School of Medicine
Showing 21-30 of 71 Results
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Maharshi Krishna Deb
Member, Maternal & Child Health Research Institute (MCHRI)
Current Research and Scholarly InterestsI aim to gain insights of the molecular underpinnings that are critical for the specification of human germ cells as well as the episode of epigenetic reprogramming that they undergo which is critical for their development and thereby essential for perpetual propagation of human species. Under co-mentorship of Prof. Azim Surani and Dr. Shiv Grewal,I aim to learn these lessons from this immortal lineage of human germline to identify interventions against various pediatric as well as degenerative
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Dr. Qiwen Deng
Postdoctoral Scholar, Pathology
BioHow fibroblasts participate in the organ fibrosis and whether targeting fibroblasts is a good strategy to reverse fibrosis is still a mystery. We have identified two important immune checkpoints, CD47 and PD-L1, are highly expressed in fibroblasts and blocking CD47 and PD-L1 reversed lung fibrosis. This is a prove of concept that targeting immune regulatory pathways could be an effective therapeutic approach to treat fibrotic diseases. In addition to identifying novel targets for the treatment of fibrosis, I am also interested in the crosstalk between fibroblasts and innate immune cells in the development of fibrosis. Combined with cutting-edge NGS approaches including single cell sequencing, spatial transcriptomics and high-dimensional CyTOF technique, we have identified several potential targets and characterized immune cells landscape in lung fibrosis. In the long run, I will focus on the validation of these targets. Specifically, I will apply gain- and loss-function approaches to investigate their role in fibrosis in vitro and in vivo.
