School of Medicine
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Thomas Rando, MD, PhD
Professor of NeurologyOn Leave from 10/01/2021 To 09/30/2023
Current Research and Scholarly InterestsOur laboratory studies the molecular mechanisms regulating stem cell function, the effects of aging on skeletal muscle and skeletal muscle stem cells, and the pathogenesis and experimental therapeutics for hereditary muscle diseases, specifically the muscular dystrophies.
Clinical Associate Professor, Pediatrics - Critical Care
Clinical Associate Professor (By courtesy), Neurology & Neurological Sciences
Current Research and Scholarly InterestsMy research interests reside in the field of Neurocritical Care Medicine. My research focus has included inflammation following traumatic brain injury, outcome prediction after cardiac arrest, and neuro-monitoring in the pediatric intensive care setting. These interests are integrated clinically to focus on the merging of specialized neurologic monitoring and care with prognostic efforts in critically ill patients.
Babak Razavi, MD, PhD
Clinical Assistant Professor, Neurology & Neurological Sciences
BioDr. Razavi's clinical interests are in medically refractory epilepsies and using high density EEG (electroencephalogram) for better localization of seizure foci. His research areas include using advanced digital signal processing and engineering techniques for analyzing EEG and using seizures as a model for understanding consciousness.
Dr. Razavi is the Director of DEL - Distributed EEG Lab. DEL's vision is to make EEG easy as 1, 2, 3. We turn complexity into simplicity. We are distributed in time and space. DEL was founded in the spirit of cloud computing, networking, and the notion that research in collaboration is more exciting and fruitful than in isolation. Everyone contributes - no matter how small; everyone wins - no matter how big. It was inspired by the mentorship of Dr. Kimford Meador and Dr. Robert Fisher. All you need is access to a computer and the internet.
DEL is the ideal collaborative environment for students (undergraduate and graduate) and faculty who would like to: (1) apply ready-to-use advanced analytical techniques to test specific hypotheses in cognition, neuroscience and epilepsy, and (2) develop and test new algorithms for analyzing EEG and other biological signals.
Lawrence Recht, MD
Professor of Neurology and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsOur laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.
Richard J. Reimer, MD
Associate Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsReimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders.