School of Medicine
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Pauline Brochet
Postdoctoral Scholar, Biomedical Informatics
BioPauline Brochet is a French scientist from Souraide, France. She completed her undergraduate studies in Molecular, Cellular and Physiological Biology (BSc, Université Clermont-Auvergne) and earned a Master's degree in Software Development and Data Analysis (MSc, Aix-Marseille Université). Pauline pursued a PhD at TAGC (Theories and Approaches for Genomic Complexity) in Marseille, France.
Under the supervision of Dr. Christophe Chevillard and Dr. Lionel Spinelli, Pauline integrated multi-omics data from human heart tissue to investigate the pathogenic processes associated with Chagas Disease Cardiomyopathy (CCC). Notably, she contributed to the development of ChagasDB, the first database associating key features with the different stages of Chagas disease. Her research identified the involvement of mitochondrial DNA mutations, non-coding RNA, transcription factors, and DNA methylation in various pathogenic processes, all leading to the progression of CCC.
Currently, at Stanford University, under the guidance of Dr. Matthew Wheeler and Dr. Daniel Katz, Pauline is conducting postdoctoral research on multi-omics data analysis as part of the Molecular Transducers of Physical Activity Consortium (MoTrPAC). Her work focuses on identifying key covariable features associated with physical exercise, with the ultimate goal of discovering exercise-mimetic drugs that could help prevent heart diseases.
