School of Medicine
Showing 221-240 of 586 Results
-
Richard J. Reimer, MD
Associate Professor of Neurology and Neurological Sciences (Adult Neurology)
Current Research and Scholarly InterestsReimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders. -
Navi Reiners, MD, MPH
Adjunct Clinical Assistant Professor, Obstetrics & Gynecology - General
BioDr. Navi Reiners is board certified in Obstetrics and Gynecology. She is dedicated to providing comprehensive obstetrical and gynecological care to women of all ages in a compassionate and patient-centered manner. Her clinical interests include health education and wellness, pregnancy, adolescent health, contraception and minimally invasive surgery. When she is not taking care of patients, she enjoys reading, baking, Pilates and exploring her native Bay Area with her husband and young children.
-
Olaf Reinhartz
Associate Professor of Cardiothoracic Surgery
Current Research and Scholarly Interests1. Mechanical circulatory support in failing Fontan circulation
2. Pathophysiologic response to fetal cardiac surgery.
3. Various clinical projects in pediatric cardiothoracic surgery -
Eduardo Pontes Reis
Postdoc Res Affiliate, Rad/Pediatric Radiology
BioI'm a visiting scholar at Stanford AIMI Center, working in the intersection of Artificial Intelligence and Medicine. My purpose is to contribute to our understanding of intelligence. And our best chance to achieve this is through AI.
Research highlights:
- Published BRAX, the Brazilian Chest X-ray Dataset - https://www.nature.com/articles/s41597-022-01608-8
- Open-sourced the PyTorch implementation of ConVIRT (Y Zhang et al), a contrastive learning method for radiologic images and text (before CLIP) - https://github.com/edreisMD/ConVIRT-pytorch
- Released Brain Hemorrhage Annotations - Brain Hemorrhage Extended - BHX (https://physionet.org/content/bhx-brain-bounding-box)
At Hospital Israelita Albert Einstein:
- Started the Health Story project, a medical history timeline to support research and a more personalized clinical practice
- Ran the development of AI algorithms for diseases of national importance: Tuberculosis, COVID, Melanoma and Head CT -
Allan L. Reiss
Howard C. Robbins Professor of Psychiatry and Behavioral Sciences and Professor of Radiology
Current Research and Scholarly InterestsMy laboratory, the Center for Interdisciplinary Brain Sciences Research (CIBSR), focuses on multi-level scientific study of individuals with typical and atypical brain structure and function. Data are obtained from genetic analyses, structural and functional neuroimaging studies, assessment of endocrinological status, neurobehavioral assessment, and analysis of pertinent environmental factors. Our overarching focus is to model how brain disorders arise and to develop disease-specific treatments.
-
Bruce A Reitz
Norman E. Shumway Professor, Emeritus
Current Research and Scholarly InterestsMechanism of allograft rejection for the heart and, lung; late chronic effects of rejection, such as graft coronary, atherosclerosis in the heart and bronchiolitis obliterans in the, lung; treatment of rejection, including pharmacologic agents, total, lymphoid irradiation, and the induction of tolerance in fetal, animals; clinical studies include the results of lung and heart-lung, transplantation, modification of immunosuppressive protocols, and, factors contributing to late chronic rejection.
-
David A. Relman
Thomas C. and Joan M. Merigan Professor and Professor of Microbiology and Immunology
Current Research and Scholarly InterestsMy investigative program focuses on human-microbe interactions and human microbial ecology, and primarily concerns the ecology of human indigenous microbial communities; a secondary interest concerns the classification of humans with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns and pther aspects of the host response.
