School of Medicine
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Adriana Verenisse Gonzalez Sandoval
Postdoctoral Research Fellow, Human Gene Therapy
Postdoctoral Asssociate, SOM Career Center
BioAdriana Gonzalez is a postdoctoral researcher, who is part of the Walter & Berry Postdoctoral Fellowship Program. Her research is related to gene therapy and chromatin organization, seeking for a better understanding of viral gene therapy mechanisms. Adriana holds a B.S. in Genomic Sciences from the National University of Mexico (UNAM), Mexico and a Ph.D. in Genetics form the University of Basel, Switzerland. She is the author of several publications related to silent chromatin organization. Adriana is eager to learn new techniques and immerse into the field of AAV gene therapy and contribute to it.
Instructor, Pediatrics - Human Gene Therapy
Current Research and Scholarly InterestsI have a particular interest in MHC-II antigen presentation and MHC-II-associated autoimmunity that are linked to environmental triggers. Relevant diseases include narcolepsy, celiac disease, influenza infection and COVID-19. Given multidisciplinary background, I also have developed high throughput engineering tools to advance diagnosis and/or treatment of these diseases.
•To study DO/DM regulated MHC-II antigen presentation in relevant to T cell-B cell immunity.
•To study MHC-II-restricted CD4+ T cells cross-reactive with self-protein and viral antigen (i.e., derived from the H1N1 influenza virus or the SARS-CoV-2 virus).
•To develop T cell receptor mimics for identification of gluten presenting cells in celiac disease.
•To develop high throughput yeast display system for MHC-II ligand identification.
Mark A. Kay, M.D., Ph.D.
Dennis Farrey Family Professor of Pediatrics, and Professor of Genetics
Current Research and Scholarly InterestsMark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.
Professor of Pediatrics (Human Gene Therapy)
Current Research and Scholarly InterestsMolecular mechanisms and intracellular pathways of antigen processing and presentation; structure/function of HLA-DR,-DM, -DO; mechanisms underlying HLA allele association with disease; disease mechanisms in systemic idiopathic juveile arthritis, recently found to be an HLA-linked disease.