School of Medicine
Showing 1,341-1,360 of 5,184 Results
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James Ferrell
Professor of Chemical and Systems Biology and of Biochemistry
Current Research and Scholarly InterestsMy lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.
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Margaret S. Ferris, MD
Clinical Assistant Professor, Adult Neurology
BioDr. Ferris is a fellowship-trained neurologist and Clinical Assistant Professor in the Department of Neurology, Division of Movement Disorders.
She diagnoses and treats a breath of movement disorders such as Parkinson’s disease and essential tremor. She recognizes the broad effects of these conditions on daily living and aims to develop personalized, comprehensive treatment plans that optimize health and quality of life.
Dr. Ferris research interests focus on access to interventional therapies for movement disorders. She has participated in investigations sponsored by the National Institutes of to evaluate advanced treatments for complications of Parkinson’s disease.
She has co-authored articles in publications such as Nature, The Neurohospitalist, and BioMed Central (BMC) Genomics. She has presented her insights about innovations in the understanding, detection, and management of movement disorders at conferences including, the Society for Neuroscience Annual Meeting, Pan American Parkinson’s Disease and Movement Disorders Congress.
She is a member of the American Academy of Neurology and the Movement Disorder Society.
Essential tremor patient story: https://www.youtube.com/watch?v=fV6BzyU9b3c -
Dorien Feyaerts
Instructor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsBiomedical scientist and immunologist with a strong background in fetal-maternal immunology that aims to conduct impactful translational research in women’s health to improve the health of mothers and their children.
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Vikram Fielding-Singh, MD, JD, MS
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsImproving perioperative care of patients with end stage kidney disease, using biomarkers to aid early diagnosis of acute kidney injury, and evaluating the performance of risk prediction models in perioperative medicine.
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Andrey Finegersh, MD, PhD
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Finegersh is a fellowship-trained head and neck surgical oncologist with board certification in otolaryngology and an Assistant Professor with the Stanford School of Medicine Department of Otolaryngology.
He specializes in treatment of benign and malignant tumors of the head and neck and has received additional training in microvascular reconstruction and transoral robotic surgery. He takes tremendous pride in providing compassionate care for patients and managing challenging diagnoses.
Dr. Finegersh completed his MD and PhD degrees at the University of Pittsburgh School of Medicine's combined Medical Scientist Training Program. He went on to complete residency in otolaryngology at the University of California San Diego (UCSD) and his fellowship at Stanford University, where he stayed on as faculty.
He has extensive research experience in head and neck cancer epigenetics and completed post-doctoral research at the University of Pittsburgh and UCSD. He has received grants from the NIH and American Academy of Otolaryngology and has an active research lab studying molecular mechanisms of cancer. Dr. Finegersh has additional clinical interests in studying the role of minimally invasive surgery to improve outcomes for head and neck cancer patients. -
Anna Finley Caulfield, MD
Clinical Professor, Adult Neurology
Current Research and Scholarly InterestsDr. Finley joined the Stanford Stroke Center in 2004 from Beth Israel Deaconess Medical Center in Boston. She cares for acute stroke patients and other neurologically critical ill patients in the intensive care unit. Currently, her research interests include hypothermia after cardiac arrest and comparing health care provider's predications of future neurological function in neurologically critical ill patients to their 6-month outcome.
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David Fiorentino, MD, PhD
Professor of Dermatology
Current Research and Scholarly InterestsFrom a clinical standpoint, I am particularly focused in the care of patients with myositis or systemic sclerosis. We offer clinical trials, including novel, cutting-edge cellular-based (e.g. chimeric antigen receptor, or, CAR T) therapies for these diseases. We are particularly interested in understanding the role of auto antigens in providing windows into disease pathogenesis, as well as their potential direct role of autoantibodies in causing disease.
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Andrew Fire
George D. Smith Professor of Molecular and Genetic Medicine and Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWhile chromosomal inheritance provides cells with one means for keeping and transmitting genetic information, numerous other mechanisms have (and remain to be) discovered. We study novel cellular mechanisms that enforce genetic constancy and permit genetic change. Underlying our studies are questions of the diversity of inheritance mechanisms, how cells distinguish such mechanisms as "wanted" versus "unwanted", and of the consequences and applications of such mechanisms in health and disease.
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Michael Fischbach
Liu (Liao) Family Professor
Current Research and Scholarly InterestsThe microbiome carries out extraordinary feats of biology: it produces hundreds of molecules, many of which impact host physiology; modulates immune function potently and specifically; self-organizes biogeographically; and exhibits profound stability in the face of perturbations. Our lab studies the mechanisms of microbiome-host interactions. Our approach is based on two technologies we recently developed: a complex (119-member) defined gut community that serves as an analytically manageable but biologically relevant system for experimentation, and new genetic systems for common species from the microbiome. Using these systems, we investigate mechanisms at the community level and the strain level.
1) Community-level mechanisms. A typical gut microbiome consists of 200-250 bacterial species that span >6 orders of magnitude in relative abundance. As a system, these bacteria carry out extraordinary feats of metabolite consumption and production, elicit a variety of specific immune cell populations, self-organize geographically and metabolically, and exhibit profound resilience against a wide range of perturbations. Yet remarkably little is known about how the community functions as a system. We are exploring this by asking two broad questions: How do groups of organisms work together to influence immune function? What are the mechanisms that govern metabolism and ecology at the 100+ strain scale? Our goal is to learn rules that will enable us to design communities that solve specific therapeutic problems.
2) Strain-level mechanisms. Even though gut and skin colonists live in communities, individual strains can have an extraordinary impact on host biology. We focus on two broad (and partially overlapping) categories:
Immune modulation: Can we redirect colonist-specific T cells against an antigen of interest by expressing it on the surface of a bacterium? How do skin colonists induce high levels of Staphylococcus-specific antibodies in mice and humans?
Abundant microbiome-derived molecules: By constructing single-strain/single-gene knockouts in a complex defined community, we will ask: What are the effects of bacterially produced molecules on host metabolism and immunology? Can the molecular output of low-abundance organisms impact host physiology?
3) Cell and gene therapy. We have begun two new efforts in mammalian cell and gene therapies. First, we are developing methods that enable cell-type specific delivery of genome editing payloads in vivo. We are especially interested in delivery vehicles that are customizable and easy to manufacture. Second, we have begun a comprehensive genome mining effort with an emphasis on understudied or entirely novel enzyme systems with utility in mammalian genome editing. -
Michael Fischbein
Thelma and Henry Doelger Professor of Cardiovascular Surgery
Current Research and Scholarly InterestsMolecular and genetic mechanisms of aortic aneurysm/dissection development. Molecular mechanisms of aneurysm formation in Marfan Syndrome. Clinical research interests include thoracic aortic diseases (aneurysms, dissections).
