Pediatrics
Showing 711-720 of 1,612 Results
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Nasim Sabery Khavari
Clinical Associate Professor, Pediatrics - Gastroenterology
Current Research and Scholarly InterestsPediatric Gastroenterology, Celiac Disease, Nutrition in Celiac Disease
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Hyunkyung Claire Kim
Postdoctoral Scholar, Endocrinology and Metabolism
BioHyunkyung Claire Kim is a Postdoctoral Research Scholar in the Translational Genomics of Diabetes Lab led by Dr. Anna Gloyn. She received her PhD in Genetics from the University of Chicago, where she developed a statistical method to disentangle shared and trait-specific genetic architecture across complex diseases using large-scale biobank data. Prior to her doctoral training, she worked at Massachusetts General Hospital, studying the genetic subtypes and heterogeneity of type 2 diabetes through data-driven clustering approaches.
She is interested in the translational genomics of diabetes, including integrating human genetics with clinical data to uncover disease mechanisms and advance precision medicine. Her long-term research interests include developing computational methods to understand how genetic, molecular, and environmental factors jointly shape metabolic disease risk, disease heterogeneity, and progression.
