School of Medicine
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Elaine and John Chambers Professor of Pediatric Cancer and Professor of GeneticsOn Partial Leave from 05/30/2022 To 08/28/2022
Current Research and Scholarly InterestsWe investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.
Kathleen M. Sakamoto
Shelagh Galligan Professor in the School of Medicine
Current Research and Scholarly InterestsMy research focuses on the molecular pathways that regulate normal and aberrant blood cell development, including acute leukemia and bone marrow failure syndromes. We are also studying novel drugs for treatment of cancer.
Ece Canan Sayitoglu
Postdoctoral Scholar, Stem Cell Transplantation
BioExperienced Postdoctoral Researcher with a demonstrated history of working with genetically modified immune cells. Skilled in Genome Editing/Crispr, Multi-color Flow Cytometry, Molecular Biology, Cell Culture and Immunotherapy.
Clinical Assistant Professor, Pediatrics - Hematology & Oncology
BioI am currently postdoctoral research fellow pursuing immunotherapy research in the oncology department at Stanford University. My clinical training as a pediatric hematology oncology fellow at Memorial Sloan Kettering Cancer Center highlighted the desperate need for novel therapeutic options for a subtype of aggressive pediatric leukemia, Acute Myeloid Leukemia (AML). Despite our best standard of care for AML, long term survival rates range from 50-60% with an unacceptably high relapse rate of 40%. The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. In parallel to my clinical training, I constructed an AML specific CAR and demonstrated its ability to redirect T cell function mediating eradication of AML cells. As the field of CAR therapy rapidly advances, novel methods to optimize this therapeutic modality are imperative. To this end, supported by research demonstrating superior antitumor function of naïve derived effector T cells compared to central memory derived effector T cells, I am investigating whether preferential modification of naïve T cells to express CARs will generate a T cell subpopulation with increased efficacy. Consolidating my clinical and research experiences within highly academic institutes allows me to synthesize my pursuit of scientific rigor and commitment to the field of oncology, with a mission to achieve productive research and translatable results.
Mona D. Shah, MD, MBA
Adjunct Clinical Associate Professor, Pediatrics - Hematology & Oncology
BioMona is a pediatric hematologist-oncologist, who earned her MD degree at the University of Maryland in 2001. She completed both her categorical pediatric and global health residencies in 2004, followed by a pediatric hematology-oncology fellowship in 2007. She earned her MS in Clinical Investigation as part of the Clinical Scientist Training Program at Baylor College of Medicine in 2011, and more recently, completed an Executive MBA at Rice University’s Jones School of Business in 2018.
Mona was an Associate Professor at Baylor College of Medicine (2007 - 2020) in both Pediatrics and Medicine, local site PI on a number of pediatric hemostasis/thrombosis clinical trials, and spent 10 years as an Associate Medical Director of clinical operations, quality, and safety at Texas Children’s Hospital, Houston, TX.
Mona joined Genentech (a member of Roche Group)’s Rare Blood Disorders Franchise (Product Development - Oncology-Hematology) in February 2020, now as Lead Medical Director, and currently serves as Medical Monitor for the COMMUTE-a and COMMUTE-p Phase III clinical trials (crovalimab in atypical hemolytic uremic syndrome, aHUS). She is also engaged with the Renal Franchise (I2O) in developing crovalimab in Lupus Nephritis (Phase I & II clinical trials in development), and with Human Factors/Pediatric Formulations Working Group on autoinjector devices and oral formulations. Since May 2022, Mona is spending 25% of her time with Early Development Safety (EDS) on a one year rotation. She is based in South San Francisco, CA, and will be working closely with both EDS gRED (Oncology and OMNI) teams.
Mona has kept a bucket list since she was 7 years old (keeps growing): Running wild bouldering/rock climbing as a child in the Shenandoah/Blue Ridge Mountains, swimming with dolphins/piranhas in the Amazon, climbing inside a volcano caldera in Iceland, snorkeling the Great Barrier Reef ... have passport/will travel!
Since July 2022, she has joined Stanford University School of Medicine, as an Adjunct Clinical Associate Professor in the Department of Pediatrics, Division of Hematology-Oncology. Mona enjoys free time in her new home base near San Francisco, where she hosts her visiting parents, friends, and extended family.