Maternal & Child Health Research Institute (MCHRI)
Showing 51-70 of 70 Results
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Juliet Klasing Knowles
Assistant Professor of Neurology and Neurological Sciences (Pediatric Neurology) and of Pediatrics
Current Research and Scholarly InterestsThe Knowles lab studies how white matter structure changes in different forms of epilepsy, and how aberrant white matter structure, in turn, shapes neuronal network function. In mouse models, we use a variety of innovative tools including neurophysiology, quantitative EEG, behavior, histological measures of white matter structure and MR imaging. We also conduct clinical research to study white matter abnormalities in children with epilepsy.
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Justin M Ko, MD, MBA
Clinical Professor, Dermatology
BioJustin Ko joined Stanford Medicine in 2012. He is a Clinical Professor and Associate Chair of Clinical Affairs in the Department of Dermatology and Chief of Dermatology at Stanford Healthcare where he spearheads the dermatology department's clinical enterprise including efforts around digital health, network development, quality and value-based care. He also holds health system leadership roles within Stanford Medicine including as Associate Chief Quality Officer and physician lead of Patient Experience and Ambulatory Access. Justin is a clinical expert in skin cancer and melanoma as well as alopecia areata and hair loss disorders, and is a leader and researcher in the areas of care delivery innovation and Artificial/Augmented Intelligence.
His passion for melanoma, early cancer detection, and improving care delivery drives his efforts and research around leveraging advances in machine learning and artificial intelligence to increase the breadth of populations that can be reached. He developed and runs a digital care delivery program at SHC, providing virtual visits for patients and remote consultations for referring clinicians. He conducts research on and engages in collaborations around interventions that layer advances in machine learning on digital health capabilities to enhance access, quality and value of dermatologic care and is a co-founder and co-leader of the Stanford Translational AI in Dermatology (TRAIND) group. He co-founded and chaired the American Academy of Dermatology's (AAD) Committee on Augmented Intelligence and has served as chair of the AAD's Health Information Technology Committee.
Dr. Ko has also been driven to find new treatments for alopecia areata, an immune-mediated condition that can progress to total hair loss through various clinical trials and translational research efforts. He sits on the clinical research advisory board of the National Alopecia Areata Foundation and is a co-founder of the Skin Innovation and Interventional Research Group (SIIRG) which conducts clinical and translational research on skin disease.
He graduated magna cum laude from Harvard University and worked in investment banking; mergers and acquisitions at JP Morgan before going on to earn a combined medical and business degree at Tufts University. During medical school, he was a member of the Alpha Omega Alpha honor society. Dr. Ko then performed his residency at the Harvard Dermatology Residency Training Program where he served as chief resident. -
Brian Kobilka
Hélène Irwin Fagan Chair of Cardiology
Current Research and Scholarly InterestsStructure, function and physiology of adrenergic receptors.
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Eric Kool
George A. and Hilda M. Daubert Professor of Chemistry
Current Research and Scholarly Interests• Design of cell-permeable reagents for profiling, modifying, and controlling RNAs
• Developing fluorescent probes of DNA repair pathways, with applications in cancer, aging, and neurodegenerative disease
• Discovery and development of small-molecule modulators of DNA repair enzymes, with focus on cancer and inflammation -
Ron Kopito
Professor of Biology
Current Research and Scholarly InterestsOur laboratory use state-of-the-art cell biological, genetic and systems-level approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system.
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Izabela Kowalczyk
Postdoctoral Scholar, Developmental Biology
BioDr. Izabela Kowalczyk is a postdoctoral fellow in the laboratory of Dr. Sarah Bowling, Department of Developmental Biology. She is studying embryonic development, with a focus on heart valve formation and the influence of the maternal environment on this process. Dr. Kowalczyk completed her Ph.D. at the Max-Delbrück-Center for Molecular Medicine in Berlin, under the supervision of Dr. Annette Hammes, where she investigated cell and tissue morphogenesis during early forebrain development. Her work identified novel components of Sonic Hedgehog (SHH) signaling and primary cilia biology, providing new insights into the variable penetrance of holoprosencephaly in mouse models.
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Sheri Krams
Senior Associate Dean, Graduate Education and Postdoctoral Affairs and Professor of Surgery (Abdominal Transplantation)
Current Research and Scholarly InterestsResearch Interests: 1) NK Cell Responses to EBV, 2) Exosomes in Immune Responses, 3) Plasmacytoid Dendritic Cell-Mediated Graft Prolongation, 4)Transplant Immunology
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Elliot J. Krane
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric Anesthesia) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsThe management of pain in children using intraspinal opioids, regional anesthetics, and novel analgesic agents; cerebral and osmolar complications of diabetic ketoacidosis in children.
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Mark Krasnow
Paul and Mildred Berg Professor
Current Research and Scholarly Interests- Lung development and stem cells
- Neural circuits of breathing and speaking
- Lung diseases including lung cancer
- New genetic model organism for biology, behavior, health and conservation -
Emily Kraus
Clinical Assistant Professor, Orthopaedic Surgery
BioDr. Kraus is a Clinical Assistant Professor at Stanford Children’s Orthopedic and Sports Medicine Center trained in the specialty of Physical Medicine and Rehabilitation (PM&R) sports medicine. She has research and clinical interests in endurance sports medicine, injury prevention, running biomechanics, prevention of bone stress injuries, and the promotion of health and wellness at any age of life. Dr. Kraus is the director of the FASTR Program, which stands for Female Athlete Science and Translational Research. The FASTR program is supported by the Wu Tsai Human Performance Alliance and seeks to close the gender gap in sports science research with an emphasis on early identification and interventions to prevent injury and identify ways to optimize performance in female athletes. Dr. Kraus is also a member of the U.S. Olympic and Paralympic Committee Women's Health Task Force and is the medical director of the Stanford Children's Motion Analysis and Sport Performance Lab. She has completed nine marathons including the Boston Marathon twice and one 50k ultramarathon. With running and staying physically active as one of her personal passions, she recognizes the importance of fitness for overall wellbeing and the prevention of chronic medical conditions.
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Thomas M. Krummel, MD, FACS/FAAP
Emile Holman Professor, Emeritus
Current Research and Scholarly InterestsSurgical Innovation, Simulation and Virtual Reality in Surgical Education, Fetal Healing-Cellular and Biochemical Mechanisms
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Manoj Kumar
Postdoctoral Scholar, Radiology
Current Research and Scholarly InterestsAntibody discovery and characterization | Targeted delivery of genes and drugs | mRNA
therapeutics | Immuno-oncology | CAR-T engineering | Immune profiling | PET/MR imaging -
Anshul Kundaje
Associate Professor of Genetics and of Computer Science
Current Research and Scholarly InterestsWe develop statistical and machine learning frameworks to model gene regulation and decipher the genetic and molecular basis of disease
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu). -
Clete A. Kushida, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Kushida is a neurologist and sleep specialist who directs several NIH- and industry-sponsored research studies, focused on topics such as the physical features and neurocognitive changes associated with the obstructive sleep apnea syndrome, the epidemiology and treatment of restless legs syndrome/periodic limb movement disorder, primary care sleep education and training, and countermeasures for sleep loss.
