School of Medicine
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Connor Galen O'Brien
Postdoctoral Medical Fellow, Cardiovascular Medicine
BioDr. O'Brien is a native of Menlo Park, CA. He attended medical school at Columbia University College of Physicians and Surgeons. At Columbia he was elected to both Alpha Omega Alpha and Gold Humanism Honors Societies. He completed an Internal Medicine residency as well as fellowship in Cardiovascular Medicine at Stanford University. In his third year of fellowship, he was selected Chief Cardiology Fellow.
He is currently a post-doctoral fellow performing regenerative medicine research, specifically studying the role of exosomes in treating cardiomyopathy. In addition to his basic science research, he is also involved in human clinical trials investigating the role of stem cells in treating various forms of cardiomyopathy. -
Sean J. O'Sullivan
Postdoctoral Scholar, Psychiatry
BioDr. Sean J. O’Sullivan is an MD/PhD postdoctoral scholar from Philadelphia. His PhD in neuroscience from Thomas Jefferson University focused on the molecular mechanisms of alcohol and opioid withdrawal.
Specifically, he took a systems neuroscience approach to understand the role of the gut microbiome in influencing the negative physical and emotional states that characterize alcohol and opioid withdrawal syndromes.
This work led to the generation of a novel hypothesis—interoceptive neuroinflammatory signaling involving gut dysbiosis and peripheral network decompensation secondary to abstinence in the context of allostasis drives neuroinflammation in the nucleus tractus solitarius (NTS) and amygdala during alcohol and opioid withdrawal which increases the severity of the withdrawal symptoms. He further conjectures that this interoceptive signaling constitutes an antireward pathway that motivates substance dependence via negative reinforcement.
He also investigated neuronal subphenotypes in the suprachiasmatic nucleus which is the principle circadian brain region. He further investigated how circadian rhythms affect gene expression in the NTS and amygdala.
In the Stanford Brain Stimulation Lab, Dr. O’Sullivan is part of the inpatient treatment team that is applying an accelerated transcranial magnetic stimulation (TMS) protocol (Stanford Accelerated Intelligent Neuromodulation Therapy [SAINT]) to hospitalized psychiatric patients. TMS is not currently available to psychiatric inpatients, and this work aims to make this innovative treatment available to those most in need. He is also leading a study researching the effects of TMS on a peripheral biomarker of depression known as L-acetyl-carnitine. He is in the process of applying for psychiatry residency and plans to integrate brain stimulation into his future clinical practice. -
Matthew Raymond Olm
Postdoctoral Scholar, Microbiology and Immunology
BioI am a bioinformatician and microbiologist interested in studying the human microbiome and fine-scale microbial population genetics. See my personal website for more info- https://mrolm.github.io/
