diseases. I use genetics, chemical biology and omics approaches to study lysosome function under various physiological and pathological conditions, especially age-associated neurodegenerative disorders, and monogenic neurodegenerative lysosome storage diseases. In Stanford, I aim to integrate ionic regulation, metabolomic regulation and functional proteomic regulation to systematically understand the biology of lysosome in physiological conditions and pathological conditions.
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Liu Yang
Postdoctoral Scholar, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy current focus lies in analyzing bedside monitoring waveforms and electronic health record data to understand their correlations with adverse conditions in premature infants, and to explore effective solutions that can enhance the outcomes for these vulnerable patients.
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Pourya Yarahmadi, MD
Postdoctoral Scholar, Cardiovascular Institute
BioI earned my medical degree from Tehran University of Medical Sciences and currently work as a postdoctoral researcher in Dr. Nguyen’s laboratory. My research focuses on understanding how the immune system contributes to cardiovascular disease, particularly atherosclerosis. Using advanced technologies such as single-cell RNA sequencing, I investigate the complex interactions between immune cells and the vascular system. Outside of research, I enjoy playing soccer, working out, hiking, and spending time with friends.
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Marwa Zafarullah
Postdoctoral Scholar, Neurology and Neurological Sciences
BioDr. Marwa Zafarullah is a dedicated neuroscientist with extensive interdisciplinary experience spanning over 8 years in clinical and pre-clinical research. She holds a Ph.D. in Integrative Genetics and Genomics (IGG) from the University of California Davis, focusing on neuroscience, human genetics, and functional genomics. Before joining Stanford, Dr. Zafarullah harnessed the power of molecular biology with advanced technologies to delve into biomarkers related to the prediction, development, progression, and severity of Fragile X Syndrome and associated disorders.
Dr. Zafarullah's career journey reflects her commitment to advancing scientific knowledge, improving patient care, and positively impacting society through her research and contributions. She thrives in multi-disciplinary teams, aiming to enhance the quality of life for all individuals affected by various neurological conditions. Beyond her professional endeavors, she enjoys communicating complex scientific concepts to diverse audiences. Her continuous pursuit of excellence and her drive to bridge clinical practice and scientific innovation make her a true trailblazer in the field.
