School of Medicine
Showing 1-10 of 16 Results
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Zhen Xiao
Postdoctoral Scholar, Molecular Imaging Program at Stanford
Current Research and Scholarly InterestsApplying magnetic nanomaterials for bioimaging and cancer treatment
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Feng Xie
Postdoctoral Scholar, Anesthesiology, Perioperative and Pain Medicine
BioFeng Xie is currently a postdoctoral scholar at Stanford University School of Medicine, and he recently graduated with a joint Ph.D. degree from Duke University and the National University of Singapore. He previously obtained his bachelor’s degree from Tsinghua University, Beijing, China, in 2017. During his Ph.D. study, he utilized interpretable machine learning tools in acute and emergency care settings and published six first-author research papers in high-impact journals. Specifically, he developed a novel informatics framework called AutoScore, which automatically generates interpretable clinical scores from electronic health records. This open-source software package has been used by local and international researchers, downloaded about 400 times per month from the CRAN platform, and the first paper published in 2020 has garnered around 40 citations. His research interests include machine learning, clinical informatics and decision-making, predictive models, electronic health records, and risk stratification in acute care settings.
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Jian Xiong
Postdoctoral Scholar, Chemical Engineering
BioI thrive to understand the roles of lysosomes in physiological and pathological conditions. Lysosomes are both degradation compartment and metabolic controlling hub, and dysregulation of lysosomal functions are frequently implicated in a vast number of diseases including neurodegenerative diseases, however, the systematic knowledge of the molecular mechanism by which lysosomal contributes to these diseases is lacking. Ion channels are the primary mediators of neuronal activity, defects in neuronal ion channel activity are linked with many kinds of neurodegenerative diseases. Interestingly, besides typical ion channels that are involved in the neuronal activity, defects in lysosomal ion channels, such as TRPML1, CLN7 and CLC-7 are also implicated in neuropathy. My previous work as Ph.D student in University of Texas MD Anderson Cancer Center focused on regulation of lysosomal function by ion channels and metabolites. I discovered a mechanism of lysosomal Na+ channel regulate mTORC1 activation by regulating lysosomal amino acid accumulation. I also discovered role of glutamine in controlling lysosomal degradation capacity. In the meantime, I developed novel methods to isolate organelles. My ultimate research goal is to understand the key developmental pathways and how alterations in gene sequences and expression contribute to human disease, therefore, I am pursuing independent academic researcher as my career goal. Starting Feb 2022, I work with Dr. Monther Abu-Remaileh at Stanford University on role of lysosomes in neurodegenerative diseases. I use genetics, chemical biology and omics approaches to study lysosome function under various physiological and pathological conditions, especially age-associated neurodegenerative disorders, and monogenic neurodegenerative lysosome storage diseases. In Stanford, I aim to integrate ionic regulation, metabolomic regulation and functional proteomic regulation to systematically understand the biology of lysosome in physiological conditions and pathological conditions.
