School of Medicine
Showing 1-10 of 18 Results
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Aranyak Goswami
Postdoctoral Scholar, Human Gene Therapy
BioAranyak earned his Master’s in the field of Human Genetics from the University of Calcutta, India. As a part of his master's thesis at the Indian Institute of Chemical Biology, he conducted studies on the elucidation of the diversified genetic effects of the TLR-9 gene in Indian population subgroups. He continued his association with the Indian Institute of Chemical Biology and completed his Ph.D. in the field of Bioinformatics and microbial genomics under Dr. Chitra Dutta, one of the pioneers of Bioinformatics in India.
As part of his Ph.D. studies, he elucidated evolutionary adaptive strategies used by Bacillus who have adapted to a wide variety of ecological habitats, and the crucial role its members play as part of the human microbiome. He joined the Kay Lab in April 2022 after postdoctoral work at Bose Institute in India and Yale University School of Medicine in the field of computational genomics and bioinformatics on a diverse set of topics from computational human genetics to bulk and single-cell RNA sequencing. In the Kay Lab, his focus is to conduct bioinformatics and genomics analysis in the areas of gene therapy and RNA-mediated gene regulation for disease treatment. In his spare time, he enjoys creative writing, reading, and watching movies with his wife. -
Noor A. Hussein
Postdoctoral Scholar, Human Gene Therapy
BioIam a pharmacologist scientist. My experience as a researcher has taught me to seek out new perspectives for exploration and discovery. As a dedicated biological and pharmacological researcher with over 7 years of experience with models of diseases such as cancer both in vitro and in vivo. During my masters and Ph.D. studies, I mastered lots of molecular biology techniques, including cell culture, cytotoxicity assays, western blot, quantitative PCR, immunofluorescence, flow cytometry. I utilized my skills to design experiments finding solutions to common problems in the biomedical field, especially cancer experimental and molecular therapeutics.
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Wei Jiang
Instructor, Pediatrics - Human Gene Therapy
Current Research and Scholarly InterestsI have a particular interest in MHC-II antigen presentation and MHC-II-associated autoimmunity that are linked to environmental triggers. Relevant diseases include narcolepsy, celiac disease, influenza infection and COVID-19. Given multidisciplinary background, I also have developed high throughput engineering tools to advance diagnosis and/or treatment of these diseases.
Projects include:
•To study DO/DM regulated MHC-II antigen presentation in relevant to T cell-B cell immunity.
•To study MHC-II-restricted CD4+ T cells cross-reactive with self-protein and viral antigen (i.e., derived from the H1N1 influenza virus or the SARS-CoV-2 virus).
•To develop T cell receptor mimics for identification of gluten presenting cells in celiac disease.
•To develop high throughput yeast display system for MHC-II ligand identification. -
Mark A. Kay, M.D., Ph.D.
Dennis Farrey Family Professor of Pediatrics, and Professor of Genetics
Current Research and Scholarly InterestsMark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.
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Elizabeth Mellins
Professor of Pediatrics (Human Gene Therapy)
Current Research and Scholarly InterestsMolecular mechanisms and intracellular pathways of MHC class II antigen processing and presentation, with a focus on B cells; mechanisms underlying HLA allele association with disease; disease mechanisms in systemic juvenile idiopathic arthritis, including an HLA-linked complication; monocytes as drivers or suppressors of auto-inflammation in systemic juvenile idiopathic arthritis and pediatric acute neuropsychiatric syndrome.
